1.8.4.11: peptide-methionine (S)-S-oxide reductase

This is an abbreviated version!
For detailed information about peptide-methionine (S)-S-oxide reductase, go to the full flat file.

Reaction

L-methionine (S)-sulfoxide
+
thioredoxin
=
L-methionine
+
thioredoxin disulfide
+
H2O

Synonyms

ecdysone-induced protein 28/29 kDa, FMsr, LMJF_07_1140, methionine S-oxide reductase (S-form oxidizing), methionine sulfoxide reductase, methionine sulfoxide reductase A, methionine sulfoxide reductases A, methionine sulfoxide-S-reductase, methionine sulphoxide reductase, methionine sulphoxide reductase A, methionine-S-sulfoxide reductase, MetSO-L12 reductase, More, mrsA, MSR, MSR10, MSR180, MsrA, MSRA-1, MsrA/B, MsrA/MsrB, MSRA2, MSRA4, MsrABTk, MsrBA, Peptide Met(O) reductase, peptide methionine S-sulfoxide reductase, peptide methionine sulfoxide reductase, peptide methionine sulfoxide reductase A, peptide methionine sulfoxide reductase type A, peptide methionine sulphoxide reductase, peptide-methionine (S)-S-oxide reductase, peptide-methionine sulfoxide reductase, PilA, PilB, PilB protein, PMSR, PMSRA, protein-methionine-S-oxide-reductase, sulindac reductase

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.4 With a disulfide as acceptor
                1.8.4.11 peptide-methionine (S)-S-oxide reductase

