18.104.22.168: adenylyl-sulfate reductase (thioredoxin)
This is an abbreviated version!
For detailed information about adenylyl-sulfate reductase (thioredoxin), go to the full flat file. Reaction
thioredoxin disulfide +
5'-adenylyl sulfate thioredoxin Synonyms
5'-adenylylsulfate reductase, adenosine-5'-phosphosulfate reductase, adenylylsulfate reductase, APR, APR-B, APS reductase, PaAPR, PpAPR-B, thioredoxin dependent 5'-adenylylsulfate reductase, thioredoxin-dependent APS reductase
Inhibitors on EC 22.214.171.124 - adenylyl-sulfate reductase (thioredoxin)
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best inhibitor analyzed. The S atom is capable of establishing favorable interactions with the Fe-S cluster
competitive vs. adenosine-5'-phosphosulfate
development of a roadmap for rational design of small molecules as potential inhibitors of APS reductase
analysis of inhibitors and molecular docking shows a clearly defined spacing requirement between the Fe-S targeting group and adenosine scaffold. Smaller Fe-S targeting groups are better tolerated. The S atom of the most potent inhibitor may establish a favorable interaction with an S atom in the cluster
not inhibited by 3'-AMP