1.8.4.2: protein-disulfide reductase (glutathione)

This is an abbreviated version!
For detailed information about protein-disulfide reductase (glutathione), go to the full flat file.

Reaction

2 glutathione +

Synonyms

BbdC, BdbD, C1orf31, CatA protein, ccdA associated thiol-disulfide oxidoreductase, COA6, DcbA, desulfothioredoxin, DIP1880, disulfide bond-forming thiol-disulfide oxidoreductase, disulphide interchange enzyme, DsbA, DsbA1, DsbA2, Dtrx, ERp57, GIT, glutathione-insulin transhydrogenase, glutathione-protein disulfide oxidoreductase, GRX1, GRX2, GRX3, GRX5, GRX6, GrxS12, GSH-dependent protein disulfide oxidoreductase, GSH-insulin transhydrogenase, HP_0231, insulin reductase, mcrophage migration inhibitory factor-2, MdbA, MdbACm, membrane-bound thiol-disulfide oxidoreductase, Mif-2, More, protein disulfide reductase (glutathione), protein disulfide transhydrogenase, protein-disulfide interchange enzyme, protein-disulfide isomerase/oxidoreductase, RCAP_rcc01743, reductase, protein disulfide (glutathione), ResA, SdbA, SGO_2006, SpyM18_2037, StoA, Streptococcus disulfide bond protein A, TDOR, thiol disulfide oxidoreductase, thiol-disulfide oxidoreductase, thiol-protein disulphide oxidoreductase, thiol:disulfide oxidoreductase, thiol:protein-disulfide oxidoreductase, WhiB1, WhiB1/Rv3219, YkuV, YMR244C-A

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.4 With a disulfide as acceptor

                1.8.4.2 protein-disulfide reductase (glutathione)

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Results	in table
32	Activating Compound
843	AA Sequence
1	Application
1	CAS Registry Number
23	Cloned(Commentary)
6	Crystallization (Commentary)
45	Disease/ Diagnostics
76	General Information
8	General Stability
101	Inhibitors
5	kcat/KM [mM/s]
2	Ki Value [mM]
51	KM Value [mM]
44	Localization
5	Metals/Ions
32	Molecular Weight [Da]
73	Natural Substrates/ Products (Substrates)
164	Organism
2	Pathway
31	PDB ID
14	pH Optimum
4	pH Range
5	Posttranslational Modification
47	Protein Variants
32	Purification (Commentary)
15	Reaction
3	Reaction Type
146	Reference
127	Source Tissue
38	Specific Activity [micromol/min/mg]
2	Storage Stability
313	Substrates and Products (Substrate)
30	Subunits
160	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
5	Temperature Stability [°C]
11	Turnover Number [1/s]

Organism

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Organism on EC 1.8.4.2 - protein-disulfide reductase (glutathione)

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Actinomyces oris

-

742796, 745224

A0A0M3KL32

UniProt

brenda

Aeropyrum pernix

-

726599

-

-

brenda

Aeropyrum pernix DSM 11879

-

726599

-

-

brenda

Bacillus subtilis

3 entries

Bos taurus

3 entries

Brassica napus

-

394856

-

-

brenda

Brevibacillus brevis

gene bdb

394859

-

-

brenda

Brevibacillus choshinensis

-

659538, 670810

-

-

brenda

Campylobacter jejuni subsp. jejuni

2 entries

Chlamydomonas reinhardtii

5 entries

Corynebacterium diphtheriae

-

743311

Q6NFK7

UniProt

brenda

Corynebacterium diphtheriae ATCC 700971

-

743311

Q6NFK7

UniProt

brenda

Corynebacterium matruchotii

-

765004

-

-

brenda

Corynebacterium matruchotii ATCC 14266

-

765004

-

-

brenda

Cricetulus griseus

chinese hamster

394854

-

-

brenda

Desulfovibrio vulgaris

-

725470

-

-

brenda

Dickeya chrysanthemi

DsbA homologous

394853

-

-

brenda

Dickeya chrysanthemi DsbA homologous

DsbA homologous

394853

-

-

brenda

Escherichia coli

5 entries

Haemophilus influenzae

2 entries

Haemophilus influenzae DsbA homologous

DsbA homologous

394853, 394855

-

-

brenda

Helicobacter pylori

-

742200

O25017

UniProt

brenda

Helicobacter pylori ATCC 700392

-

742200

O25017

UniProt

brenda

Homo sapiens

3 entries

Klebsiella sp.

DsbA homologous

394853

-

-

brenda

Klebsiella sp. DsbA homologous

DsbA homologous

394853

-

-

brenda

Legionella pneumophila

DsbA homologous

394853

P50024

SwissProt

brenda

Legionella pneumophila DsbA homologous

DsbA homologous

394853

P50024

SwissProt

brenda

Lelliottia amnigena

DsbA homologous

394853

Q9XDP0

SwissProt

brenda

Lelliottia amnigena DsbA homologous

DsbA homologous

394853

Q9XDP0

SwissProt

brenda

Mus musculus

-

394810, 394824, 394842, 394844

-

-

brenda

Mycobacterium tuberculosis

-

670797

-

-

brenda

Pectobacterium carotovorum

DsbA homologous

394853

-

-

brenda

Pectobacterium carotovorum DsbA homologous

DsbA homologous

394853

-

-

brenda

Populus sp.

