1.8.4.8: phosphoadenylyl-sulfate reductase (thioredoxin)

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For detailed information about phosphoadenylyl-sulfate reductase (thioredoxin), go to the full flat file.

Word Map on EC 1.8.4.8

1.8.4.8

sulfurylase

assimilatory

sulfate-reducing

o-acetylserine

sulfonucleotide

sulfur-oxidizing

medicine

Reaction

Synonyms

3'-Phosphoadenosine 5'-phosphosulfate reductase, 3'-Phosphoadenylylsulfate reductase, 4Fe-4S adenylyl sulfate/phosphoadenylyl sulfate reductase, 5'-adenylylsulfate reductase, Adenosine 3'-phosphate 5'-phosphosulfate reductase, adenosine 5'-phosphosulfate reductase, Adenylyl phosphosulfate reductase, APR, APS reductase, CysH1, EC 1.8.99.4, PAdoPS reductase, PAPS reductase, PAPS reductase, thioredoxin dependent, PAPS reductase, thioredoxin-dependent, PAPS sulfotransferase, Phospho-adenylylsulfate (PAPS) reductase, Phospho-adenylylsulfate reductase, Reductase, 3'-phosphoadenosine 5'-phosphosulfate, SNR, Thioredoxin: 3'-phospho-adenylylsulfate reductase, Thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase

ECTree

1 Oxidoreductases

1.8 Acting on a sulfur group of donors

1.8.4 With a disulfide as acceptor

1.8.4.8 phosphoadenylyl-sulfate reductase (thioredoxin)

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Results	in table
2	Activating Compound
4752	AA Sequence
1	Application
1	CAS Registry Number
8	Cloned(Commentary)
9	Cofactor
3	Crystallization (Commentary)
1	General Stability
6	Inhibitors
2	kcat/KM [mM/s]
30	KM Value [mM]
3	Metals/Ions
4	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
35	Organism
1	Oxidation Stability
7	Pathway
23	PDB ID
3	pH Optimum
5	Protein Variants
7	Purification (Commentary)
5	Reaction
2	Reaction Type
17	Reference
4	Specific Activity [micromol/min/mg]
43	Substrates and Products (Substrate)
6	Subunits
34	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
9	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.8.4.8 - phosphoadenylyl-sulfate reductase (thioredoxin)

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adenosine 3',5'-bisphosphate

Escherichia coli

competitive with respect to 5-phosphoadenosine 3-phosphosulfate

133778

glutathione

Laccaria bicolor

0.002 to 0.6 mM

670348

N-(Iodoacetyl-aminoethyl)-5-N'-naphthylamin-1-sulfonic acid

N-bromosuccinimide

oxidized glutathione

reversible inhibition, forms mixed disulfides with the enzymes active site residue Cys239, inactivation kinetics, inhibition is reversible by glutaredoxin, not by DTT, glutaredoxin together with glutathione exhibits regulatory function in vivo

659214

p-chloromercuribenzoate

Escherichia coli

133778