1.8.4.11: peptide-methionine (S)-S-oxide reductase

This is an abbreviated version!
For detailed information about peptide-methionine (S)-S-oxide reductase, go to the full flat file.

Reaction

L-methionine (S)-sulfoxide
+
thioredoxin
=
L-methionine
+
thioredoxin disulfide
+
H2O

Synonyms

ecdysone-induced protein 28/29 kDa, FMsr, LMJF_07_1140, methionine S-oxide reductase (S-form oxidizing), methionine sulfoxide reductase, methionine sulfoxide reductase A, methionine sulfoxide reductases A, methionine sulfoxide-S-reductase, methionine sulphoxide reductase, methionine sulphoxide reductase A, methionine-S-sulfoxide reductase, MetSO-L12 reductase, More, mrsA, MSR, MSR10, MSR180, MsrA, MSRA-1, MsrA/B, MsrA/MsrB, MSRA2, MSRA4, MsrABTk, MsrBA, Peptide Met(O) reductase, peptide methionine S-sulfoxide reductase, peptide methionine sulfoxide reductase, peptide methionine sulfoxide reductase A, peptide methionine sulfoxide reductase type A, peptide methionine sulphoxide reductase, peptide-methionine (S)-S-oxide reductase, peptide-methionine sulfoxide reductase, PilA, PilB, PilB protein, PMSR, PMSRA, protein-methionine-S-oxide-reductase, sulindac reductase

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.4 With a disulfide as acceptor
                1.8.4.11 peptide-methionine (S)-S-oxide reductase

Source Tissue

Source Tissue on EC 1.8.4.11 - peptide-methionine (S)-S-oxide reductase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
high MsrA expression level
Manually annotated by BRENDA team
mature, after anthesis
Manually annotated by BRENDA team
-
primary keratinocytes, expression level at normal light and UV-light conditions
Manually annotated by BRENDA team
-
ventricle, high MsrA expression level
Manually annotated by BRENDA team
primary hepatocyte
Manually annotated by BRENDA team
-
human lens epithelial cell line
Manually annotated by BRENDA team
-
high MsrA expression level
Manually annotated by BRENDA team
-
embryonic cell
Manually annotated by BRENDA team
chronic sun exposure of human epidermis and high dose UVA irradiation of cultured human keratinocytes results in a decline of MsrA expression and/or Msr activity
Manually annotated by BRENDA team
-
EcR-deficient cell
Manually annotated by BRENDA team
-
cortical and nuclear components
Manually annotated by BRENDA team
nontransgenic embryonic fibroblasts lack MsrA
Manually annotated by BRENDA team
-
overexpression of MsrA in human T-lymphocyte cells protects them against oxidative stress
Manually annotated by BRENDA team
splice variant msrA2a. Multiple MSRA variants participate in the repair of oxidized proteins in vascular smooth muscle cells mitochondria
Manually annotated by BRENDA team
additional information