1.8.5.8: eukaryotic sulfide quinone oxidoreductase

This is an abbreviated version!
For detailed information about eukaryotic sulfide quinone oxidoreductase, go to the full flat file.

Reaction

Synonyms

glutathione:CoQ reductase, HMT2, ScSQR, SQOR, SQR, Sqrdl, sulfide : quinone oxidoreductase, sulfide quinone oxidoreductase, sulfide:quinone oxidoreductase

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.5 With a quinone or similar compound as acceptor

                1.8.5.8 eukaryotic sulfide quinone oxidoreductase

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Results	in table
2	Activating Compound
11	AA Sequence
3	Application
6	Cloned(Commentary)
17	Cofactor
3	Crystallization (Commentary)
2	Expression
27	General Information
1	General Stability
5	IC50 Value
22	Inhibitors
15	kcat/KM [mM/s]
4	Ki Value [mM]
22	KM Value [mM]
17	Localization
13	Natural Substrates/ Products (Substrates)
19	Organism
4	Pathway
2	pH Optimum
1	pH Range
1	pI Value
2	Posttranslational Modification
2	Protein Variants
6	Purification (Commentary)
5	Reaction
19	Reference
18	Source Tissue
1	Specific Activity [micromol/min/mg]
44	Substrates and Products (Substrate)
6	Subunits
43	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
11	Turnover Number [1/s]

KM Value

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KM Value on EC 1.8.5.8 - eukaryotic sulfide quinone oxidoreductase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2 - 3

cysteine

Homo sapiens

Q9Y6N5

at pH 7.4 and 37°C

745313

0.008 - 22

glutathione

3 entries

22

homocysteine

Homo sapiens

Q9Y6N5

at pH 7.4 and 37°C

745313

0.00287 - 2

hydrogen sulfide

3 entries

0.005 - 0.35

Sulfide

8 entries

0.19 - 0.26

sulfite

3 entries

0.0156

ubiquinone

Urechis unicinctus

H2KXA2

at pH 8.5 and 37°C

745666

additional information

additional information

2 entries

-

0.008

glutathione

Homo sapiens

Q9Y6N5

enzyme in nanodiscs, at pH 6.8 and 25°C

742905

0.008

glutathione

Homo sapiens

Q9Y6N5

solubilized enzyme, at pH 6.8 and 25°C

742905

22

glutathione

Homo sapiens

Q9Y6N5

at pH 7.4 and 37°C

745313

0.00287

hydrogen sulfide

Rattus norvegicus

-

at pH 7.4 and 25°C

744869

0.00994

hydrogen sulfide

Arenicola marina

B0LD08

at pH 7.4 and 25°C

744869

2

hydrogen sulfide

Schizosaccharomyces pombe

-

at pH 7.8 and 25°C

745263

0.005

Sulfide

Homo sapiens

Q9Y6N5

with cysteine as acceptor, at pH 7.4 and 37°C

745313

0.007

Sulfide

Homo sapiens

Q9Y6N5

with homocysteine as acceptor, at pH 7.4 and 37°C

745313

0.01

Sulfide

Homo sapiens

Q9Y6N5

with glutathione as acceptor, at pH 7.4 and 37°C

745313

0.043

Sulfide

Urechis unicinctus

H2KXA2

with ubiquinone as cosubstrate, at pH 8.5 and 37°C

745666

0.13

Sulfide

Homo sapiens

Q9Y6N5

with sulfite as acceptor, at pH 7.4 and 37°C

745313

0.23

Sulfide

Homo sapiens

Q9Y6N5

enzyme in nanodiscs, at pH 6.8 and 25°C

742905

0.32

Sulfide

Homo sapiens

Q9Y6N5

at pH 7.4 and 37°C

745313

0.35

Sulfide

Homo sapiens

Q9Y6N5

solubilized enzyme, at pH 6.8 and 25°C

742905

0.19

sulfite

Homo sapiens

Q9Y6N5

solubilized enzyme, at pH 6.8 and 25°C

742905

0.22

sulfite

Homo sapiens

Q9Y6N5

at pH 7.4 and 37°C

745313

0.26

sulfite

Homo sapiens

Q9Y6N5

enzyme in nanodiscs, at pH 6.8 and 25°C

742905

additional information

additional information

Homo sapiens

Q9Y6N5

Michaelis-Menten analysis of SQR activity at varying CoA concentrations. Pre-steady state kinetic analysis of ndSQR-mediated sulfur transfer to CoA

764431

-

additional information

additional information

Homo sapiens

Q9Y6N5

substrate promiscuity and comparative kinetic analysis

764484

-