1.8.7.3: ferredoxin:CoB-CoM heterodisulfide reductase

This is an abbreviated version!
For detailed information about ferredoxin:CoB-CoM heterodisulfide reductase, go to the full flat file.

Reaction

2 oxidized ferredoxin [iron-sulfur] cluster +

= 2 reduced ferredoxin [iron-sulfur] cluster +

+ 2 H+

Synonyms

CoB-CoM heterodisulfide reductase, CoB-CoM heterodisulfide reductase iron-sulfur subunit A, CoB-S-S-CoM reductase, Coenzyme B-Coenzyme M heterodisulfide reductase, ferredoxin:heterodisulfide oxidoreductase, HDR, hdrA1B1C1, hdrA2B2C2, HdrABC, HdrB, HdrB2, HdrB2C2, HdrD, heterodisulfide reductase, Mhun_1838, More

ECTree

1 Oxidoreductases

1.8 Acting on a sulfur group of donors

1.8.7 With an iron-sulfur protein as acceptor

1.8.7.3 ferredoxin:CoB-CoM heterodisulfide reductase

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Results	in table
48	AA Sequence
9	Application
2	Cloned(Commentary)
20	Cofactor
4	Crystallization (Commentary)
1	Expression
53	General Information
5	KM Value [mM]
13	Localization
7	Metals/Ions
29	Natural Substrates/ Products (Substrates)
26	Organism
4	Pathway
4	Purification (Commentary)
12	Reaction
24	Reference
34	Substrates and Products (Substrate)
14	Subunits
66	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.8.7.3 - ferredoxin:CoB-CoM heterodisulfide reductase

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CoB,CoM:ferredoxin oxidoreductase

HdrABC is an enzyme complex that is found in most methanogens and catalyses the reduction of the CoB-CoM heterodisulfide back to CoB and CoM. HdrA contains a FAD cofactor that acts as the entry point for electrons, which are transferred via HdrC to the HdrB catalytic subunit. One form of the enzyme from Methanosarcina acetivorans (HdrA2B2C2) can also catalyse EC 1.8.98.4, coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase. cf. EC 1.8.98.5, H2:CoB-CoM heterodisulfide,ferredoxin reductase, EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase, and EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase.