1.8.1.14: CoA-disulfide reductase

This is an abbreviated version!
For detailed information about CoA-disulfide reductase, go to the full flat file.

Reaction

2 CoA +

Synonyms

BACoADR, BB0728, CoA disulfide reductase, CoA-disulfide reductase (NADH), CoA-disulfide reductase (NADH2), CoADR, coenzyme A disulfide reductase, coenzyme A disulphide reductase, coenzyme A-disulfide reductase, EC 1.6.4.10, NADH-dependent coenzyme A disulfide reductase, NADH2:CoA-disulfide oxidoreductase, NADH:CoA-disulfide oxidoreductase, PH0572

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.1 With NAD⁺ or NADP⁺ as acceptor

                1.8.1.14 CoA-disulfide reductase

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Results	in table
1995	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
37	Cofactor
8	Crystallization (Commentary)
5	General Information
7	Inhibitors
8	kcat/KM [mM/s]
7	Ki Value [mM]
27	KM Value [mM]
2	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
25	Organism
2	Pathway
27	PDB ID
1	pH Optimum
12	Protein Variants
10	Purification (Commentary)
2	Reaction
3	Reaction Type
23	Reference
2	Source Tissue
4	Specific Activity [micromol/min/mg]
42	Substrates and Products (Substrate)
8	Subunits
48	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
35	Turnover Number [1/s]

Crystallization

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Crystallization on EC 1.8.1.14 - CoA-disulfide reductase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

crystal structure at 2.30 A resolution. The structures of the NADH and NADPH complexes at ca. 2.3 A resolution reveal that a loop consisting of residues Glu180-Thr187 becomes ordered and changes conformation on NAD(P)H binding

Bacillus anthracis

-

685242

sitting drop vapor diffusion method, using 16-26% 2-methyl-2,4-pentanediol, 0.2 M magnesium acetate, and 0.1 M sodium cacodylate, pH 6.5, at 15°C

Bacillus anthracis

-

685242

hanging and sitting drop vapor diffusion method

Pyrococcus horikoshii

O58308

744312

hanging drop and sitting drop vapor diffusion methods, using 100 mM Tris, pH 8.0, 2-3 M 1,6-hexanediol, and 200 mM MgCl2

Pyrococcus horikoshii

O58308

724377

sitting drop vapor diffusion method at room temperature

Pyrococcus horikoshii

O58308

764676

hanging drop vapour diffusion method

Staphylococcus aureus

O52582

672062

sitting drop vapor diffusion method, using 35-37% (w/v) PEG 600, 0.3-0.4 M MgCl2, and 0.1 M HEPES, pH 7.5 (mutants Y361F and Y419F), or 27% (w/v) PEG 600, 0.4 M MgCl2, pH 7.2 (mutant Y361F/Y419F), or 31% (w/v) PEG 600, 0.4 M MgCl2, and 0.1 M HEPES, pH 7.2 (mutant C43S)

Staphylococcus aureus

Q2FIA5

724355

crystallization by vapor diffusion. X-ray structure is determined at 2.9 A resolution

Thermus thermophilus

Q72HK3

764212