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1.7.1.B3: aromatic nitroreductase [NADPH]

This is an abbreviated version!
For detailed information about aromatic nitroreductase [NADPH], go to the full flat file.

Wordmap for 1.7.1.B3

Word Map on EC 1.7.1.B3 Wordmap for 1.7.1.B3

Reaction

Show molfile
an aromatic amine
+ 3 NADP+ + 2 H2O =
Show molfile
an aromatic nitrate
+ 3 NADPH + 3 H+

Synonyms

ipa-43d, More, NADPH-FMN reductase, NADPH-nitrofurazone reductase, NfrA1, NfsA, nitro/flavin reductase, nitrofurazone reductase, nitroreductase A, non-luminescent-bacterial NfsA/Frp-type enzyme, NR-A, ORF 17150, oxygen-insensitive NAD(P)H:nitroreductases, oxygen-insensitive nitroreductase (NADPH)

ECTree

     1 Oxidoreductases
         1.7 Acting on other nitrogenous compounds as donors
             1.7.1 With NAD+ or NADP+ as acceptor
                EC 1.7.1.B31.7.1.B3 aromatic nitroreductase [NADPH]

Inhibitors

Inhibitors on EC 1.7.1.B3 - aromatic nitroreductase [NADPH]

for references in articles please use BRENDA:EC1.7.1.B3

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ascorbate
-
-
dicoumarol
-
inhibits Escherichia coli enzyme NfsB far more strongly than enzyme NfsA, by acting as a competitive inhibitor towards NADPH, uncompetitive towards substrate tetryl
NADP+
-
inhibition of NfsA-catalyzed tetryl reduction by NADP+
additional information
the enzyme is O2-insensitive
-