1.8.4.11: peptide-methionine (S)-S-oxide reductase

This is an abbreviated version!
For detailed information about peptide-methionine (S)-S-oxide reductase, go to the full flat file.

Reaction

L-methionine (S)-sulfoxide
+
thioredoxin
=
L-methionine
+
thioredoxin disulfide
+
H2O

Synonyms

ecdysone-induced protein 28/29 kDa, FMsr, LMJF_07_1140, methionine S-oxide reductase (S-form oxidizing), methionine sulfoxide reductase, methionine sulfoxide reductase A, methionine sulfoxide reductases A, methionine sulfoxide-S-reductase, methionine sulphoxide reductase, methionine sulphoxide reductase A, methionine-S-sulfoxide reductase, MetSO-L12 reductase, More, mrsA, MSR, MSR10, MSR180, MsrA, MSRA-1, MsrA/B, MsrA/MsrB, MSRA2, MSRA4, MsrABTk, MsrBA, Peptide Met(O) reductase, peptide methionine S-sulfoxide reductase, peptide methionine sulfoxide reductase, peptide methionine sulfoxide reductase A, peptide methionine sulfoxide reductase type A, peptide methionine sulphoxide reductase, peptide-methionine (S)-S-oxide reductase, peptide-methionine sulfoxide reductase, PilA, PilB, PilB protein, PMSR, PMSRA, protein-methionine-S-oxide-reductase, sulindac reductase

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.4 With a disulfide as acceptor
                1.8.4.11 peptide-methionine (S)-S-oxide reductase

Source Tissue

Source Tissue on EC 1.8.4.11 - peptide-methionine (S)-S-oxide reductase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
high MsrA expression level
Manually annotated by BRENDA team
highest expression level of isozyme PMSRA4
Manually annotated by BRENDA team
mature, after anthesis; mature, after anthesis
Manually annotated by BRENDA team
-
primary keratinocytes, expression level at normal light and UV-light conditions
Manually annotated by BRENDA team
-
ventricle, high MsrA expression level
Manually annotated by BRENDA team
-
primary hepatocyte
Manually annotated by BRENDA team
-
human lens epithelial cell line
Manually annotated by BRENDA team
-
high MsrA expression level
Manually annotated by BRENDA team
-
embryonic cell
Manually annotated by BRENDA team
-
chronic sun exposure of human epidermis and high dose UVA irradiation of cultured human keratinocytes results in a decline of MsrA expression and/or Msr activity
Manually annotated by BRENDA team
-
EcR-deficient cell
Manually annotated by BRENDA team
-
cortical and nuclear components
Manually annotated by BRENDA team
-
nontransgenic embryonic fibroblasts lack MsrA
Manually annotated by BRENDA team
highest expression level of isozyme PMSRA3
Manually annotated by BRENDA team
germinated; germinated; germinated, highest expression level of isozyme PMSRA4
Manually annotated by BRENDA team
; highest expression level of isozyme PMSRA2; highest expression level of isozyme PMSRA5
Manually annotated by BRENDA team
-
overexpression of MsrA in human T-lymphocyte cells protects them against oxidative stress
Manually annotated by BRENDA team
-
splice variant msrA2a. Multiple MSRA variants participate in the repair of oxidized proteins in vascular smooth muscle cells mitochondria
Manually annotated by BRENDA team
additional information