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1.7.2.3: trimethylamine-N-oxide reductase

This is an abbreviated version!
For detailed information about trimethylamine-N-oxide reductase, go to the full flat file.

Word Map on EC 1.7.2.3

Reaction

trimethylamine
+ 2 (ferricytochrome c)-subunit +
H2O
=
Trimethylamine N-oxide
+ 2 (ferrocytochrome c)-subunit + 2 H+

Synonyms

EC 1.6.6.9, More, reductase, trimethylamine N-oxide, TMAO reductase, TOR, TorA, TorD, torECA gene product, TorECAD, TorZ, trimethylamine N-oxide reductase, trimethylamine oxide reductase

ECTree

     1 Oxidoreductases
         1.7 Acting on other nitrogenous compounds as donors
             1.7.2 With a cytochrome as acceptor
                1.7.2.3 trimethylamine-N-oxide reductase

Inhibitors

Inhibitors on EC 1.7.2.3 - trimethylamine-N-oxide reductase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
2,2-dipyridyl
-
slight
5,5'-dithiobis(2-nitrobenzoate)
-
-
DTT
-
inhibits cytochrome c formation
EGTA
-
38% inhibition at 10 mM
FAD
-
inhibition, when added to the standard assay mixture containing benzyl viologen as electron acceptor
FMN
-
inhibition, when added to the standard assay mixture containing benzyl viologen as electron acceptor
iodoacetate
-
partial
N-ethylmaleimide
-
both inducible and constitutive enzyme are affected equally at 5 mM
Na2MoO4
-
-
Na2WO4
-
-
p-chloromercuribenzoate
Sodium chlorate
-
partial
Urea
-
50% inhibition at 6 mM
additional information
-
not influenced by iodoacetamide
-