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1.8.1.12: trypanothione-disulfide reductase

This is an abbreviated version!
For detailed information about trypanothione-disulfide reductase, go to the full flat file.

Word Map on EC 1.8.1.12

Reaction

trypanothione
+
NADP+
=
trypanothione disulfide
 +
NADPH
 +
H+

Synonyms

EC 1.6.4.8, LbTryR, LdTryR, Li-TryR, LiTR, N(1),N(8)-bis(glutathionyl)spermidine reductase, NADPH2:trypanothione oxidoreductase, TbTR, TCDM_11669, TcTR, TPR, TR, trypanothione disulfide reductase, trypanothione reductase, trypanothione-disulfide reductase, TryR

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.1 With NAD+ or NADP+ as acceptor
                1.8.1.12 trypanothione-disulfide reductase

IC50 Value

IC50 Value on EC 1.8.1.12 - trypanothione-disulfide reductase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0085
(1,3,5-triaza-7-phosphaadamantane)Au(saccharine)
Leishmania infantum
-
at pH 7.5 and 25°C
-
0.0065
(1E,2E)-3-(5-nitrofuran-2-yl)prop-2-enal N-hexylsemicarbazone
Trypanosoma cruzi
-
-
0.0829
(2-chloroethoxy)diphenylmethane
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0021
(2E)-3-(5-nitrofuran-2-yl)-N-tricyclo[3.3.1.13,7]dec-1-ylprop-2-enamide
Trypanosoma cruzi
-
-
0.0023
(2E)-N-hexyl-3-(5-nitrofuran-2-yl)prop-2-enamide
Trypanosoma cruzi
-
-
0.023
(2Z)-2-[(2E)-2-(3H-indol-3-ylidene)ethylidene]-1-methyl-1,2-dihydroquinoline
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.1
(3'R,4'R)-3'-carbamoyl-1'-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-1,4'-bipiperidinium
0.013
(4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidinyl-1'-yl)(phenyl)-methanone
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.0013
1,1'-[ethane-1,2-diylbis(oxyethane-2,1-diyl)]bis(3-benzyl-1,3-dihydro-2H-benzimidazol-2-imine)
Trypanosoma brucei rhodesiense
-
-
0.1
1,1'-[methanediylbis(oxyethane-2,1-diyl)]bis(3-methyl-1,3-dihydro-2H-benzimidazol-2-imine)
Trypanosoma brucei
-
IC50: 0.1 mM
0.004
1,1'-[methanediylbis(oxyethane-2,1-diyl)]bis(3-phenyl-1,3-dihydro-2H-benzimidazol-2-imine)
Trypanosoma brucei
-
IC50: 0.004 mM
0.0086
1,6-dimethyl-3-(4-methylphenyl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0044
1-((1-benzo[b]furan-2-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.1
1-((1-benzo[b]thiazol-2-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.01
1-((1-benzo[b]thiophen-2-yl)cyclohexyl)-4-methylpiperazine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.005
1-((1-benzo[b]thiophen-2-yl)cyclohexyl)diethylamine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.00091
1-((1-benzo[b]thiophen-2-yl)cyclohexyl)pyrrolidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.011
1-((1-benzo[b]thiophen-2-yl)cyclopentyl)piperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.06
1-((1-benzo[b]thiophen-3-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.1
1-((1-biphenyl-4-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.1
1-((1-naphthalen-1-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.028
1-((1-naphthalen-2-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.1
1-((1-thiophen-2-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.115
1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine
Trypanosoma cruzi
at 25°C, pH not specified in the publication
0.0487
1-((2-benzhydryloxy)ethyl)piperazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.015
1-((2-benzo[b]thiophen-2-yl)propan-2-yl)piperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.016
1-(1-(3-bromo-benzo[b]thiophen-2-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.1
1-(1-(5-bromo-benzo[b]thiophen-2-yl)cyclohexyl)piperidine
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.0011 - 0.05212
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
0.00233
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-4-yl)methyl)piperazine
Trypanosoma cruzi
at 25°C, pH not specified in the publication
0.00369
1-(1-benzo[b]thiophen-2-yl-cyclohexyl)-piperidine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0033
1-(1-benzo[b]thiophen-2-yl-cyclohexyl)piperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.002
1-(1-benzylpiperidin-4-yl)-3-phenylthiourea
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.1
1-(1-benzylpiperidin-4-yl)-3-pyridin-3-ylthiourea
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.1
1-(1-methylpiperidin-3-yl)-3-(2-phenoxyethyl)-1,3-dihydro-2H-benzimidazol-2-imine
Trypanosoma brucei
-
IC50: 0.1 mM
0.057
