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EC 1.6.5.9: NADH:quinone reductase (non-electrogenic)

This is an abbreviated version!
For detailed information about NADH:quinone reductase (non-electrogenic), go to the full flat file.

Wordmap for 1.6.5.9

Word Map on EC 1.6.5.9 Wordmap for 1.6.5.9

Reaction

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NADH
+
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H+
+
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a quinone
=
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NAD+
+
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a quinol

Synonyms

alternative external NADH dehydrogenase, alternative NADH dehydrogenase, alternative NADH-quinone oxidoreductase, alternative NADH:quinone reductase, alternative NADH:ubiquinone oxidoreductase, alternative rotenone-insensitive NADH:Q oxidoreductase, CathTA2_0279, Cgl1465, EC 1.6.5.11, EC 1.6.99.5, external alternative NADH dehydrogenase, external alternative NADH: ubiquinone oxidoreductase, external NADH:ubiquinone oxidoreductase, external rotenone-insensitive NADH dehydrogenase, internal alternative NADH dehydrogenase, internal alternative NADH: ubiquinone oxidoreductase, internal alternative NADH:ubiquinone oxidoreductase, Internal NADH dehydrogenase, internal rotenone-insensitive NADH dehydrogenase, NADH dehydrogenase, NADH dehydrogenase-2, NADH-ubiquinone oxidoreductase, NADH: ubiquinone oxidoreductase, NADH: ubiquinone-2 oxidoreductase, NADH:Q6 oxidoreductase, NADH:ubiquinone reductase (non-electrogenic), NADHQ2, NDA, NDB, NdeA, NdeA-B, NDH, NDH-2, NDH-II, NDH2, NDH2e, NDH2i, Ndi1, NdiA, NDX, non-proton pumping type II NADH dehydrogenase, non-proton-pumping NADH dehydrogenase, rotenone-insensitive NADH dehydrogenase, rotenone-insensitive NADH-ubiquinone oxidoreductase

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.5 With a quinone or similar compound as acceptor
                EC 1.6.5.91.6.5.9 NADH:quinone reductase (non-electrogenic)

Inhibitors

Inhibitors on EC 1.6.5.9 - NADH:quinone reductase (non-electrogenic)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-hydroxy-2-dodecyl-4(1H)quinolone
-
28% residual activity at 0.01 mM
2,6-dichlorophenolindophenol
-
substrate inhibition
aculeacin A
-
63% residual activity at 0.005 mg/ml
AMP
-
dead end reversible inhibitor, competitive inhibitor of NADH and uncompetitive inhibitor of 2,6-dichlorophenolindophenol
aurachin analogue AC0-10
specific inhibitor
aurachin C 1-10
-
12% residual activity at 0.01 mM, noncompetitive inhibitor
flavone
funiculosin
-
68% residual activity at 0.005 mg/ml
Gramicidin S
-
31% residual activity at 0.005 mg/ml
mangostin
20 microM, 19% residual activity for detergent-solubilized enzyme
morin
20 microM, 32% residual activity for detergent-solubilized enzyme, 18.7% residual activity for lipid-reconstituted enzyme
NADH
-
substrate inhibition
nordihydroguaiaretic acid
20 microM, 33% residual activity for detergent-solubilized enzyme, 18.7% residual activity for lipid-reconstituted enzyme
piceatannol
20 microM, 35% residual activity for detergent-solubilized enzyme
polymixin B
-
51% residual activity at 0.005 mg/ml
reduced 2,6-dichlorophenolindophenol
-
product inhibition
rotenone
-
three NADH dehydrogenases, two external rotenone-insensitive NADH:ubiquinone oxidoreductases (NDE1 and NDE2), and one internal rotenone-insensitive NADH:ubiquinone reductase (NDI1)
scopafungin
-
33% residual activity at 0.005 mg/ml, noncompetitive inhibitor
staurosporine
-
70% residual activity at 0.005 mg/ml
tyrphostin AG 537
20 microM, 22% residual activity for detergent-solubilized enzyme, 57% residual activity for lipid-reconstituted enzyme
tyrphostin AG 808
20 microM, 7% residual activity for detergent-solubilized enzyme
additional information
-