1.7.1.13: preQ1 synthase

This is an abbreviated version!
For detailed information about preQ1 synthase, go to the full flat file.

Word Map on EC 1.7.1.13

1.7.1.13

nucleoside

queuosine

7-aminomethyl-7-deazaguanine

adduct

gtp

reductases

imine

Reaction

+ 2 NADP⁺ =

+ 2 NADPH + 2 H+

Synonyms

7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase, 7-cyano-7-deazaguanine reductase, NADPH-dependent 7-cyano-7-deazaguanine reductase, nitrile reductase, NRed, preQ0 reductase, preQ0oxidoreductase, QueF, queuine synthase, YkvM

ECTree

1 Oxidoreductases

1.7 Acting on other nitrogenous compounds as donors

1.7.1 With NAD⁺ or NADP⁺ as acceptor

1.7.1.13 preQ1 synthase

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Inhibitors on EC 1.7.1.13 - preQ1 synthase

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7-formyl-7-deazaguanine

Escherichia coli

carbonyl analogue of the imine intermediate, recognized by QueF as weak ligand for binding but not as substrate for reduction or oxidation

742900

EDTA

Pectobacterium carotovorum subsp. carotovorum

C6DAH4

0.1 mM, 89% residual activity

743107

peroxide

Bacillus subtilis

O31678

peroxide-induced inactivation of the wild-type enzyme is reversible with thioredoxin

742061