1-(1-phenylcyclohexyl)piperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.1
1-(1-phenylpiperidin-4-yl)-3-propylthiourea
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.005
1-(2,4-dichlorophenoxy)-3-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]propan-2-ol
Trypanosoma brucei
-
IC50: 0.005 mM
0.00012 - 0.00633
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
0.00013 - 0.0024
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
0.0109
1-(2-(benzhydryloxy)ethyl)-4-(3-phenylpropyl)piperazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.1
1-(2-oxo-2-[[2-(phenylsulfanyl)phenyl]amino]ethyl)-4-phenylpiperazin-1-ium
0.004
1-(2-phenoxyethyl)-3-(2-piperidin-1-ylethyl)-1,3-dihydro-2H-benzimidazol-2-imine
Trypanosoma brucei
-
IC50: 0.004 mM
0.009
1-(2-phenoxyethyl)-3-[2-(piperidin-1-yl)ethyl]-1,3-dihydro-2H-benzimidazol-2-imine
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.00255 - 0.0695
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
0.00236 - 0.0512
1-(3,4-dichlorobenzyl)-4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methylpiperazin-1-ium
0.0002 - 0.004
1-(3,4-dichlorophenyl)-2-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
0.009
1-(3,4-dichlorophenyl)-2-[3-[2-(diethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
Trypanosoma brucei
-
IC50: 0.009 mM
0.01
1-(3,4-dichlorophenyl)-2-[3-[2-(diethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]ethanone
Trypanosoma brucei
-
IC50: 0.01 mM
0.0006 - 0.01
1-(3,4-dichlorophenyl)-2-[3-[2-(dimethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]ethanol
0.107
1-(3,4-dichlorophenyl)-3-[(4-ethylphenyl)amino]propan-1-one
Trypanosoma brucei
-
-
0.1
1-(3-bromobenzyl)-5,7-dimethyl-1,3-diazoniatricyclo[3.3.1.13,7]decane
0.0017
1-(3-nitrophenyl)-3-(phenylamino)propan-1-one
Trypanosoma brucei
-
-
0.007
1-(3-phenoxypropyl)-3-(2-piperidin-1-ylethyl)-1,3-dihydro-2H-benzimidazol-2-imine
Trypanosoma brucei
-
IC50: 0.007 mM
0.0345
1-(3-phenylpropyl)piperazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0026
1-(4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidinyl-1'-yl)-2-(dimethyl-amino)ethanone
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.012
1-(4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidinyl-1'-yl)-2-phenyl-ethanone
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.0066
1-(4'-benzo[b]thiophen-2-yl)-1,4'-(bipiperidine-1'-yl)ethanone
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.1
1-(4,6,8-trimethylquinazolin-2-yl)guanidine
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.0399
1-(4-(N-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-4-(dimethylamino)-2-(2-(naphthalen-2-yl)ethyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamido)butyl)guanidinium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.1
1-(4-bromophenyl)-2-(3-butyl-2-imino-2,3-dihydro-1H-benzimidazol-1-yl)ethanol
Trypanosoma brucei
-
IC50: 0.1 mM, 42% inhibition at 0.025 mM
0.148
1-(4-chlorophenyl)-3-morpholin-4-ylpropan-1-one
Trypanosoma brucei
-
-
0.1
1-(4-ethoxyphenyl)-2-(2-imino-3-prop-2-en-1-yl-2,3-dihydro-1H-benzimidazol-1-yl)ethanol
Trypanosoma brucei
-
IC50: 0.1 mM, 6% inhibition at 0.025 mM
0.1
1-(4-methylphenyl)-5-oxo-N-[2-(phenylsulfanyl)phenyl]pyrrolidine-3-carboxamide
0.1
1-(4-methylquinazolin-2-yl)guanidine
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.008
1-(5-phenoxypentyl)-3-(2-piperidin-1-ylethyl)-1,3-dihydro-2H-benzimidazol-2-imine
Trypanosoma brucei
-
IC50: 0.008 mM
0.0291 - 0.036
1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-ethylpiperazinediium
0.1
1-(methylsulfanyl)-4-[3-(methylsulfanyl)-1,2,4-triazin-5-yl]-5,6,7,8-tetrahydroisoquinoline
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.00323 - 0.194
1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
0.0452 - 0.1
1-benzyl-4-[[(1E)-(1-cyclohexyl-2,4,6-trioxohexahydropyrimidin-5-yl)methylidene]amino]-1-methylpiperidinium
0.025
1-biphenyl-4-yl-2-[3-[2-(diethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]ethanone
Trypanosoma brucei
-
IC50: 0.025 mM
0.1
1-ethyl-6-methyl-3-(pyridin-3-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0128
1-ethyl-6-methyl-3-(thiophen-2-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0113
1-ethyl-6-methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0026
1-ethyl-6-methyl-3-[(Z)-2-phenylethenyl]pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0152
1-ethyl-6-methyl-3-[4-(trifluoromethyl)phenyl]pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.036
1-methyl-(2-(1-piperidin-1-yl)cyclohexyl)-1H-indole
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.033
1-phenyl-3-(1-phenylpiperidin-4-yl)thiourea
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.1
1-phenyl-3-[1-(pyridin-3-yl)piperidin-4-yl]urea
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.1
1-propylbenzene
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.00039 - 0.025
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
0.00023 - 0.00424
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
0.00194
1-[2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)ethyl]-4-(3-phenyl-propyl)piperazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0269
1-[2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)ethyl]-4-(E)-(3-phenyl-allyl)piperazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0515
1-[2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)ethyl]-piperazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0787 - 0.1
1-[2-(2-chloro-10H-phenothiazin-10-yl)-2-oxoethyl]azepanium
0.0032 - 0.0065
1-[2-(4-methylpiperazin-1-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
-
0.0025
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethyl-aminomethyl)-ferrocenylmethyl]-3-p-chloro-phenyl-urea
Trypanosoma cruzi
-
-
0.002
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-3-[2,6-bis-(trifluoromethyl)-phenyl]-urea
Trypanosoma cruzi
-
-
0.0023
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]-3-p-methoxyphenyl-urea
Trypanosoma cruzi
-
-
0.0105
1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]-3-[2,4-bis-(trifluoromethyl)-phenyl]-urea
Trypanosoma cruzi
-
-
0.0021 - 0.0038
1-[2-(piperazin-1-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
-
0.0029
1-[2-(piperidin-4-yl)ethyl]-5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]-1,3-thiazol-2-yl]-1H-indole
Trypanosoma cruzi
-
pH and temperature not specified in the publication
-
0.1
1-[2-imino-3-(2-morpholin-4-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3-phenoxypropan-2-ol
Trypanosoma brucei
-
IC50: 0.1 mM
0.1
1-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3,3-dimethylbutan-2-ol
Trypanosoma brucei
-
IC50: 0.1 mM, 66% inhibition at 0.025 mM
0.016
1-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3-(4-methoxyphenoxy)propan-2-ol
Trypanosoma brucei
-
IC50: 0.016 mM
0.005
1-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3-phenoxypropan-2-ol
Trypanosoma brucei
-
IC50: 0.005 mM
0.1
1-[2-imino-3-(morpholin-4-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3-(4-methylphenoxy)propan-2-ol
Trypanosoma brucei
-
IC50: 0.1 mM
0.009
1-[2-imino-3-(piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-3-(4-methylphenoxy)propan-2-ol
Trypanosoma brucei
-
IC50: 0.009 mM
0.00009 - 0.0337
1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
0.0078
1-[4-(methylsulfonyl)phenyl]-3-piperidin-1-ylpropan-1-one
Trypanosoma brucei
-
-
0.0587 - 0.0753
12-chloro-1,1-dimethyl-1,2,3,4,4a,13b-hexahydrodibenzo[2,3:6,7]thiepino[4,5-b]pyridin-1-ium
0.059
2,2'-(2-imino-1H-benzimidazole-1,3(2H)-diyl)bis(N,N-diethylethanamine)
Trypanosoma brucei
-
IC50: 0.059 mM
0.1
2-(2,4-dioxo-1,3-diazaspiro[4.6]undec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide
0.1
2-(3-benzyl-2-imino-2,3-dihydro-1H-benzimidazol-1-yl)-1-(4-chlorophenyl)ethanol
Trypanosoma brucei
-
IC50: 0.1 mM, 32% inhibition at 0.025 mM
0.1
2-(4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidinyl-1'-yl)-N,N-dimethylethanamine
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.1
2-(5-methylfuran-2-yl)-N-(2-morpholinoethyl)quinoline-4-carboxamide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0844 - 0.1
2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]dec-3-yl)-N-[2-(phenylsulfanyl)phenyl]acetamide
0.00531 - 0.0783
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
0.00093 - 0.0309
2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]-2-oxoethanaminium formate
0.00075
2-chloro-10-(3-(4-(3-phenylpropyl)piperazin-1-yl)propyl)-10H-phenothiazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.00132
2-[(4-bromophenyl)sulfanyl]-5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]aniline
Trypanosoma brucei rhodesiense
-
-
0.024
2-[2-imino-3-(2-piperidin-1-ylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-1-(4-methoxyphenyl)ethanol
Trypanosoma brucei
-
IC50: 0.024 mM, 85% inhibition at 0.025 mM
0.0319 - 0.0354
2-[3-(2-chloro-10H-phenothiazin-10-yl)-3-oxopropyl]octahydro-2H-pyrido[1,2-a]pyrazinediium
0.007
2-[3-[2-(diethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]-1-(4-methoxyphenyl)ethanone
Trypanosoma brucei
-
IC50: 0.007 mM, 91% inhibition at 0.025 mM
0.019
2-[3-[2-(diethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]-1-(4-methylphenyl)ethanol
Trypanosoma brucei
-
IC50: 0.019 mM
0.029
2-[3-[2-(dimethylamino)ethyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]-1-(4-methylphenyl)ethanol
Trypanosoma brucei
-
IC50: 0.029 mM
0.035
2-[3-[2-(dimethylamino)propyl]-2-imino-2,3-dihydro-1H-benzimidazol-1-yl]-1-(4-methylphenyl)ethanol
Trypanosoma brucei
-
IC50: 0.035 mM
0.00082 - 0.112
2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
0.00088 - 0.18
2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
0.0003
3,3'-[butane-1,4-diylbis[(3-aminopropyl)imino]]bis(N-[5-chloro-2-[(4-methoxyphenyl)sulfanyl]phenyl]propanamide)
Trypanosoma cruzi
-
IC50: 0.0003 mM
0.0367 - 0.0373
3-(11H-dibenzo[b,e][1,4]dithiepin-11-yl)-N,N-dimethylpropan-1-aminium
0.0115 - 0.0146
3-(11H-dibenzo[b,e][1,4]oxathiepin-11-ylmethyl)-1-methylpiperidinium
0.0033
3-(3,4-dichlorophenyl)-N,N-dimethyl-3-oxopropan-1-aminium chloride
Trypanosoma brucei
-
-
0.1
3-(5-bromo-2-fluorophenyl)-1-butyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
3-(5-bromo-2-fluorophenyl)-1-cyclopentyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0102
3-(5-bromo-2-fluorophenyl)-1-ethyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
3-(5-bromo-2-fluorophenyl)-1-[2-(dimethylamino)ethyl]-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.05
3-(5-bromo-2-fluorophenyl)-6-methyl-1-(propan-2-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
IC50 above 0.05 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
3-(5-bromo-2-fluorophenyl)-6-methylpyrimido[5,4-e,1,2,4]triazine-5,7(1H,6H)dione
Trypanosoma brucei
-
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.092
3-(5-bromo-2-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.013
3-(5-bromothiophen-2-yl)-1-ethyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
3-(methylsulfanyl)-5-phenyl-1,2,4-triazine
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.000068 - 0.00068
3-([2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
0.000077 - 0.00077
3-([5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]amino)-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
0.015
3-benzyl-1-[2-(7-chloro-quinolin-4-ylamino)-ethyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea
Trypanosoma cruzi
-
-
0.0032
3-Benzyl-1-[3-(7-chloro-quinolin-4-ylamino)-propyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea
Trypanosoma cruzi
-
-
0.0033
3-Benzyl-1-[4-(7-chloro-quinolin-4-ylamino)-butyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea
Trypanosoma cruzi
-
-
0.0024
3-Benzyl-1-[6-(7-chloro-quinolin-4-ylamino)-hexyl]-1-[2-(N'',N''-dimethylaminomethyl)-ferrocenylmethyl]urea
Trypanosoma cruzi
-
-
0.0065
3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine
Trypanosoma cruzi
-
IC50: 0.0065 mM
0.052
3-cyano-1-azabicyclo[2.2.2]oct-3-yl acetate
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.027
3-methoxy-3'-(methylsulfanyl)-5,5'-bi-1,2,4-triazine
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.1
3-Phenylpropylamine
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0015
3-[(2,3-dimethylphenyl)amino]-1-(3-nitrophenyl)propan-1-one
Trypanosoma brucei
-
-
0.0033
3-[(3-fluorophenyl)amino]-1-(3-nitrophenyl)propan-1-one
Trypanosoma brucei
-
-
0.000102 - 0.00102
3-[(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
0.000059 - 0.00059
3-[[5-chloro-2-(phenylsulfanyl)phenyl]amino]-N,N-dimethyl-N-[(5-nitrofuran-2-yl)methyl]propan-1-aminium bromide
0.019
4'-(benzo[b]thiophen-2-yl)-1'-benzyl-1,4'-bipiperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.00093
4'-(benzo[b]thiophen-2-yl)-1'-methyl-1,4'bipiperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.0051
4'-(benzo[b]thiophen-2-yl)-[1,4']bipiperidine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.017
4,6,8-trimethyl-N-(4,4,6-trimethyl-1,4-dihydropyrimidin-2-yl)quinazolin-2-amine
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.0517
4-(2-(([1,1'-biphenyl]-4-ylmethyl)amino)-N-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-4-(dimethylamino)-7Hpyrrolo[2,3-d]pyrimidine-6-carboxamido)butan-1-aminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.0044
4-(2-(4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidin-1'-yl)ethyl)morpholine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.0388
