1.8.4.12: peptide-methionine (R)-S-oxide reductase
This is an abbreviated version!
For detailed information about peptide-methionine (R)-S-oxide reductase, go to the full flat file.
Word Map on EC 1.8.4.12
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1.8.4.12
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thioredoxins
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selenoproteins
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selenium
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msrbs
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neisseria
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metso
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trx
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sulfenic
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methionine-s-sulfoxide
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meningitidis
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thioredoxin-dependent
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selenoenzyme
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lincosamides
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synthesis
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biotechnology
- 1.8.4.12
- thioredoxins
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selenoproteins
- selenium
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msrbs
- neisseria
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metso
- trx
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sulfenic
- methionine-s-sulfoxide
- meningitidis
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thioredoxin-dependent
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selenoenzyme
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lincosamides
- synthesis
- biotechnology
Reaction
Synonyms
1-Cys methionine sulfoxide reductase B, 1-Cys MSRB, CBS-1, CBS1, cysteine-containing methionine-R-sulfoxide reductase, LOC100305558, LOC100798757, methionine sulfoxide reductase, methionine sulfoxide reductase B, methionine sulfoxide reductase B1, methionine sulfoxide reductase B2, methionine sulfoxide reductase B3, methionine sulfoxide reductase B8, methionine sulfoxide reductase MsrB3, methionine sulfoxide reductases B, methionine sulfoxide reductases B2, methionine sulphoxide reductase, methionine-R-sulfoxide reductase, methionine-R-sulfoxide reductase B, methionine-R-sulfoxide reductase B2, MetO reductase, More, MSR, MsrA, MsrA/B, MsrA/MsrB, msrAB, MsrABTk, MsrB, MSRB1, MsrB2, MsrB3, MsrB3A, MSRB4, MsrB5, MsrB7, MsrB8, MsrBA, Mxr2, NtMsrB2, OsMSRB5, PaMsrB1, peptide methionine sulfoxide reductase, peptide methionine sulfoxide reductase type B, PilB, PilB protein, PMSR, Sel-X, selenocysteine-containing methionine-R-sulfoxide reductase, selenoprotein R, SelR, sulindac reductase, TbmsrB, TCDM_06423, YeaA
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Source Tissue on EC 1.8.4.12 - peptide-methionine (R)-S-oxide reductase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
MsrB1 is highly expressed in HCC tissues and its expression correlates with the prognoses of patients with HCC after hepatectomy
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epithelia and fibers, isozymes MsrB1 or selenoprotein R, MsrB2 or CBS-1, and MsrB3, differential expression patterns of isozymes, overview
additional information
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enzyme form MsrB2 is detectable in the embryonic axes and in cotyledons
expression/activities of MSRA and MSRB are significantly decreased in the epidermis of patients with vitiligo compared to healthy controls
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cell line WI-38, young and old cells, enzyme expression pattern during cell development, senescent cells show decreased enzyme expression and activity
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marginal Zn deficiency has little effect on Msr in liver and kidney. Msr activity is significantly reduced by Se deficiency
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MsrB1 is present in the renal Mg2+-transporting distal convoluted tubules
expression levels are the highest in leaves, followed by roots, and lowest in seeds and seed pods. Among the MsrB isoforms, transcripts of MSRB1 in the leaves are the highest
expression levels are the highest in leaves, followed by roots, and lowest in seeds and seed pods. Among the MsrB isoforms, transcripts of MSRB5 in the leaves are the lowest
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marginal Zn deficiency has little effect on Msr in liver and kidney. Msr activity is significantly reduced by Se deficiency
control and stably overexpressing MsrA (from rat) and MsrB2 (from human). Zinc treatment has a pro-antioxidant effect in MOLT-4 cells by positively modulating the activity of the Msr enzymes. Overexpression of the Msr enzymes, due to their antioxidant properties, counteracts the pro-oxidant effects of zinc treatment, which lead to a cellular protection against protein oxidative damage and cell death, by reducing the production of reactive oxygen species
overexpression of human methionine sulfoxide reductase B2 in mitochondria of acute T-lymphoblastic leukemia MOLT-4 cell line, in which methionine sulfoxide reductase A is missing
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ethionine sulfoxide reductase B2 is highly expressed in the retina, in the monkey retina MSRB2 localizes to the ganglion cell layer, the outer plexiform layer and the retinal pigment epithelium
expression levels are the highest in leaves, followed by roots, and lowest in seeds and seed pods
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enzyme form MsrB2 is detectable in the embryonic axes and in cotyledons. A greater amount of MsrB2 is revealed in embryonic axes at the 14th weeks after flowering (WAF). The two redox MsrB2 forms (two different redox forms with molecular masses of 12000 Da and 13000 Da) are revealed in cotyledons at the 12th-16th WAF. During later stages, the 12000 Da form is hardly detectable in the cotyledons, and the protein abundance decreases. Higher abundance of reduced MsrB2 during the first stages of seed formation
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in embryonic axes, detectable amounts of the enzyme form MsrB1 are revealed at the 13th weeks after flowering (WAF). In cotyledons, MsrB1 is detectable one week earlier, and the protein is present in larger amounts throughout the whole development and during the maturation phase. Linear increase in the amount of the enzyme form MsrB1 at the 12th-17th WAF in cotyledons. Increased abundance of enzyme form MsrB1 at the 15th-17th WAF in embryonic axes. MsrB2 is detectable in the embryonic axes
the enzyme is detected in cortical cells and the outer area of the vascular cylinder of the embryonic axes as well as in the epidermis and parenchyma cells of cotyledons. The abundances of MsrB1 and MsrB2 decreased during long-term storage
expression levels are the highest in leaves, followed by roots, and lowest in seeds and seed pods
chronic sun-exposure would result in a decreased expression of two main components of the methionine sulfoxide reductase system, MsrA and MsrB2
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embryonic fibroblast, activity during development: downregulation during replicative senescence
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fibroblast, young and old cells, enzyme expression pattern during cell development
MsrB2 is downregulated during replicative senescence of WI-38 human fibroblasts
additional information
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high expression level of the plastidic isozyme pPMSR in photosynthetic active tissue
additional information
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enzyme expression level and methionine sulfoxide content in fibroblasts during development, overview
additional information
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tissue distribution, main expression of CBS1 in muscle tissues, overview
additional information
OsMSRB5 is mainly expressed in leaves, with low transcriptional levels of OsMSRB5 observed in seeds, stems, and roots
additional information
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presence of MsrABTk is greater in Thermococcus kodakaraensis cells grown at suboptimal temperatures (60 to 70°C) and could not be detected at 80 to 90°C. The amount of intracellular MsrABTk protein increases with exposure to higher dissolved oxygen levels, but only at suboptimal growth temperatures
