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1.8.4.13: L-methionine (S)-S-oxide reductase

This is an abbreviated version!
For detailed information about L-methionine (S)-S-oxide reductase, go to the full flat file.

Reaction

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L-methionine
+
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thioredoxin disulfide
+
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H2O
=
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L-methionine (S)-S-oxide
+
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thioredoxin

Synonyms

EC 1.8.4.5, free-methionine-R-sulfoxide reductase, fRMsr, fSMsr, methionine sulfoxide reductase

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.4 With a disulfide as acceptor
                EC 1.8.4.131.8.4.13 L-methionine (S)-S-oxide reductase

Substrates Products

Substrates Products on EC 1.8.4.13 - L-methionine (S)-S-oxide reductase

for references in articles please use BRENDA:EC1.8.4.13

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-(-)-methionine S-oxide + NADPH
L-methionine + NADP+ + H2O
show the reaction diagram
L-methionine (S)-S-oxide + NADPH
L-methionine + NADP+ + H2O
show the reaction diagram
L-methionine (S)-S-oxide + reduced DTT
L-methionine + oxidized DTT + H2O
show the reaction diagram
-
highest activity at 10 mM
-
-
?
L-methionine (S)-sulfoxide + NADPH + H+
L-methionine + NADP+ + H2O
show the reaction diagram
-
membrane-bound enzyme form Mem-R,S-Msr
-
-
?
L-methionine sulfoxide enkephalin + NADPH
L-methionine enkephalin + NADP+ + H2O
show the reaction diagram
-
membrane-bound enzyme form Mem-R,S-Msr
-
-
?
L-methionine-(S)-S-oxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
-
-
-
-
?
N-acetyl-L-methionine (S)-sulfoxide + thioredoxin
N-acetyl-L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
-
membrane-bound enzyme form Mem-R,S-Msr
-
-
?
sulindac + NADPH
sulindac sulfide + NADP+ + H2O
show the reaction diagram
additional information
?
-