1.8.4.12: peptide-methionine (R)-S-oxide reductase

This is an abbreviated version!
For detailed information about peptide-methionine (R)-S-oxide reductase, go to the full flat file.

Reaction

Synonyms

1-Cys methionine sulfoxide reductase B, 1-Cys MSRB, CBS-1, CBS1, cysteine-containing methionine-R-sulfoxide reductase, LOC100305558, LOC100798757, methionine sulfoxide reductase, methionine sulfoxide reductase B, methionine sulfoxide reductase B1, methionine sulfoxide reductase B2, methionine sulfoxide reductase B3, methionine sulfoxide reductase B8, methionine sulfoxide reductase MsrB3, methionine sulfoxide reductases B, methionine sulfoxide reductases B2, methionine sulphoxide reductase, methionine-R-sulfoxide reductase, methionine-R-sulfoxide reductase B, methionine-R-sulfoxide reductase B2, MetO reductase, More, MSR, MsrA, MsrA/B, MsrA/MsrB, msrAB, MsrABTk, MsrB, MSRB1, MsrB2, MsrB3, MsrB3A, MSRB4, MsrB5, MsrB7, MsrB8, MsrBA, Mxr2, NtMsrB2, OsMSRB5, PaMsrB1, peptide methionine sulfoxide reductase, peptide methionine sulfoxide reductase type B, PilB, PilB protein, PMSR, Sel-X, selenocysteine-containing methionine-R-sulfoxide reductase, selenoprotein R, SelR, sulindac reductase, TbmsrB, TCDM_06423, YeaA

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.4 With a disulfide as acceptor

                1.8.4.12 peptide-methionine (R)-S-oxide reductase

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Results	in table
8	Activating Compound
46160	AA Sequence
3	Application
69	Cloned(Commentary)
108	Cofactor
9	Crystallization (Commentary)
255	Disease/ Diagnostics
12	Expression
85	General Information
10	Inhibitors
34	kcat/KM [mM/s]
68	KM Value [mM]
100	Localization
45	Metals/Ions
22	Molecular Weight [Da]
140	Natural Substrates/ Products (Substrates)
378	Organism
2	Pathway
33	PDB ID
23	pH Optimum
1	pH Range
2	pI Value
85	Protein Variants
41	Purification (Commentary)
42	Reaction
262	Reference
141	Source Tissue
55	Specific Activity [micromol/min/mg]
1	Storage Stability
323	Substrates and Products (Substrate)
30	Subunits
417	Synonyms
1	Systematic Name
22	Temperature Optimum [°C]
2	Temperature Range [°C]
4	Temperature Stability [°C]
65	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 1.8.4.12 - peptide-methionine (R)-S-oxide reductase

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.005 - 3.4

dabsyl-L-methionine (R)-S-oxide

7 entries

1 - 3.1

dabsyl-L-methionine (R)-sulfoxide

6 entries

10

dithiothreitol

Solanum lycopersicum

-

recombinant enzyme, in 50 mM Tris-HCl, pH 8.0, at 37°C

726437

5.2

glutaredoxin

Leptospira interrogans

Q72NN2

30°C, pH 7.0, cosubstrate: N-acetyl-L-methionine-(R)-S-oxide

764237

73.4

glutaredoxin C4

Arabidopsis thaliana

-

isoform MSRB1 wild type enzyme

698915

-

0.09 - 1.4

L-methionine (R)-sulfoxide

2 entries

0.002 - 0.0076

L-methionine-(R)-S-oxide

2 entries

5 - 42

N-acetyl-L-methionine (R)-sulfoxide

2 entries

0.011 - 0.067

N-acetyl-L-methionine-(R)-S-oxide

5 entries

0.0008 - 1.03

thioredoxin

3 entries

0.024

trypanothione disulfide

Trypanosoma cruzi

V5BL87

pH 7.5, 30°C, cosubstrate: N-acetyl-L-methionine-(R)-S-oxide, mutant enzyme C72S/C74S