Substrates Products

Substrates Products on EC 1.8.4.11 - peptide-methionine (S)-S-oxide reductase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-methyl 4-tolyl sulfoxide + thioredoxin
?
show the reaction diagram
ac-L-Lys-L-Asn-L-Met(O)-L-Asp-L-Lys-dinitrophenol + dithiothreitol
ac-L-Lys-L-Asn-L-Met-L-Asp-L-Lys-dinitrophenol + dithiothreitol disulfide + H2O
show the reaction diagram
-
-
-
-
?
ac-L-Lys-L-Asp-L-Met(O)-L-Asn-L-Lys-dinitrophenol + dithiothreitol
ac-L-Lys-L-Asp-L-Met-L-Asn-L-Lys-dinitrophenol + dithiothreitol disulfide + H2O
show the reaction diagram
-
-
-
-
?
ac-L-Lys-L-Asp-L-Met(O)-L-Asp-L-Lys-dinitrophenol + dithiothreitol
ac-L-L-Lys-L-Asp-L-Met-L-Asp-L-Lys-dinitrophenol + dithiothreitol disulfide + H2O
show the reaction diagram
-
-
-
-
?
ac-L-Lys-L-Phe-L-Met(O)-L-Lys-L-Lys-dinitrophenol + dithiothreitol
ac-L-Lys-L-Phe-L-Met-L-Lys-L-Lys-dinitrophenol + dithiothreitol disulfide + H2O
show the reaction diagram
-
-
-
-
?
acetyl-L-methionine-(S)-S-oxide-NHMe + thioredoxin
?
show the reaction diagram
-
-
-
-
?
acetyl-L-methionine-(S)-S-oxide-NHMe + thioredoxin
acetyl-L-methionine-NHMe + thioredoxin disulfide + H2O
show the reaction diagram
-
-
-
?
alpha-synuclein + dithiothreitol
?
show the reaction diagram
-
alpha-synuclein is oxidized at both Met1 and Met5 but not at Met116 or Met127
-
-
?
alpha-synuclein + thioredoxin disulfide + H2O
?
show the reaction diagram
-
Met1 and Met5 within alpha-synuclein are oxidized to (S)-methionine sulfoxide
-
-
?
alpha-synuclein-L-methionine (S)-S-oxide + thioredoxin
alpha-synuclein-L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
-
-
-
?
alpha1-antitrypsin + thioredoxin disulfide + H2O
?
show the reaction diagram
-
Met358 within alpha1-antitrypsin is oxidized to (S)-methionine sulfoxide
-
-
?
apolipoprotein A-I + dithiothreitol
?
show the reaction diagram
-
the myristoylated enzyme reduces the methionine sulfoxides in apolipoprotein A-I four times faster than nonmyristoylated enzyme
-
-
?
calmodulin + thioredoxin disulfide + H2O
?
show the reaction diagram
-
Met77 within calmodulin is oxidized to (S)-methionine sulfoxide
-
-
r
calmodulin L-methionine-(S)-sulfoxide + thioredoxin
calmodulin L-methionine + thioredoxin disulfide
show the reaction diagram
calmodulin-L-methionine (S)-S-oxide + thioredoxin
calmodulin-L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
-
MsrBA is able to completely reduce (i.e., repair) MetSO in the calcium regulatory protein calmodulin. The efficient repair is the coordinate activity of the two catalytic domains in the MsrBA fusion protein, which results in a 1 order of magnitude rate enhancement in comparison to those of the individual MsrA or MsrB enzyme alone
-
-
?
calmodulin-L-methionine (S)-sulfoxide + thioredoxin
calmodulin-L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
-
-
-
-
?
dabsyl-L-methionine (R)-sulfoxide + thioredoxin
dabsyl-L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
-
-
-
?
dabsyl-L-methionine (S)-S-oxide + dithiothreitol
dabsyl-L-methionine + dithiothreitol disulfide + H2O
show the reaction diagram
dabsyl-L-methionine (S)-sulfoxide + dithiothreitol
dabsyl-L-methionine + dithiothreitol disulfide
show the reaction diagram
dabsyl-L-methionine (S)-sulfoxide + dithiothreitol
dabsyl-L-methionine + dithiothreitol disulfide + H2O
show the reaction diagram
dabsyl-L-methionine (S)-sulfoxide + NADPH + H+
dabsyl-L-methionine + NADP+ + H2O
show the reaction diagram
synthetic substrate, MsrA is absolutely specific for the S-form, 7fold lower activity with NADPH compared to DTT
-
-
?
dabsyl-L-methionine (S)-sulfoxide + thioredoxin
?
show the reaction diagram
dabsyl-L-methionine (S)-sulfoxide + thioredoxin
dabsyl-L-methionine + thioredoxin disulfide
show the reaction diagram
dabsyl-L-methionine (S)-sulfoxide + thioredoxin
dabsyl-L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
dabsyl-L-methionine-(S)-S-oxide + dithiothreitol
dabsyl-L-methionine + dithiothreitol disulfide + H2O
show the reaction diagram
-
-
-
-
?
dabsyl-L-methionine-(S)-S-oxide + dithiothreitol
dabsyl-L-methionine + DTT disulfide + H2O
show the reaction diagram
-
-
-
?
dabsyl-L-methionine-(S)-S-oxide + DTT
dabsyl-L-methionine + DTT disulfide + H2O
show the reaction diagram
dabsyl-L-methionine-(S)-S-oxide + thioredoxin
dabsyl-L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
dabsyl-L-methionine-(S)-S-sulfoxide + dithiothreitol
dabsyl-L-methionine + dithiothreitol disulfide + H2O
show the reaction diagram
dabsylated L-methionine (S)-sulfoxide + thioredoxin
dabsylated L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
dimethylsulfide + thioredoxin disulfide + H2O
dimethylsulfoxide (S)-S-oxide + thioredoxin
show the reaction diagram
DL-methionine (S)-sulfoxide + thioredoxin
DL-methionine + thioredoxin disulfide + H2O
show the reaction diagram
-
