1.7.1.B3: aromatic nitroreductase [NADPH]
This is an abbreviated version!
For detailed information about aromatic nitroreductase [NADPH], go to the full flat file.
Word Map on EC 1.7.1.B3
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1.7.1.B3
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hypoplasia
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dermal
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x-linked
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goltz
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ectodermal
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malformation
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ocular
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porcupine
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mesoderm
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blaschko
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skew
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x-chromosome
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postzygotic
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teeth
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goltz-gorlin
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multisystemic
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herniation
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diaphragmatic
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x-inactivation
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angioma
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papillomas
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hernia
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wingless
-
cutis
-
nail
-
o-acyltransferase
-
aplasia
-
patchy
-
environmental protection
-
medicine
- 1.7.1.B3
-
hypoplasia
-
dermal
-
x-linked
-
goltz
-
ectodermal
-
malformation
-
ocular
-
porcupine
-
mesoderm
-
blaschko
-
skew
-
x-chromosome
-
postzygotic
-
teeth
-
goltz-gorlin
-
multisystemic
-
herniation
-
diaphragmatic
-
x-inactivation
-
angioma
-
papillomas
-
hernia
-
wingless
-
cutis
-
nail
-
o-acyltransferase
-
aplasia
-
patchy
- environmental protection
- medicine
Reaction
+ 3 NADP+ + 2 H2O = + 3 NADPH + 3 H+
Synonyms
ipa-43d, More, NADPH-FMN reductase, NADPH-nitrofurazone reductase, NfrA1, NfsA, nitro/flavin reductase, nitrofurazone reductase, nitroreductase A, non-luminescent-bacterial NfsA/Frp-type enzyme, NR-A, ORF 17150, oxygen-insensitive NAD(P)H:nitroreductases, oxygen-insensitive nitroreductase (NADPH)
ECTree
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KM Value
KM Value on EC 1.7.1.B3 - aromatic nitroreductase [NADPH]
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0.3257
2-amino-4,6-dinitrotoluene
pH 7.0, 37°C, recombinant His6-tagged enzyme
0.6427
4-amino-2,6-dinitrotoluene
pH 7.0, 37°C, recombinant His6-tagged enzyme
0.029
2,4,6-trinitrotoluene
recombinant wild-type enzyme, pH 7.0, 22°C
0.029
2,4,6-trinitrotoluene
pH 7.0, 37°C, recombinant His6-tagged enzyme
0.322
5-(aziridin-1-yl)-2,4-dinitrobenzamide
recombinant mutant F46Y, pH 7.0, 22°C
0.327
5-(aziridin-1-yl)-2,4-dinitrobenzamide
recombinant wild-type enzyme, pH 7.0, 22°C
0.332
5-(aziridin-1-yl)-2,4-dinitrobenzamide
recombinant mutant F46Y, pH 7.0, 22°C
0.487
5-(aziridin-1-yl)-2,4-dinitrobenzamide
recombinant mutant F46Y, pH 7.0, 22°C
additional information
Michaelis-Menten steady-state kinetics
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additional information
additional information
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enzyme kinetic analysis, overview
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additional information
additional information
Michaelis-Menten steady-state kinetics of recombinant His6-tagged enzyme
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additional information
additional information
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Michaelis-Menten steady-state kinetics. For NfsA the oxidative half-reaction (i.e., the reoxidation of FMNH by the oxidant substrate) is a rate-limiting step, because the values of kcat at infinite concentrations of tetryl or 2,4,6-trinitrotoluene are substantially lower than the lowest rate of the reductive half reaction (the reduction of FMN by NADPH) measured in the preliminary rapid reaction experiments. Stopped-flow and single-turnover measurements
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