1.8.5.8: eukaryotic sulfide quinone oxidoreductase

This is an abbreviated version!
For detailed information about eukaryotic sulfide quinone oxidoreductase, go to the full flat file.

Reaction

Synonyms

glutathione:CoQ reductase, HMT2, ScSQR, SQOR, SQR, Sqrdl, sulfide : quinone oxidoreductase, sulfide quinone oxidoreductase, sulfide:quinone oxidoreductase

ECTree

1 Oxidoreductases

1.8 Acting on a sulfur group of donors

1.8.5 With a quinone or similar compound as acceptor

1.8.5.8 eukaryotic sulfide quinone oxidoreductase

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Results	in table
2	Activating Compound
11	AA Sequence
3	Application
6	Cloned(Commentary)
17	Cofactor
3	Crystallization (Commentary)
2	Expression
27	General Information
1	General Stability
5	IC50 Value
22	Inhibitors
15	kcat/KM [mM/s]
4	Ki Value [mM]
22	KM Value [mM]
17	Localization
13	Natural Substrates/ Products (Substrates)
19	Organism
4	Pathway
2	pH Optimum
1	pH Range
1	pI Value
2	Posttranslational Modification
2	Protein Variants
6	Purification (Commentary)
5	Reaction
19	Reference
18	Source Tissue
1	Specific Activity [micromol/min/mg]
44	Substrates and Products (Substrate)
6	Subunits
43	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
11	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.8.5.8 - eukaryotic sulfide quinone oxidoreductase

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hydrogen sulfide + glutathione + a quinone

S-sulfanylglutathione + a quinol

4 entries

hydrogen sulfide + glutathione + coenzyme Q

S-sulfanylglutathione + reduced coenzyme Q

2 entries

hydrogen sulfide + glutathione + quinone

S-sulfanylglutathione + quinol

4 entries

hydrogen sulfide + glutathione + ubiquinone

S-sulfanylglutathione + ubiquinol

Sinonovacula constricta

A0A6B9CM12

764525

additional information

Homo sapiens

Q9Y6N5

under physiological conditions, the primary sulfane sulfur acceptor for the SQOR reaction is GSH, generating glutathione persulfide (GSSH) as the product. Substrate promiscuity leads to dead-end complexes. Human SQOR exhibits remarkable substrate promiscuity, and in addition to sulfide, a number of nucleophiles can add to the resting trisulfide. The addition of alternative nucleophiles to resting SQOR leads to the corresponding 379Cys mixed disulfide and the 201Cys-SS- persulfide that forms an intense charge transfer (CT) complex with FAD. Unlike the sulfide-induced CT complex, which decays quickly to yield FADH2, the alternative CT complexes represent dead-end complexes and decay slowly at rates that approximate the respective dissociation rate constants (koff) for the nucleophiles. Although these dead-end complexes could entrap SQOR in an unproductive state, their formation is suppressed to some extent by the membrane environment of SQOR

764484