1.6.5.4: monodehydroascorbate reductase (NADH)

This is an abbreviated version!
For detailed information about monodehydroascorbate reductase (NADH), go to the full flat file.

Reaction

Synonyms

12-oxophytodienoate reductase 3, AFR reductase, AFR-reductase, AFRR, ascorbate free radical reductase, ascorbate free-radical reductase, ascorbic free radical reductase, At1g63940, At3g09940, AtMDAR1, defensin, MDA, MDA reductase, MDAR, MDAR-OX, MDAR1, MDAR2, MDAR5, MDAsA reductase (NADPH), MDHA, MDHAR, MDHAR1, MDHAR2, MDHAR3, MDHAR6, metallothionein-like type 1 protein, monodehydroascorbate radical reductase, monodehydroascorbate reductase, monodehydroascorbate reductase 2, monodehydroascorbate reductase 4, More, MT-2, MT1K, NADH-semidehydroascorbate oxidoreductase, NADH:AFR oxidoreductase, NADH:ascorbate radical oxidoreductase, NADH:semidehydroascorbic acid oxidoreductase, NEC3, Nectarin III, OPR3, Os09g0567300, peroxisomal monodehydroascorbate reductase, PpMDHAR1, PpMDHAR2, PpMDHAR3, SDA reductase, semidehydroascorbate reductase, Solyc09g009390, SOR, SPD1, thioredoxin H2, Trx h2

ECTree

     1 Oxidoreductases

         1.6 Acting on NADH or NADPH

             1.6.5 With a quinone or similar compound as acceptor

                1.6.5.4 monodehydroascorbate reductase (NADH)

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Results	in table
7	Activating Compound
165	AA Sequence
2	Application
1	CAS Registry Number
24	Cloned(Commentary)
81	Cofactor
5	Crystallization (Commentary)
1456	Disease/ Diagnostics
12	Expression
26	General Information
3	General Stability
57	Inhibitors
4	kcat/KM [mM/s]
1	Ki Value [mM]
47	KM Value [mM]
62	Localization
1	Metals/Ions
22	Molecular Weight [Da]
34	Natural Substrates/ Products (Substrates)
93	Organism
3	Pathway
10	pH Optimum
4	pH Range
1	pH Stability
11	pI Value
15	Protein Variants
13	Purification (Commentary)
6	Reaction
3	Reaction Type
88	Reference
1	Renatured (Commentary)
93	Source Tissue
16	Specific Activity [micromol/min/mg]
4	Storage Stability
130	Substrates and Products (Substrate)
19	Subunits
94	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
3	Temperature Stability [°C]
9	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.6.5.4 - monodehydroascorbate reductase (NADH)

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

CO2 + H2O

HCO3- + H+

Nicotiana langsdorffii x Nicotiana sanderae

Q84UV8

bifunctional enzyme showing monodehydroascorbate reductase and carbonic anhydrase, EC 4.2.1.1, activities

657024

-

-

?

NADH + H+ + 2 monodehydroascorbate

NAD+ + 2 ascorbate

3 entries

NADH + monodehydroascorbate

NAD+ + ascorbate

26 entries

NADPH + H+ + 2 monodehydroascorbate

NADP+ + 2 ascorbate

2 entries

additional information

?

-

Nicotiana langsdorffii x Nicotiana sanderae

Q84UV8

reaction scheme, the enzyme is involved in nectary production in floral organs, multiple molecular mechanism responsible for expression in the nectary gland

657024

-

-

?

NADH + H+ + 2 monodehydroascorbate

NAD+ + 2 ascorbate

Solanum lycopersicum

-

-

726105, 726130

-

-

?

NADH + H+ + 2 monodehydroascorbate

NAD+ + 2 ascorbate

Solanum lycopersicum West Virginia 106

-

-

726130

-

-

?

NADH + H+ + 2 monodehydroascorbate

NAD+ + 2 ascorbate

Solanum lycopersicum Zhongshu 4

-

-

726105

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Allium cepa

-

the enzyme is involved in maintaining the ascorbic acid system in the reduced state

392744

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Brassica oleracea

-

the enzyme is involved in maintaining the ascorbic acid system in the reduced state

392744

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Brassica rapa subsp. pekinensis

Q93X74

enzyme is involved in the ascorbate-glutathione cycle together with EC 1.8.5.1, and EC 1.6.4.2

654881

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Cucumis sativus

-

-

392744

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Cuscuta reflexa

-

key enzyme for maintaining the ascorbic acid system in the reduced state

392730

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Gigartina sp.

-

the enzyme is involved in maintaining the ascorbic acid system in the reduced state

392744

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Glycine max

-

enzyme of the ascorbate-glutathione cycle

392727

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Gracilaria sp.

-

the enzyme is involved in maintaining the ascorbic acid system in the reduced state

392744

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Helianthus tuberosus

-

the enzyme is involved in maintaining the ascorbic acid system in the reduced state

392744

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Homo sapiens

-

enzyme may constitute part of cellular mechanisms which protect against and repair oxidant injury to biomolecules

392737

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Hypnea sp.

-

the enzyme is involved in maintaining the ascorbic acid system in the reduced state

392744

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Mus musculus

-

the enzyme is involved in maintaining the ascorbic acid system in the reduced state

392744

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Nicotiana langsdorffii x Nicotiana sanderae

Q84UV8

enzyme is responsible for maintaining ascorbate concentrations in nectar

657024

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Oryctolagus cuniculus

-

-

655510

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Pisum sativum

-

key enzyme in maintaining reduced pools of ascorbate

392750

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Pisum sativum

-

the enzyme is involved in maintaining the ascorbic acid system in the reduced state

392744

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Pterocladia sp.

-

the enzyme is involved in maintaining the ascorbic acid system in the reduced state

392744

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Rattus norvegicus

-

the enzyme is involved in part of the transplasmamembrane redox system

392753

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Rattus norvegicus

-

the enzyme supports cholesterol side chain cleavage, the enzyme functions to provide cytoplasmic reducing equivalents to intramitochondrial cytochrome P-450SCC

392745

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Rattus norvegicus

-

the only physiologically important system for the regeneration of ascorbate

392742

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Rattus norvegicus

-

involvement of semidehydroascorbate reductase in the oxidation of NADH by lipid peroxide in mitochondria and microsomes

392741

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Ricinus communis

-

the enzyme sustains glyoxysomal NAD+ during beta-oxidation, the glyoxylate cycle and gluconeogenesis in the endosperm during germination

392729

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Solanum tuberosum

-

the enzyme is involved in maintaining the ascorbic acid system in the reduced state

392744

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Solanum tuberosum

-

enzyme participates in the regeneration of ascorbate for scavenging toxic oxygen species in potato tuber mitochondria

392747

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Solanum tuberosum

-

the enzyme is an effective scavenger of the monodehydroascorbate radical

392747

-

-

?

NADH + monodehydroascorbate

NAD+ + ascorbate

Vicia faba

-

the enzyme is involved in maintaining the ascorbic acid system in the reduced state

392744

-

-

?

NADPH + H+ + 2 monodehydroascorbate

NADP+ + 2 ascorbate

Solanum lycopersicum

-

-

726105

-

-

?

NADPH + H+ + 2 monodehydroascorbate

NADP+ + 2 ascorbate

Solanum lycopersicum Zhongshu 4

-

-

726105

-

-

?