1.7.1.9: nitroquinoline-N-oxide reductase

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For detailed information about nitroquinoline-N-oxide reductase, go to the full flat file.

Reaction

Synonyms

4-nitroquinoline 1-oxide reductase, 4NQO reductase, EC 1.6.6.10, NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase

ECTree

     1 Oxidoreductases

         1.7 Acting on other nitrogenous compounds as donors

             1.7.1 With NAD⁺ or NADP⁺ as acceptor

                1.7.1.9 nitroquinoline-N-oxide reductase

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CAS Registry Number

3

Inhibitors

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KM Value [mM]

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Localization

1

Molecular Weight [Da]

10

Organism

1

Purification (Commentary)

2

Reaction

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Reaction Type

10

Reference

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Specific Activity [micromol/min/mg]

10

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4

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Reaction

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Reaction on EC 1.7.1.9 - nitroquinoline-N-oxide reductase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+

2 entries

4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+

4-(hydroxyamino)quinoline N-oxide may be the active intermediate essential in the carcinogenic process of 4-nitroquinoline N-oxide

Canis lupus familiaris

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392945

4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+

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