4-(azepan-1-ylmethyl)-2,6-di-tert-butylphenol
Trypanosoma brucei
-
-
0.0522
4-(N-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-4-(dimethylamino)-2-((2-(naphthalen-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamido)butan-1-aminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.0946
4-(N-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-4-(dimethylamino)-2-((3-phenylpropyl)amino)-7H-pyrrolo-[2,3-d]pyrimidine-6-carboxamido)butan-1-aminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.1002
4-(N-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-4-(dimethylamino)-2-(phenethylamino)-7H-pyrrolo[2,3-d]-pyrimidine-6-carboxamido)butan-1-aminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.000251
4-chloromercuribenzoic acid
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.00058
4-[(7-chloro-4-nitro-2,1,3-benzothiadiazol-5-yl)sulfanyl]quinazoline
Trypanosoma brucei brucei
-
pH 7.5, 22°C
0.0118
4-[(dimethylamino)methyl]-2,6-bis(1-methylethyl)phenol
Trypanosoma brucei
-
-
0.011
4-[1-(1-benzothiophen-2-yl)cyclohexyl]morpholine
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.00121 - 0.0268
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
0.001 - 0.0246
4-[2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-2-oxoethyl]-1-methyl-1-[(5-nitrofuran-2-yl)methyl]piperazin-1-ium formate
0.1
4-[6-[(3-chlorophenyl)carbamoyl]-4-oxo-1,4,5,6-tetrahydropyrimidin-2-yl]-1-methylpiperazin-1-ium
0.1
5,6-dimethyl-2-[(4,6,8-trimethylquinazolin-2-yl)amino]pyrimidin-4-ol
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.00061
5,7-dichloro-4-nitro-2,1,3-benzothiadiazole
Trypanosoma brucei brucei
-
pH 7.5, 22°C
0.0297
5-(2-chloroethoxy)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.00097
5-chloro-2-[(4-chlorophenyl)sulfanyl]-N-[3-(4-methylpiperazin-1-yl)propyl]aniline
Trypanosoma brucei rhodesiense
-
-
0.0007
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[(2-naphthalen-1-ylphenyl)sulfanyl]aniline
Trypanosoma brucei rhodesiense
-
-
0.0007
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[(2-naphthalen-2-ylphenyl)sulfanyl]aniline
Trypanosoma brucei rhodesiense
-
-
0.0009
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[[2-(trifluoromethyl)phenyl]sulfanyl]aniline
Trypanosoma brucei rhodesiense
-
-
0.00106
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[[3-(trifluoromethyl)phenyl]sulfanyl]aniline
Trypanosoma brucei rhodesiense
-
-
0.00203
5-chloro-N-[3-(4-methylpiperazin-1-yl)propyl]-2-[[4-(trifluoromethyl)phenyl]sulfanyl]aniline
Trypanosoma brucei rhodesiense
-
-
0.0085
5-nitrofuran-2-carbaldehyde N-butylsemicarbazone
Trypanosoma cruzi
-
-
0.0063 - 0.035
5-[2-(1-benzothiophen-5-yl)-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-3-yl]-1H-indole
-
0.0043 - 0.01
5-[2-phenyl-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-3-yl]-1H-indole
-
0.0048 - 0.02
5-[3-(1-benzothiophen-5-yl)-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
-
0.0056 - 0.025
5-[3-phenyl-5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
-
0.004 - 0.012
5-[5-[1-(pyrrolidin-1-yl)cyclohexyl]thiophen-2-yl]-1H-indole
-
0.1
6-(naphthalen-2-ylamino)-6-oxohexane-1,5-diaminium
0.0042
6-bromo-2-(5-methylfuran-2-yl)-N-(2-morpholinoethyl)quinoline-4-carboxamide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0084
6-bromo-2-(5-methylfuran-2-yl)-N-(4-sulfamoylbenzyl)quinoline-4-carboxamide
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
6-bromo-2-(5-methylfuran-2-yl)-N-(morpholin-4-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0047
6-bromo-2-(5-methylfuran-2-yl)-N-(pyridin-2-ylmethyl)quinoline-4-carboxamide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0072
6-bromo-2-(5-methylfuran-2-yl)-N-(pyridin-3-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
6-bromo-2-(5-methylfuran-2-yl)-N-phenethylquinoline-4-carboxamide
Trypanosoma brucei
-
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0012
6-bromo-N,N,N-trimethyl-2-(2-(5-methylfuran-2-yl)quinoline-4-carboxamido)ethanaminium iodide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0017
6-bromo-N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
6-bromo-N-(2-(dimethylamino)ethyl)-2-(5-methylthiophen-2-yl)-quinoline-4-carboxamide
Trypanosoma brucei
-
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0324
6-bromo-N-(2-(dimethylamino)ethyl)-2-(furan-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0011
6-bromo-N-(2-(methylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