enzyme MsrA is specific for the S-form, active on free and protein-bound methionine, the latter is bound more efficiently
-
-
?
Fmoc-L-methionine (S)-sulfoxide + dithiothreitol
Fmoc-L-methionine + dithiothreitol disulfide + H2O
show the reaction diagram
Gly-L-Met-Gly + dithiothreitol
?
show the reaction diagram
-
-
-
-
?
His6-Ala-Ala-Gln-MetO-Ile + DTT
His6-Ala-Ala-Gln-Met-Ile + DTT disulfide + H2O
show the reaction diagram
-
-
-
-
?
Hsp21 L-methionine S-oxide + dithiothreitol
Hsp21 L-methionine + dithiothreitol S-oxide
show the reaction diagram
L-methionine (R)-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
-
the membrane-associated isozyme reduces both R- and S-stereoisomers of methionine sulfoxide in proteins
-
-
?
L-methionine (R,S)-sulfoxide + glutathione
L-methionine + GSSG + H2O
show the reaction diagram
-
-
-
-
?
L-methionine (R,S)-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide
show the reaction diagram
L-methionine (S)-sulfoxide + 2 dithiothreitol
L-methionine + dithiothreitol disulfide + H2O
show the reaction diagram
L-methionine (S)-sulfoxide + dithiothreitol
?
show the reaction diagram
-
the myristoylated enzyme form reduces methionine sulfoxide in protein much faster than the nonmyristoylated form
-
-
?
L-methionine (S)-sulfoxide + glutaredoxin 2
L-methionine + glutaredoxin 2 disulfide + H2O
show the reaction diagram
L-methionine (S)-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
L-methionine (S)-sulfoxide + tryparedoxin I
L-methionine + tryparedoxin I disulfide + H2O
show the reaction diagram
L-methionine sulfoxide enkephalin + thioredoxin
L-methionine enkephalin
show the reaction diagram
-
membrane-bound enzyme form Mem-R,S-Msr
-
-
?
L-methionine-(S)-S-oxide + DTT
L-methionine + DTT disulfide + H2O
show the reaction diagram
stereospecific reduction, 9-fluorenylmethyl chloroformate-labeled substrate
-
-
?
L-methionine-(S)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
L-Pro-L-Met-L-Ala-L-Ile-L-Lys-L-Lys + dithiothreitol
?
show the reaction diagram
-
-
-
-
?
methionine sulfoxide in alkyl hydroperoxide reductase C + thioredoxin
methionine in alkyl hydroperoxide reductase C + thioredoxin disulfide + H2O
show the reaction diagram
-
-
-
-
?
N-acetyl-L-methionine (R)-sulfoxide + thioredoxin
N-acetyl-L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
-
the membrane-associated isozyme reduces both R- and S-stereoisomer of methionine sulfoxide in proteins
-
-
?
N-acetyl-L-methionine (R,S)-sulfoxide + thioredoxin
N-acetyl-L-methionine + thioredoxin disulfide
show the reaction diagram
N-acetyl-L-methionine (S)-sulfoxide + thioredoxin
N-acetyl-L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
N-acetyl-L-methionine (S)-sulfoxide methyl ester + thioredoxin
N-acetyl-L-methionine methyl ester + thioredoxin disulfide + H2O
show the reaction diagram
-
enzyme MsrA
-
-
?
N-acetyl-L-methionine-(S)-S-oxide + DTT
N-acetyl-L-methionine + DTT disulfide + H2O
show the reaction diagram
N-acetyl-L-methionine-(S)-S-oxide + thioredoxin
N-acetyl-L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
oxidized calmodulin + thioredoxin
partially reduced calmodulin + thioredoxin disulfide
show the reaction diagram
-
enzyme reduces L-methionine (S)-sulfoxide of the protein substrate
-
-
?
peptide-L-methionine (S)-S-oxide + mycothiol
peptide-L-methionine + mycothione + H2O
show the reaction diagram
peptide-L-methionine (S)-S-oxide + thioredoxin
peptide-L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
peptide-L-methionine-(S)-S-oxide + DTT
peptide-L-methionine + DTT disulfide + H2O
show the reaction diagram
peptide-L-methionine-(S)-S-oxide + thioredoxin
peptide-L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
protein-L-methionine (S)-S-oxide + thioredoxin
protein-L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
Met sulfoxide residues in Met-rich proteins can be reduced by MsrA and MsrB
-
-
?
protein-L-methionine (S)-sulfoxide + thioredoxin
protein-L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
ribosomal protein L12-L-methionine (S)-sulfoxide + thioredoxin
ribosomal protein L12-L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
-
-
-
-
?
S-methyl p-tolyl sulfoxide + thioredoxin A
1-methyl-4-(methylsulfanyl)benzene + thioredoxin A disulfide + H2O
show the reaction diagram
-
-
-
?
S-methyl p-tolyl sulfoxide + thioredoxin C
1-methyl-4-(methylsulfanyl)benzene + thioredoxin C disulfide + H2O
show the reaction diagram
-
-
-
?
sulindac + thioredoxin
sulindac sulfide + thioredoxin disulfide
show the reaction diagram
sulindac + thioredoxin
sulindac sulfide + thioredoxin disulfide + H2O
show the reaction diagram
Tyr-Gly-Gly-Phe-L-methionine-(S)-S-oxide + DTT
Tyr-Gly-Gly-Phe-L-methionine + DTT disulfide + H2O
show the reaction diagram
Tyr-Gly-Gly-Phe-L-methionine-(S)-S-oxide + thioredoxin
Tyr-Gly-Gly-Phe-L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
additional information
?
-