1.8.5.3: respiratory dimethylsulfoxide reductase

This is an abbreviated version!
For detailed information about respiratory dimethylsulfoxide reductase, go to the full flat file.

Word Map on EC 1.8.5.3

Reaction

Dimethylsulfide
+
menaquinone
+
H2O
=
Dimethylsulfoxide
+
menaquinol

Synonyms

dimethyl sulfoxide/trimethylamine N-oxide reductase, dimethylsulfoxide reductase, DmsA, DmsABC, DmsC, DMSO reductase, DMSOR

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.5 With a quinone or similar compound as acceptor
                1.8.5.3 respiratory dimethylsulfoxide reductase

Cofactor

Cofactor on EC 1.8.5.3 - respiratory dimethylsulfoxide reductase

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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
bis(molybdopterin guanine dinucleotide)molybdenum cofactor
Fe-S center
molybdenum bis-molybdopterin guanine dinucleotide
molybdenum cofactor
-
residue W116 forms a hydrogen bond with a single oxo ligand bound to the molybdenum ion. Mutation of this residue to phenylalanine affects the UV/visible spectrum of the purified MoVI form of dimethylsulfoxide reductase resulting in the loss of the characteristic transition at 720 nm. W116 plays a critical role in stabilizing the hexacoordinate monooxo MoVI form of the enzyme and prevents the formation of a dioxo pentacoordinate MoVI species
molybdo-bis(pyranopterin guanine dinucleotide)
-
molybdopterin
-
molybdopterin guanine dinucleotide
-
-
[4Fe-4S]-center
role for the cluster in directing molybdenum cofactor assembly during enzyme maturation. The cluster is predicted to be in close proximity to the molybdo-bis(pyranopterin guanine dinucleotide) cofactor, which provides the site of dimethyl sulfoxide reduction