6-bromo-N-(furan-2-ylmethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0963
6-bromo-N-[2-(dimethylamino)ethyl]-2-(pyridin-4-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
6-bromo-N-[2-(dimethylamino)ethyl]-2-phenylquinoline-4-carboxamide
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0051 - 0.1
6-bromo-N-[3-(1H-imidazol-1-ylamino)propyl]-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
0.0116
6-chloro-2-(5-methylfuran-2-yl)-N-[3-(morpholin-4-yl)propyl]quinoline-4-carboxamide
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0265
6-chloro-N-[2-(dimethylamino)ethyl]-3-methyl-2-(4-methylphenyl)quinoline-4-carboxamide
Trypanosoma brucei
-
in 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.028
7-ethoxy-4-methyl-N-(4,4,6-trimethyl-4,5-dihydropyrimidin-2-yl)quinazolin-2-amine
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.032
7-ethyl-4-methyl-N-(4,4,6-trimethyl-4,5-dihydropyrimidin-2-yl)quinazolin-2-amine
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.00039 - 0.019
7-methoxy-N-[2-([[2-(4-methylpiperazin-1-yl)ethyl]amino]methyl)-3-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl]-4a,9a-dihydroacridin-2-amine
0.0051
8-bromo-N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.0408
Ac-PEIIQSVGISMKM-NH2
Leishmania infantum
pH and temperature not specified in the publication
0.0336
Ac-PEIIQSVGISNLKNL-NH2
Leishmania infantum
pH and temperature not specified in the publication
0.0179
Ac-PKIIQSVGISMKM-NH2
Leishmania infantum
pH and temperature not specified in the publication
0.0157
Ac-PKIIQSVGISNLKNL-NH2
Leishmania infantum
pH and temperature not specified in the publication
0.0043
altenusin
Trypanosoma cruzi
-
-
0.0904
aspidospermine
Leishmania amazonensis
-
-
0.0066
Au(2-(2'-pyridyl)benzimidazole)Cl2
Leishmania infantum
-
at pH 7.5 and 25°C
-
0.0061
Au-(N-(1-hydroxy-3-methylbutan-2-yl)pyridine-2-carboxamide)Cl
Leishmania infantum
-
at pH 7.5 and 25°C
-
0.0101
AuCl3
Leishmania infantum
-
at pH 7.5 and 25°C
0.0005
auranofin
Leishmania infantum
-
at pH 7.5 and 25°C
0.00494
Bay 11-7085
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.1
benzo[b]thiophen-2-yl(1-(piperidin-1-yl)cyclohexyl)methanone
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.0021
bromoacetyl alprenolol menthane
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0024
butyl 4-[[3-(3-nitrophenyl)-3-oxopropyl]amino]benzoate
Trypanosoma brucei
-
-
0.0063
chlorpromazine
Trypanosoma cruzi
pH and temperature not specified in the publication
0.00632
chlorpromazoine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.029
cis-3-oxo-8,9b-bis-(trans-N-(acrylamidospermidyl))-1,2,3,4,4a,9b-hexahydrodibenzofuran
Lunaria biennis
-
IC50: 0.029 mM
0.056
cis-3-oxo-8-trans-(N-acrylamidospermidyl)-9b-trans-ethylacrylyl-1,2,3,4,4a,9b-hexahydrodibenzofuran
Lunaria biennis
-
IC50: 0.056 mM
0.0823
citalopram
Trypanosoma brucei
in 40 mM HEPES, pH 7.4, 1 mM EDTA
0.0038 - 0.0111
clomipramine
0.1
diphenyl(1-(piperidin-1-yl)cyclohexyl)methanol
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.00018 - 0.00136
ebselen
0.004
heptyl (2E)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinecarboxylate
Trypanosoma cruzi
-
-
0.0036
hexyl (2E)-2-[(5-nitrofuran-2-yl)methylidene]hydrazinecarboxylate
Trypanosoma cruzi
-
-
0.0008 - 0.0025
hypnophilin
0.00726 - 0.00884
indatraline
0.0527
K[Au(saccharine)2]
Leishmania infantum
-
at pH 7.5 and 25°C
0.0149
K[Au(saccharine)4]
Leishmania infantum
-
at pH 7.5 and 25°C
0.065
lunarine
Lunaria biennis
-
IC50: 0.065 mM
0.0129 - 0.01699
Mepacrine
0.00061 - 0.0243
N'-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N,N-dimethylethane-1,2-diamine
0.00206
N'-(5-chloro-2-[[2-(trifluoromethyl)phenyl]sulfanyl]phenyl)-N,N-dimethylpropane-1,3-diamine
Trypanosoma brucei rhodesiense
-
-
0.00116
N'-(5-chloro-2-[[4-(trifluoromethyl)phenyl]sulfanyl]phenyl)-N,N-dimethylpropane-1,3-diamine
Trypanosoma brucei rhodesiense
-
-
0.00233
N'-[2-[(4-bromophenyl)sulfanyl]-5-chlorophenyl]-N,N-dimethylpropane-1,3-diamine
Trypanosoma brucei rhodesiense
-
-
0.001 - 0.0342
N'-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N,N-dimethylethane-1,2-diamine
0.00189
N'-[5-chloro-2-(naphthalen-1-ylsulfanyl)phenyl]-N,N-dimethylpropane-1,3-diamine
Trypanosoma brucei rhodesiense
-
-
0.00162
N'-[5-chloro-2-(naphthalen-2-ylsulfanyl)phenyl]-N,N-dimethylpropane-1,3-diamine
Trypanosoma brucei rhodesiense
-
-
0.001144
N'-[5-chloro-2-[(4-chlorophenyl)sulfanyl]phenyl]-N,N-dimethylpropane-1,3-diamine