-

762613

-

-

brenda

Pseudomonas aeruginosa

DsbA homologous

394853

P0C2B2

SwissProt

brenda

Pseudomonas aeruginosa DsbA homologous

DsbA homologous

394853

P0C2B2

SwissProt

brenda

Pseudomonas syringae

DsbA homologous

394853

O52376

GenBank

brenda

Pseudomonas syringae DsbA homologous

DsbA homologous

394853

O52376

GenBank

brenda

Rattus norvegicus

3 entries

Rhodobacter capsulatus

-

764747

D5AU49

UniProt

brenda

Rhodobacter capsulatus ATCC BAA-309

-

764747

D5AU49

UniProt

brenda

Rhodobacter capsulatus NBRC 16581

-

764747

D5AU49

UniProt

brenda

Rhodobacter capsulatus SB1003

-

764747

D5AU49

UniProt

brenda

Saccharomyces cerevisiae

-

764441

Q3E846

UniProt

brenda

Saccharomyces cerevisiae ATCC 204508

-

764441

Q3E846

UniProt

brenda

Salmonella enterica subsp. enterica serovar Enteritidis

DsbA homologous

394853

-

-

brenda

Salmonella enterica subsp. enterica serovar Enteritidis DsbA homologous

DsbA homologous

394853

-

-

brenda

Salmonella enterica subsp. enterica serovar Typhimurium

DsbA homologous

394853

-

-

brenda

Salmonella enterica subsp. enterica serovar Typhimurium DsbA homologous

DsbA homologous

394853

-

-

brenda

Shigella flexneri

DsbA homologous

394853

-

-

brenda

Shigella flexneri DsbA homologous

DsbA homologous

394853

-

-

brenda

Streptococcus gordonii

2 entries

Streptococcus gordonii ATCC 35105

-

765006

A8AZP5

UniProt

brenda

Streptococcus gordonii BCRC 15272

-

765006

A8AZP5

UniProt

brenda

Streptococcus gordonii CH1

-

765006

A8AZP5

UniProt

brenda

Streptococcus gordonii Challis

-

765006

A8AZP5

UniProt

brenda

Streptococcus gordonii DL1

-

765006

A8AZP5

UniProt

brenda

Streptococcus gordonii SecCR1

-

742794

-

-

brenda

Streptococcus gordonii V288

-

765006

A8AZP5

UniProt

brenda

Streptococcus pyogenes

-

765010

-

-

brenda

Triticum aestivum

-

686037

-

-

brenda

Vibrio cholerae serotype O1

2 entries

Vibrio cholerae serotype O1 DsbA homologous

DsbA homologous

394853, 394855

-

-

brenda

Wuchereria bancrofti

-

741551

A0A088FMA5

UniProt

brenda

Yersinia pestis

DsbA homologous

394853

-

-

brenda

Yersinia pestis DsbA homologous

DsbA homologous

394853

-

-

brenda

Bacillus subtilis

-

659011, 659051, 659204, 667560, 669523, 670699

-

-

brenda

Bacillus subtilis

gene bdbC and bdbD in BdbDC operon

394860, 394862

-

-

brenda

Bacillus subtilis

genes bdbA, bdbB in BdbAB operon

394862

-

-

brenda

Bos taurus

-

3051, 394810, 394811, 394817, 394819, 394825, 394826, 394827, 394828, 394829, 394831, 394833, 394834, 394835, 394836, 394837, 394838, 394839, 394845, 394847, 394848, 394849, 394851

-

-

brenda

Bos taurus

ox

3052, 394832

-

-

brenda

Bos taurus

steer

394840

-

-

brenda

Campylobacter jejuni subsp. jejuni

-

743646

-

-

brenda

Campylobacter jejuni subsp. jejuni

isoform DsbA2

743646

-

-

brenda

Chlamydomonas reinhardtii

isoform GRX1

763028, 763241

A8JHA9

UniProt

brenda

Chlamydomonas reinhardtii

isoform GRX2

763028

A8IYH1

UniProt

brenda

Chlamydomonas reinhardtii

isoform GRX3, CGFS type enzyme

763241

A8JH05

UniProt

brenda

Chlamydomonas reinhardtii

isoform GRX5

763028

A8I7Q4

UniProt

brenda

Chlamydomonas reinhardtii

isoform GRX6

763028

A8HN52

UniProt

brenda

Escherichia coli

-

394855, 394857, 659187

-

-

brenda

Escherichia coli

different forms of protein thiol:disulfide oxidoreductases with either oxidizing, gene DsbA, reducing, gene DsbB, or isomerising, gene DsbC and DsbD, activity exist in Escherichia coli

394853

-

-

brenda

Escherichia coli

DsbG gene

394861

-

-

brenda

Escherichia coli

in periplasm: DsbA and DsbB enzymes

394853

-

-

brenda

Escherichia coli

thiol-disulfide oxidoreductase like activity from gene DnaJ

394858

-

-

brenda

Haemophilus influenzae

DsbA homologous

394853, 394855

-

-

brenda

Haemophilus influenzae

Por gene

394855

-

-

brenda

Homo sapiens

-

394810, 394811, 394812, 394841, 394846, 394854, 659329

-

-

brenda

Homo sapiens

-

764441

Q5JTJ3

UniProt

brenda

Homo sapiens

macrophage migration inhibitory factor is a cytokine and pituitary hormone

394863

-

-

brenda

Rattus norvegicus

-

3067, 394810, 394811, 394812, 394813, 394814, 394815, 394816, 394817, 394818, 394820, 394821, 394823, 394830, 394832, 394843, 394847

-

-

brenda

Rattus norvegicus

sand rat, i.e. Psammomys obesus

394824

-

-

brenda

Rattus norvegicus

Wistar rat

394824

-

-

brenda

Streptococcus gordonii

-

725524, 742794

-

-

brenda

Streptococcus gordonii

-

765006

A8AZP5

UniProt

brenda

Vibrio cholerae serotype O1

DsbA homologous

394853, 394855

-

-

brenda

Vibrio cholerae serotype O1

tcpG gene

394855

-

-

brenda