1.8.98.2: sulfiredoxin

This is an abbreviated version!
For detailed information about sulfiredoxin, go to the full flat file.

Word Map on EC 1.8.98.2

Reaction

peroxiredoxin-(S-hydroxy-S-oxocysteine)
+
ATP
+ 2 R-SH =
peroxiredoxin-(S-hydroxycysteine)
+
ADP
+
phosphate
+
R-S-S-R

Synonyms

AtSrx, cysteine-sulfinic acid reductase, neoplastic progression 3, peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase, protein cysteine sulfinic acid reductase, Srx, Srx1, Srxn1, sulfiredoxin, sulfiredoxin 1, sulfiredoxin-1, sulphiredoxin

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.98 With other, known, physiological acceptors
                1.8.98.2 sulfiredoxin

Expression

Expression on EC 1.8.98.2 - sulfiredoxin

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
adrenocortical tumor cell lines show increased enzyme expression. Adrenocorticotropic hormone also induces upregulation of the enzyme with its levels peaking at 3-6 h after injection of adrenocorticotropic hormone
-
disruption of Nrf2 signaling down-regulates the expression of Srx1
high glucose induces enzyme expression
-
Nrf2, nuclear factor erythroid-2-related factor, up-regulates Srx1 expression during oxidative stress caused by cigarette smoke exposure in the lungs
oxidative stress and growth factors can markedly upregulate Srx transcript and protein levels
-