1.8.4.10: adenylyl-sulfate reductase (thioredoxin)

This is an abbreviated version!
For detailed information about adenylyl-sulfate reductase (thioredoxin), go to the full flat file.

Word Map on EC 1.8.4.10

Reaction

AMP
+
sulfite
+
thioredoxin disulfide
=
5'-adenylyl sulfate
+
thioredoxin

Synonyms

5'-adenylylsulfate reductase, adenosine-5'-phosphosulfate reductase, adenylylsulfate reductase, APR, APR-B, APS reductase, PaAPR, PpAPR-B, thioredoxin dependent 5'-adenylylsulfate reductase, thioredoxin-dependent APS reductase

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.4 With a disulfide as acceptor
                1.8.4.10 adenylyl-sulfate reductase (thioredoxin)

Substrates Products

Substrates Products on EC 1.8.4.10 - adenylyl-sulfate reductase (thioredoxin)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenosine-5'-phosphosulfate + thioredoxin
? + thioredoxin disulfide
show the reaction diagram
substrate of phosphoadenylyl-sulfate reductase, EC 1.8.4.8
-
-
?
5'-adenylyl sulfate + glutathione
AMP + sulfite + glutathione disulfide
show the reaction diagram
enzyme contains a C-terminal thioredoxin-like PDI domain, physiological electron acceptor unknown
-
?
5'-adenylyl sulfate + reduced dithiothreitol
AMP + sulfite + oxidized dithiothreitol
show the reaction diagram
enzyme contains a C-terminal thioredoxin-like PDI domain, physiological electron acceptor unknown
-
?
5'-adenylyl sulfate + thioredoxin
AMP + sulfite + thioredoxin disulfide
show the reaction diagram
adenosine 5'-phosphosulfate + thioredoxin
AMP + sulfite + thioredoxin disulfide
show the reaction diagram
-
noncovalent complexes of the holoprotein with several ligands, including adenosine 5'-phosphosulfate, thioredoxin, and AMP, are investigated. AMP binds with a higher affinity to the enzyme intermediate than to the free enzyme
-
-
?
adenylyl sulfate + thioredoxin
AMP + sulfite + thioredoxin disulfide
show the reaction diagram
additional information
?
-