Trypanosoma brucei rhodesiense
-
-
0.0183
N,N'-(4,4'-diselanediylbis[4,1-phenylene])bisadamantamide
Leishmania infantum
pH 8.0, 26°C
-
0.014
N,N'-(4,4'-diselanediylbis[4,1-phenylene])bisfuran-2-carboxamide
Leishmania infantum
pH 8.0, 26°C
-
0.00553
N,N'-(4,4'-diselanediylbis[4,1-phenylene])bisnaphthamide
Leishmania infantum
pH 8.0, 26°C
-
0.0485
N,N'-(furan-2,5-diyldibenzene-4,1-diyl)diacetamide
Trypanosoma cruzi
-
IC50: 0.0485 mM, 54% inhibition at 0.02 mg/ml
0.1
N,N-diethyl-2-(2-imino-3-prop-2-en-1-yl-2,3-dihydro-1H-benzimidazol-1-yl)ethanamine
Trypanosoma brucei
-
IC50: 0.1 mM, 31% inhibition at 0.025 mM
0.008
N,N-diethyl-2-[2-imino-3-(2-phenoxyethyl)-2,3-dihydro-1H-benzimidazol-1-yl]ethanamine
Trypanosoma brucei
-
IC50: 0.008 mM
0.00034
N,N-dimethyl-3-(3-nitrophenyl)-3-oxopropan-1-aminium chloride
Trypanosoma brucei
-
-
0.0029
N,N-dimethyl-3-[4-(methylsulfonyl)phenyl]-3-oxopropan-1-aminium chloride
Trypanosoma brucei
-
-
0.0144
N-(2-(dimethylamino)ethyl)-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
N-(2-(dimethylamino)ethyl)-6-fluoro-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
N-(2-phenoxyethyl)-N'-(2-piperidin-1-ylethyl)benzene-1,2-diamine
Trypanosoma brucei
-
IC50: 0.1 mM
0.0002 - 0.0093
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-2-(4-methylpiperazin-1-yl)acetamide
0.0016 - 0.104
N-(2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-[[4-(trifluoromethyl)phenyl]sulfanyl]benzyl)-N2,N2-dimethylglycinamide
0.006 - 0.0469
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(naphthalen-1-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
0.00179 - 0.0566
N-(3,4-dichlorobenzyl)-2-([2-[(7-methoxy-8a,10a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]amino)-N,N-dimethyl-2-oxoethanaminium
0.0024
N-(3,5-di-tert-butyl-4-hydroxybenzyl)-2-hydroxyethanaminium chloride
Trypanosoma brucei
-
-
0.1
N-(4,6-dimethylpyrimidin-2-yl)-4,5,7-trimethylquinazolin-2-amine
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.1
N-(4,6-dimethylpyrimidin-2-yl)-4,6-dimethylquinazolin-2-amine
Trypanosoma cruzi
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.0027
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-butane-1,4-diamine
Trypanosoma cruzi
-
-
0.0476
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-ethane-1,2-diamine
Trypanosoma cruzi
-
-
0.0021
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-hexane-1,6-diamine
Trypanosoma cruzi
-
-
0.0068
N-(7-Chloro-quinolin-4-yl)-N'-[2-(N'',N''-dimethyl-aminomethyl)ferrocenylmethyl]-propane-1,3-diamine
Trypanosoma cruzi
-
-
0.00028 - 0.0116
N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
0.1
N-benzyl-6-bromo-2-(5-methylfuran-2-yl)quinoline-4-carboxamide
Trypanosoma brucei
-
IC50 above 0.1 mM, 40 mM HEPES, 1 mM EDTA, pH 7.4, at 22°C
0.1
N-[(2E)-1-(2-phenoxyethyl)-3-(2-piperidin-1-ylethyl)-1,3-dihydro-2H-benzimidazol-2-ylidene]acetamide
Trypanosoma brucei
-
IC50: 0.1 mM
0.033
N-[(4-chlorophenyl)(phenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octan-3-imine
Trypanosoma cruzi
-
in 40 mM HEPES, 1 mM EDTA, 0.01% (v/v) bovine serum albumin, 0.05% (v/v) Tween 20, pH 7.5, 22°C
0.1
N-[2-(phenylsulfanyl)phenyl]-2-[(phenylsulfonyl)amino]propanamide
0.1
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)acetamide
0.0368
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-2-phenylacetamide
Trypanosoma cruzi
-
IC50: 0.0368 mM
0.0445
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]-4-nitrobenzamide
Trypanosoma cruzi
-
IC50: 0.0445 mM
0.0496
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]benzamide
Trypanosoma cruzi
-
IC50: 0.0496 mM
0.0305
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]butanamide
Trypanosoma cruzi
-
IC50: 0.0305 mM
0.0316
N-[2-[(4-chlorophenyl)sulfanyl]phenyl]propanamide
Trypanosoma cruzi
-
IC50: 0.0316 mM
0.00102 - 0.0093
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
0.00274 - 0.121
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(naphthalen-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
0.00063 - 0.0158
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-2-(4-methylpiperazin-1-yl)acetamide
0.00091 - 0.0576
N-[2-[(7-methoxy-4a,9a-dihydroacridin-2-yl)amino]-6-(pyridin-2-ylsulfanyl)benzyl]-N2,N2-dimethylglycinamide
0.0224
N1-((1-(3-(2-(2-oxoimidazolidin-1-yl)ethoxy)-4-(4-phenethylthiazol-2-yl)phenyl)-1H-imidazol-2-yl)methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.0051