764710

0.417 - 2.778

tryparedoxin I

3 entries

-

0.005

dabsyl-L-methionine (R)-S-oxide

Treponema denticola

Q73PT7

isolated MrsB domain, pH 7.5, 37°C

741934

0.42

dabsyl-L-methionine (R)-S-oxide

Treponema denticola

Q73PT7

mutant Y163A//E165A, pH 7.5, 37°C

741934

0.72

dabsyl-L-methionine (R)-S-oxide

Treponema denticola

Q73PT7

mutant Y163A, pH 7.5, 37°C

741934

1.7

dabsyl-L-methionine (R)-S-oxide

Treponema denticola

Q73PT7

mutant E165A, pH 7.5, 37°C

741934

2.08

dabsyl-L-methionine (R)-S-oxide

Treponema denticola

Q73PT7

mutant D164A, pH 7.5, 37°C

741934

2.32

dabsyl-L-methionine (R)-S-oxide

Treponema denticola

Q73PT7

wild-type, pH 7.5, 37°C

741934

3.4

dabsyl-L-methionine (R)-S-oxide

Treponema denticola

Q73PT7

mutant C11S, pH 7.5, 37°C

741934

1

dabsyl-L-methionine (R)-sulfoxide

Helicobacter pylori

O25011

pH 7.5, 37°C, mutant enzyme E193A/D197A

763911

1.22

dabsyl-L-methionine (R)-sulfoxide

Helicobacter pylori

O25011

pH 7.5, 37°C, mutant enzyme D197A

763911

1.3

dabsyl-L-methionine (R)-sulfoxide

Helicobacter pylori

O25011

pH 7.5, 37°C, mutant enzyme E193A

763911

2.25

dabsyl-L-methionine (R)-sulfoxide

Helicobacter pylori

O25011

pH 7.5, 37°C, mutant enzyme E339A

763911

2.88

dabsyl-L-methionine (R)-sulfoxide

Helicobacter pylori

O25011

pH 7.5, 37°C, mutant enzyme Y343F

763911

3.1

dabsyl-L-methionine (R)-sulfoxide

Helicobacter pylori

O25011

pH 7.5, 37°C, wild-type enzyme

763911

0.09

L-methionine (R)-sulfoxide

Glycine max

-

isoform MSRB4, pH and temperature not specified in the publication

726340

1.4

L-methionine (R)-sulfoxide

Glycine max

-

isoform MSRB2, pH and temperature not specified in the publication

726340

0.002

L-methionine-(R)-S-oxide

Trypanosoma cruzi

V5BL87

pH 7.5, 30°C, cosubstrate: tryparedoxin I

764710

0.0076

L-methionine-(R)-S-oxide

Leptospira interrogans

Q72NN2

30°C, pH 7.0, cosubstrate: glutaredoxin

764237

5

N-acetyl-L-methionine (R)-sulfoxide

Glycine max

-

isoform MSRB4, pH and temperature not specified in the publication

726340

42

N-acetyl-L-methionine (R)-sulfoxide

Glycine max

-

isoform MSRB2, pH and temperature not specified in the publication

726340

0.011

N-acetyl-L-methionine-(R)-S-oxide

Trypanosoma cruzi

V5BL87

pH 7.5, 30°C, cosubstrate: tryparedoxin I, mutant enzyme C72S

764710

0.024

N-acetyl-L-methionine-(R)-S-oxide

Trypanosoma cruzi

V5BL87

pH 7.5, 30°C, cosubstrate: tryparedoxin I

764710

0.034

N-acetyl-L-methionine-(R)-S-oxide

Trypanosoma cruzi

V5BL87

pH 7.5, 30°C, cosubstrate: tryparedoxin I, mutant enzyme C74S

764710

0.054

N-acetyl-L-methionine-(R)-S-oxide

Trypanosoma cruzi

V5BL87

pH 7.5, 30°C, cosubstrate: trypanothione, mutant enzyme C72S/C74S

764710

0.067

N-acetyl-L-methionine-(R)-S-oxide

Leptospira interrogans

Q72NN2

30°C, pH 7.0, cosubstrate: glutaredoxin

764237

0.0008

thioredoxin

Nicotiana tabacum

-

pH 8.0, 37°C

743748

0.17

thioredoxin

Leptospira interrogans

Q72NN2

30°C, pH 7.0, cosubstrate: N-acetyl-L-methionine-(R)-S-oxide

764237

1.03

thioredoxin

Trypanosoma cruzi

V5BL87

pH 7.5, 30°C, cosubstrate: N-acetyl-L-methionine-(R)-S-oxide

764710

0.417

tryparedoxin I

Trypanosoma cruzi

V5BL87

pH 7.5, 30°C, cosubstrate: N-acetyl-L-methionine-(R)-S-oxide, mutant enzyme C72S

764710

-

1.307

tryparedoxin I

Trypanosoma cruzi

V5BL87

pH 7.5, 30°C, cosubstrate: N-acetyl-L-methionine-(R)-S-oxide, mutant enzyme C74S

764710

-

2.778

tryparedoxin I

Trypanosoma cruzi

V5BL87

pH 7.5, 30°C, cosubstrate: N-acetyl-L-methionine-(R)-S-oxide

764710

-