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1.7.1.13: preQ1 synthase

This is an abbreviated version!
For detailed information about preQ1 synthase, go to the full flat file.

Word Map on EC 1.7.1.13

Reaction

7-aminomethyl-7-carbaguanine
+ 2 NADP+ =
7-cyano-7-carbaguanine
+ 2 NADPH + 2 H+

Synonyms

7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase, 7-cyano-7-deazaguanine reductase, NADPH-dependent 7-cyano-7-deazaguanine reductase, nitrile reductase, NRed, preQ0 reductase, preQ0oxidoreductase, QueF, queuine synthase, YkvM

ECTree

     1 Oxidoreductases
         1.7 Acting on other nitrogenous compounds as donors
             1.7.1 With NAD+ or NADP+ as acceptor
                1.7.1.13 preQ1 synthase

Reference

Reference on EC 1.7.1.13 - preQ1 synthase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Swairjo, M.A.; Reddy, R.R.; Lee, B.; Van Lanen, S.G.; Brown, S.; de Crecy-Lagard, V.; Iwata-Reuyl, D.; Schimmel, P.
Crystallization and preliminary x-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme
Acta Crystallogr. Sect. F
F61
945-948
2005
Bacillus subtilis (O31678), Bacillus subtilis
Manually annotated by BRENDA team
Kuchino, Y.; Kasai, H.; Nihei, K.; Nishimura, S.
Biosynthesis of the modified nucleoside Q in transfer RNA
Nucleic Acids Res.
3
393-398
1976
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Okada, N.; Noguchi, S.; Nishimura, S.; Ohgi, T.; Goto, T.; Crain, P.F.; McCloskey, J.A.
Structure determination of a nucleoside Q precursor isolated from E. coli tRNA: 7-(aminomethyl)-7-deazaguanosine
Nucleic Acids Res.
5
2289-2296
1978
Escherichia coli
Manually annotated by BRENDA team
Noguchi, S.; Yamaizumi, Z.; Ohgi, T.; Goto, T.; Nishimura, Y.; Hirota, Y.; Nishimura, S.
Isolation of Q nucleoside precursor present in tRNA of an E. coli mutant and its characterization as 7-(cyano)-7-deazaguanosine
Nucleic Acids Res.
5
4215-4223
1978
Escherichia coli
Manually annotated by BRENDA team
van Lanen, S.G.; Reader, J.S.; Swairjo, M.A.; de Crecy-Lagard, V.; Lee, B.; Iwata-Reuyl, D.
From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold
Proc. Natl. Acad. Sci. USA
102
4264-4269
2005
Bacillus subtilis, Escherichia coli
Manually annotated by BRENDA team
Kim, Y.; Zhou, M.; Moy, S.; Morales, J.; Cunningham, M.A.; Joachimiak, A.
High-resolution structure of the nitrile reductase QueF combined with molecular simulations provide insight into enzyme mechanism
J. Mol. Biol.
404
127-137
2010
Vibrio cholerae (Q9KTK0), Vibrio cholerae, Vibrio cholerae ATCC 39315 (Q9KTK0)
Manually annotated by BRENDA team
Wilding, B.; Winkler, M.; Petschacher, B.; Kratzer, R.; Egger, S.; Steinkellner, G.; Lyskowski, A.; Nidetzky, B.; Gruber, K.; Klempier, N.
Targeting the substrate binding site of E. coli nitrile reductase QueF by modeling, substrate and enzyme engineering
Chemistry
19
7007-7012
2013
Escherichia coli (Q46920), Escherichia coli
Manually annotated by BRENDA team
Moeller, K.; Nguyen, G.S.; Hollmann, F.; Hanefeld, U.
Expression and characterization of the nitrile reductase queF from E. coli
Enzyme Microb. Technol.
52
129-133
2013
Escherichia coli (Q46920)
Manually annotated by BRENDA team
Ribeiro, A.; Yang, L.; Ramos, M.; Fernandes, P.; Liang, Z.; Hirao, H.
Insight into enzymatic nitrile reduction QM/MM study of the catalytic mechanism of QueF nitrile reductase
ACS Catal.
5
3740-3751
2015
Vibrio cholerae O1 (Q9KTK0), Vibrio cholerae O1 ATCC 39315 (Q9KTK0)
-
Manually annotated by BRENDA team
Mohammad, A.; Bon Ramos, A.; Lee, B.W.; Cohen, S.W.; Kiani, M.K.; Iwata-Reuyl, D.; Stec, B.; Swairjo, M.A.
Protection of the queuosine biosynthesis enzyme QueF from irreversible oxidation by a conserved intramolecular disulfide
Biomolecules
7
E30
2017
Bacillus subtilis (O31678), Bacillus subtilis 168 (O31678)
Manually annotated by BRENDA team
Gjonaj, L.; Pinkse, M.; Fernandez-Fueyo, E.; Hollmann, F.; Hanefeld, U.
Substrate and cofactor binding to nitrile reductase A mass spectrometry based study
Catal. Sci. Technol.
6
7391-7397
2016
Escherichia coli (Q46920)
-
Manually annotated by BRENDA team
Jung, J.; Czabany, T.; Wilding, B.; Klempier, N.; Nidetzky, B.
Kinetic analysis and probing with substrate analogues of the reaction pathway of the nitrile reductase QueF from Escherichia coli
J. Biol. Chem.
291
25411-25426
2016
Escherichia coli
Manually annotated by BRENDA team
Li, M.; Zhou, Z.; Zhang, Z.; Yu, H.; Xu, J.
Biochemical properties of a new nitrile reductase cloned from Pectobacterium carotovorum
J. Mol. Catal. B
131
47-54
2016
Pectobacterium carotovorum subsp. carotovorum (C6DAH4), Pectobacterium carotovorum subsp. carotovorum PCC21 (C6DAH4)
-
Manually annotated by BRENDA team
Jung, J.; Braun, J.; Czabany, T.; Nidetzky, B.
Interplay of nucleophilic catalysis with proton transfer in the nitrile reductase QueF from Escherichia coli
Catal. Sci. Technol.
9
842-853
2019
Escherichia coli (Q46920)
-
Manually annotated by BRENDA team
Jung, J.; Nidetzky, B.
Evidence of a sequestered imine intermediate during reduction of nitrile to amine by the nitrile reductase QueF from Escherichia coli
J. Biol. Chem.
293
3720-3733
2018
Escherichia coli (Q46920)
Manually annotated by BRENDA team