1.8.5.7: glutathionyl-hydroquinone reductase
This is an abbreviated version!
For detailed information about glutathionyl-hydroquinone reductase, go to the full flat file.
Reaction
Synonyms
ECM4, GHR1, glutathionyl-hydroquinone lyase, glutathionyl-hydroquinone reductase, nmagghr, Nmag_1170, NmGHR, pcpF, Xi class glutathione transferase, Xi class GST, yqjG
ECTree
1.8.5.7 glutathionyl-hydroquinone reductaseAdvanced search results
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Substrates Products on EC 1.8.5.7 - glutathionyl-hydroquinone reductase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-mercaptoethanol + 2-(glutathione-S-yl)-trichloro-p-hydroquinone
glutathionyl 2-mercaptoethanyl disulfide + trichloro-p-hydroquinone
-
-
-
-
?
dithiothreitol + 2-(glutathione-S-yl)-trichloro-p-hydroquinone
glutathionyl dithiothreityl disulfide + trichloro-p-hydroquinone
-
-
-
-
?
gamma-glutamylcysteine + 2-(glutathione-S-yl)-hydroquinone
gamma-glutamylcysteine glutahione disulfide + hydroquinone
gamma-glutamylcysteine + 2-(glutathione-S-yl)-hydroquinone
gamma-glutamylcysteine glutathione disulfide + hydroquinone
-
-
-
?
glutathione + (glutathione-S-yl)-2-chloro-1,4-benzoquinone
glutathione disulfide + 2-chloro-1,4-benzoquinone
-
-
-
-
?
glutathione + 2'-(glutathione-S-yl)-quercetin
glutathione disulfide + quercetin
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-1,4-benzoquinone
glutathione disulfide + 1,4-benzoquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
glutathione disulfide + hydroxy-p-hydroquinone
glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
glutathione disulfide + methyl-p-hydroquinone
glutathione + 2-(glutathione-S-yl)-quercetin
glutathione disulfide + quercetin
-
-
-
-
r
glutathione + 2-(glutathione-S-yl)-trichloro-p-hydroquinone
glutathione disulfide + trichloro-p-hydroquinone
glutathione + 3-(glutathione-S-yl)-2,6-dichloro-p-hydroquinone
glutathione disulfide + 2,6-dichloro-p-hydroquinone
L-cysteine + 2-(glutathione-S-yl)-trichloro-p-hydroquinone
glutathionyl cysteinyl disulfide + trichloro-p-hydroquinone
-
-
-
-
?
1,4-benzoquinone + 2-(glutathione-S-yl)-hydroquinone
?
-
-
-
?
1,4-benzoquinone + 2-(glutathione-S-yl)-hydroquinone
?
-
-
-
?
1,4-benzoquinone + 2-(glutathione-S-yl)-hydroquinone
?
-
-
-
?
1,4-benzoquinone + 2-(glutathione-S-yl)-hydroquinone
?
-
-
-
?
1,4-benzoquinone + 2-(glutathione-S-yl)-hydroquinone
?
-
-
-
?
1,4-benzoquinone + 2-(glutathione-S-yl)-hydroquinone
?
-
-
-
?
1,4-benzoquinone + 2-(glutathione-S-yl)-hydroquinone
?
-
-
-
?
1,4-benzoquinone + 2-(glutathione-S-yl)-hydroquinone
?
-
-
-
?
gamma-glutamylcysteine + 1-chloro-2,4-dinitrobenzene
?
-
-
-
?
gamma-glutamylcysteine + 1-chloro-2,4-dinitrobenzene
?
-
-
-
?
gamma-glutamylcysteine + 1-chloro-2,4-dinitrobenzene
?
-
-
-
?
gamma-glutamylcysteine + 1-chloro-2,4-dinitrobenzene
?
-
-
-
?
gamma-glutamylcysteine + 1-chloro-2,4-dinitrobenzene
?
-
-
-
?
gamma-glutamylcysteine + 1-chloro-2,4-dinitrobenzene
?
-
-
-
?
gamma-glutamylcysteine + 1-chloro-2,4-dinitrobenzene
?
-
-
-
?
gamma-glutamylcysteine + 1-chloro-2,4-dinitrobenzene
?
