1.8.3.7: formylglycine-generating enzyme
This is an abbreviated version!
For detailed information about formylglycine-generating enzyme, go to the full flat file.
Word Map on EC 1.8.3.7
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1.8.3.7
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sulfatases
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metachromatic
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mucopolysaccharidosis
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leukodystrophy
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ichthyosis
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antibody-drug
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ultra-rare
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morquio
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medicine
- 1.8.3.7
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sulfatases
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metachromatic
- mucopolysaccharidosis
- leukodystrophy
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ichthyosis
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antibody-drug
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ultra-rare
- morquio
- medicine
Reaction
Synonyms
AtsB, C-alpha-formylglycine-generating enzyme 1, Calpha-formylglycine-generating enzyme, Calpha-formylglycine-generating enzyme 1, FGE, FGly-generating enzyme, formylglycine generating enzyme, sulfatase-modifying factor 1, SUMF1
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Application
Application on EC 1.8.3.7 - formylglycine-generating enzyme
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biotechnology
medicine
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coexpression of formylglycine-generating enzyme is essential for gene therapy of metachromatic leukodystrophy
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bioconjugation chemistry, formylglycine-generating enzymes catalyze the site-specific oxidation of a cysteine residue to the aldehyde-containing amino acid Ca-formylglycine (FGly). This noncanonical residue can be generated within any desired target protein and can subsequently be used for bioorthogonal conjugation reactions
biotechnology
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site-specific bioconjugation. Formylglycine-generating enzymes allow to posttranslationally introduce the amino acid Calpha-formylglycine (FGly) into recombinant proteins, starting from cysteine or serine residues within distinct consensus motifs
biotechnology
site-specific bioconjugation. Formylglycine-generating enzymes allow to posttranslationally introduce the amino acid Calpha-formylglycine (FGly) into recombinant proteins, starting from cysteine or serine residues within distinct consensus motifs
biotechnology
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site-specific conjugation strategy for dual antibody-drug conjugates using aerobic formylglycine-generating enzymes
biotechnology
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site-specific conjugation strategy for dual antibody-drug conjugates using aerobic formylglycine-generating enzymes
biotechnology
site-specific conjugation strategy for dual antibody-drug conjugates using aerobic formylglycine-generating enzymes
biotechnology
the enzyme is an enabling biotechnology tool due to the robust utility of the aldehyde product as a bioconjugation handle in recombinant proteins
biotechnology
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the enzyme is an enabling biotechnology tool due to the robust utility of the aldehyde product as a bioconjugation handle in recombinant proteins
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