1.8.4.11: peptide-methionine (S)-S-oxide reductase

This is an abbreviated version!
For detailed information about peptide-methionine (S)-S-oxide reductase, go to the full flat file.

Reaction

L-methionine (S)-sulfoxide
+
thioredoxin
=
L-methionine
+
thioredoxin disulfide
+
H2O

Synonyms

ecdysone-induced protein 28/29 kDa, FMsr, LMJF_07_1140, methionine S-oxide reductase (S-form oxidizing), methionine sulfoxide reductase, methionine sulfoxide reductase A, methionine sulfoxide reductases A, methionine sulfoxide-S-reductase, methionine sulphoxide reductase, methionine sulphoxide reductase A, methionine-S-sulfoxide reductase, MetSO-L12 reductase, More, mrsA, MSR, MSR10, MSR180, MsrA, MSRA-1, MsrA/B, MsrA/MsrB, MSRA2, MSRA4, MsrABTk, MsrBA, Peptide Met(O) reductase, peptide methionine S-sulfoxide reductase, peptide methionine sulfoxide reductase, peptide methionine sulfoxide reductase A, peptide methionine sulfoxide reductase type A, peptide methionine sulphoxide reductase, peptide-methionine (S)-S-oxide reductase, peptide-methionine sulfoxide reductase, PilA, PilB, PilB protein, PMSR, PMSRA, protein-methionine-S-oxide-reductase, sulindac reductase

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.4 With a disulfide as acceptor
                1.8.4.11 peptide-methionine (S)-S-oxide reductase

Expression

Expression on EC 1.8.4.11 - peptide-methionine (S)-S-oxide reductase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme expression is declined gradually when the plants are exposed to high salt, H2O2 and absisic acid conditions and decrease to lower level at 12 h
-
induced expression under various stresses, regulated directly by the stress-responsive extracytoplasmic-function sigma factor SigH
msra-1 mRNA is increased by 2fold in daf-2 mutants compared to wild type controls when worms are cultured at 23 and 25°C, there is a notorious increase in MSRA-1 activity in daf-2 mutants as the worms age, at 23°C MSRA-1 expression is dramatically enhanced in the nervous system
serum anti-MSRA levels are significantly elevated in systemic sclerosis patients with pulmonary fibrosis, cardiac involvement, or decreased total antioxidant power compared with those without them
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the expression is slightly up-regulated in a time-dependent manner after treatment with low temperature and drought within 12 h
-
the transcript level of isoform MSRA2 is significantly accumulated in both leaves and green fruits after ethephon treatment
the upstream (promoter 1) regulates the msrA1 transcript that codes for the mitochondrial form of MSRA, the downstream promoter (promoter 2) regulates the msrA2/3 transcripts that code for the cytosolic/nuclear forms of MSRA and is generally less active, both promoters are partially regulated by all-trans retinoic acid
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