-
-
-
?
gamma-glutamylcysteine + 2-(glutathione-S-yl)-hydroquinone
gamma-glutamylcysteine glutahione disulfide + hydroquinone
-
-
-
?
gamma-glutamylcysteine + 2-(glutathione-S-yl)-hydroquinone
gamma-glutamylcysteine glutahione disulfide + hydroquinone
-
-
-
?
gamma-glutamylcysteine + 2-(glutathione-S-yl)-hydroquinone
gamma-glutamylcysteine glutahione disulfide + hydroquinone
-
-
-
?
gamma-glutamylcysteine + 2-(glutathione-S-yl)-hydroquinone
gamma-glutamylcysteine glutahione disulfide + hydroquinone
-
-
-
?
gamma-glutamylcysteine + 2-(glutathione-S-yl)-hydroquinone
gamma-glutamylcysteine glutahione disulfide + hydroquinone
-
-
-
?
gamma-glutamylcysteine + 2-(glutathione-S-yl)-hydroquinone
gamma-glutamylcysteine glutahione disulfide + hydroquinone
-
-
-
?
gamma-glutamylcysteine + 2-(glutathione-S-yl)-hydroquinone
gamma-glutamylcysteine glutahione disulfide + hydroquinone
-
-
-
?
gamma-glutamylcysteine + 2-(glutathione-S-yl)-hydroquinone
gamma-glutamylcysteine glutahione disulfide + hydroquinone
-
-
-
?
gamma-glutamylcysteine + 2-(glutathione-S-yl)-hydroquinone
gamma-glutamylcysteine glutahione disulfide + hydroquinone
-
-
-
?
gamma-glutamylcysteine + 2-(glutathione-S-yl)-hydroquinone
gamma-glutamylcysteine glutahione disulfide + hydroquinone
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
glutathione disulfide + hydroquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
glutathione disulfide + hydroquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
glutathione disulfide + hydroquinone
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
glutathione disulfide + hydroquinone
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
glutathione disulfide + hydroquinone
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
glutathione disulfide + hydroquinone
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
glutathione disulfide + hydroquinone
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
glutathione disulfide + hydroquinone
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
glutathione disulfide + hydroquinone
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
glutathione disulfide + hydroquinone
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
glutathione disulfide + hydroquinone
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
glutathione disulfide + hydroquinone
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
glutathione disulfide + hydroquinone
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
glutathione disulfide + hydroquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
glutathione disulfide + hydroquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
glutathione disulfide + hydroquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroquinone
glutathione disulfide + hydroquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
glutathione disulfide + hydroxy-p-hydroquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
glutathione disulfide + hydroxy-p-hydroquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
glutathione disulfide + hydroxy-p-hydroquinone
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
glutathione disulfide + hydroxy-p-hydroquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
glutathione disulfide + hydroxy-p-hydroquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-hydroxy-p-hydroquinone
glutathione disulfide + hydroxy-p-hydroquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-menadiol
glutathione disulfide + menadiol
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-menadiol
glutathione disulfide + menadiol
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-menadiol
glutathione disulfide + menadiol
-
-
-
?
glutathione + 2-(glutathione-S-yl)-menadiol
glutathione disulfide + menadiol
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-menadiol
glutathione disulfide + menadiol
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-menadiol
glutathione disulfide + menadione
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-menadiol
glutathione disulfide + menadione
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-menadione
glutathione disulfide + menadione
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-menadione
glutathione disulfide + menadione
-
-
-
?
glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
glutathione disulfide + methyl-p-hydroquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
glutathione disulfide + methyl-p-hydroquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
glutathione disulfide + methyl-p-hydroquinone
-
-
-
?
glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
glutathione disulfide + methyl-p-hydroquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
glutathione disulfide + methyl-p-hydroquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-methyl-p-hydroquinone
glutathione disulfide + methyl-p-hydroquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-trichloro-p-hydroquinone
glutathione disulfide + trichloro-p-hydroquinone
-
-
-
-
?
glutathione + 2-(glutathione-S-yl)-trichloro-p-hydroquinone
glutathione disulfide + trichloro-p-hydroquinone
-
-
-
-
?
glutathione + 3-(glutathione-S-yl)-2,6-dichloro-p-hydroquinone
glutathione disulfide + 2,6-dichloro-p-hydroquinone
-
-
-
-
?
glutathione + 3-(glutathione-S-yl)-2,6-dichloro-p-hydroquinone
glutathione disulfide + 2,6-dichloro-p-hydroquinone
-
-
-
-
?
additional information
?
-
-
several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred
-
-
?
additional information
?
-
-
several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred
-
-
?
additional information
?
-
several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred
-
-
?
additional information
?
