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1.7.1.17: FMN-dependent NADH-azoreductase

This is an abbreviated version!
For detailed information about FMN-dependent NADH-azoreductase, go to the full flat file.

Reaction

anthranilate
+
N,N-dimethyl-1,4-phenylenediamine
+ 2 NAD+ =
2-(4-dimethylaminophenyl)diazenylbenzoate
+ 2 NADH + 2 H+

Synonyms

acpD, AZO, azo-dye reductase, AzoA, AzoR, AzoR1, azoreductase, AzoRo, AzrA, AzrG, flavin-containing oxygen-insensitive azoreductase, FMN dependent azoreductase, FMN-dependent methyl red reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azo reductase, FMN-dependent NADH-azoreductase, FMN-dependent-NADH azoreductase, indigo reductase, NADH-azoreductase

ECTree

     1 Oxidoreductases
         1.7 Acting on other nitrogenous compounds as donors
             1.7.1 With NAD+ or NADP+ as acceptor
                1.7.1.17 FMN-dependent NADH-azoreductase

Inhibitors

Inhibitors on EC 1.7.1.17 - FMN-dependent NADH-azoreductase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ca2+
10% inhibition at 0.05 mM
dicoumarol
Fe2+
13% inhibition at 0.05 mM
Fe3+
14% inhibition at 0.05 mM
guanidine hydrochloride
55% activity of azoreductase decreases at up to 2 M guanidine hydrochloride concentration while complete loss of activity is found at 3.5 M concentration
Mg2+
8% inhibition at 0.05 mM
Urea
50% activity is lost up to 2 M urea concentration and complete loss of activity is observed at 4 M urea
Zn2+
16% inhibition at 0.05 mM
additional information
the enzyme is oxygen-insensitive
-