N1-((1-(4-(4-(2-(naphthalen-2-yl)ethyl)thiazol-2-yl)-3-(2-(2-oxoimidazolidin-1-yl)ethoxy)phenyl)-1H-imidazol-2-yl)-methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.0086
N1-((1-(4-(4-(2-([1,1'-biphenyl]-4-yl)ethyl)thiazol-2-yl)-3-(2-(2-oxoimidazolidin-1-yl)ethoxy)phenyl)-1H-imidazol-2-yl)methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.0328
N1-((1-(4-(4-benzylthiazol-2-yl)-3-(2-(2-oxoimidazolidin-1-yl)ethoxy)phenyl)-1H-imidazol-2-yl)methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.0512
N1-((1-(4-(4-isobutylthiazol-2-yl)-3-(2-(2-oxoimidazolidin-1-yl)ethoxy)phenyl)-1H-imidazol-2-yl)methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.0513
N1-((1-(4-(4-neopentylthiazol-2-yl)-3-(2-(2-oxoimidazolidin-1-yl)ethoxy)phenyl)-1H-imidazol-2-yl)methyl)ethane-1,2-diaminium 2,2,2-trifluoroacetate
Leishmania infantum
pH 6.0, 26°C
-
0.0078
nifurtimox
Trypanosoma cruzi
-
-
0.0389
panepoxydone
Trypanosoma cruzi
-
-
0.00488
perphenazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.1
phenyl(1-(piperidin-1-yl)cyclohexyl)methanone
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.00689
pindobind
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0012
PKIIQSVGICMKM
Leishmania infantum
pH 6.0, 26°C
-
0.0074 - 0.00746
prochlorperazine
0.0221
Quinacrine
Trypanosoma brucei
in 40 mM HEPES, pH 7.4, 1 mM EDTA
0.1
tert-butyl 4'-(benzo[b]thiophen-2-yl)-1,4'-bipiperidine-1'-carboxylate
Trypanosoma brucei
-
IC50 above 0.1 mM, in 40 mM HEPES, 1 mM EDTA (pH 7.4)
0.00958
thioridazine
Trypanosoma brucei
in 40 mM HEPES, pH 7.4, 1 mM EDTA
0.173
trans-4-[3-(3,4-dichlorophenyl)indan-1-yl]morpholine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.00307
trans-benzyl-[3-(3,4-dichlorophenyl)-6-methoxyindan-1-yl]amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.2
trans-N-[3-(3,4-dichlorophenyl)indan-1-yl]-4-methylbenzenesulfonamide
Trypanosoma brucei
-
IC50 above 0.2 mM, in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.2
trans-N-[3-(3,4-dichlorophenyl)indan-1-yl]acetamide
Trypanosoma brucei
-
IC50 above 0.2 mM, in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.00315
trans-[3-(3,4-dibromophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.00223
trans-[3-(3,4-dichlorophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.0459
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(3,4-dichlorobenzyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.00405
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(3-methylbutyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.00494
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-aminobenzyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.0176
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-chlorobenzyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.00738
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-dimethylaminobenzyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.00414
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-methoxybenzyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.013
trans-[3-(3,4-dichlorophenyl)indan-1-yl]-(4-methylbenzyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.00793
trans-[3-(3,4-dichlorophenyl)indan-1-yl]octylamine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.0158
trans-[3-(4-chlorophenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)-amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.125
trans-[3-(4-methoxyphenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.0329
trans-[3-(4-methylphenyl)-6-methoxyindan-1-yl]-(3-methylbutyl)-amine
Trypanosoma brucei
-
in 40 mM HEPES (pH 7.5), temperature not specified in the publication
0.0405
Trifluoperazine
Trypanosoma brucei
in 40 mM HEPES, pH 7.4, 1 mM EDTA
0.00753
triflupromazine
Trypanosoma brucei
-
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C
0.0075
triflupromizine
Trypanosoma cruzi
pH and temperature not specified in the publication
-
0.0088
[(2,2'-bipyridine)Au(OH)2][PF6]
Leishmania infantum
-
at pH 7.5 and 25°C
-
0.00505
[Au((S)-4-Bn-2-(pyridin-2-yl)-4,5-dihydro-oxazole)Cl2][PF6]
Leishmania infantum
-
at pH 7.5 and 25°C
-
0.0014
[Au((S)-4-iPr-2-(pyridin-2-yl)-4,5-dihydro-oxazole)Cl2][PF6]
Leishmania infantum
-
at pH 7.5 and 25°C
-
0.0228
[Au2(bipy)2(m-O)2](PF6)2
Leishmania infantum
-
at pH 7.5 and 25°C
-
0.0006
[Cl2AuIII(2-(2'-pyridyl)benzimidazole)AuI(PPh3)](PF6)
Leishmania infantum
-
at pH 7.5 and 25°C
-
0.00027
[[(7-nitro-2,1,3-benzoxadiazol-4-yl)methyl]sulfanyl]methyl phenylcarbamate
Trypanosoma brucei brucei
-
pH 7.5, 22°C