-
the enzyme shows preference for gamma-glutamyl-cysteine over glutathione as a reducing thiol. The main activity of Xi class GSTs is thought to be the S-glutathionyl-hydroquinone thiol-dependent reduction, which is monitored using benzoquinone as a model substrate
-
-
-
additional information
?
-
-
the enzyme shows preference for gamma-glutamyl-cysteine over glutathione as a reducing thiol. The main activity of Xi class GSTs is thought to be the S-glutathionyl-hydroquinone thiol-dependent reduction, which is monitored using benzoquinone as a model substrate
-
-
-
additional information
?
-
the enzyme shows preference for gamma-glutamyl-cysteine over glutathione as a reducing thiol. The main activity of Xi class GSTs is thought to be the S-glutathionyl-hydroquinone thiol-dependent reduction, which is monitored using benzoquinone as a model substrate
-
-
-
additional information
?
-
the enzyme shows preference for gamma-glutamyl-cysteine over glutathione as a reducing thiol. The main activity of Xi class GSTs is thought to be the S-glutathionyl-hydroquinone thiol-dependent reduction, which is monitored using benzoquinone as a model substrate
-
-
-
additional information
?
-
the enzyme shows preference for gamma-glutamyl-cysteine over glutathione as a reducing thiol. The main activity of Xi class GSTs is thought to be the S-glutathionyl-hydroquinone thiol-dependent reduction, which is monitored using benzoquinone as a model substrate
-
-
-
additional information
?
-
the enzyme shows preference for gamma-glutamyl-cysteine over glutathione as a reducing thiol. The main activity of Xi class GSTs is thought to be the S-glutathionyl-hydroquinone thiol-dependent reduction, which is monitored using benzoquinone as a model substrate
-
-
-
additional information
?
-
the enzyme shows preference for gamma-glutamyl-cysteine over glutathione as a reducing thiol. The main activity of Xi class GSTs is thought to be the S-glutathionyl-hydroquinone thiol-dependent reduction, which is monitored using benzoquinone as a model substrate
-
-
-
additional information
?
-
the enzyme shows preference for gamma-glutamyl-cysteine over glutathione as a reducing thiol. The main activity of Xi class GSTs is thought to be the S-glutathionyl-hydroquinone thiol-dependent reduction, which is monitored using benzoquinone as a model substrate
-
-
-
additional information
?
-
the enzyme shows preference for gamma-glutamyl-cysteine over glutathione as a reducing thiol. The main activity of Xi class GSTs is thought to be the S-glutathionyl-hydroquinone thiol-dependent reduction, which is monitored using benzoquinone as a model substrate
-
-
-
additional information
?
-
the enzyme shows preference for gamma-glutamyl-cysteine over glutathione as a reducing thiol. The main activity of Xi class GSTs is thought to be the S-glutathionyl-hydroquinone thiol-dependent reduction, which is monitored using benzoquinone as a model substrate
-
-
-
additional information
?
-
the enzyme shows preference for gamma-glutamyl-cysteine over glutathione as a reducing thiol. The main activity of Xi class GSTs is thought to be the S-glutathionyl-hydroquinone thiol-dependent reduction, which is monitored using benzoquinone as a model substrate
-
-
-
additional information
?
-
-
isoform GHR1 catalyzes the deglutathionylation of both reduced and oxidized glutathionylated quinones, but the enzyme is more catalytically efficient with the reduced forms
-
-
?
additional information
?
-
-
several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred
-
-
?
additional information
?
-
-
PcpF catalyzes glutathione-dependent reduction of glutathionyl-trichloro-p-hydroquinone via a Ping Pong mechanism. First, PcpF reacts with glutathionyl-trichloro-p-hydroquinone to release trichloro-p-hydroquinone and forms a disulfide bond between its Cys53 residue and the glutathione moiety. Then, a glutathione comes in to regenerate PcpF and release glutathione disulfide
-
-
?
additional information
?
-
-
several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred
-
-
?
additional information
?
-
-
several benzoquinones spontaneously react with glutathione to form glutathionyl-hydroquinones via Michael addition. The enzyme reduces the glutathionyl-hydroquinones to the corresponding hydroquinones. The spontaneous and enzymatic reactions lead to the reduction of benzoquinones to hydroquinones with the concomitant oxidation of glutathione to glutathione disulfide. The enzyme does not use glutathionyl-benzoquinones or other thiol-hydroquinones, for example, S-cysteinylhydroquinone, as substrates. Hydrophobic, bulky substrates, such as glutathionyl-menadiol, are preferred
-
-
?
