1.8.98.5: H2:CoB-CoM heterodisulfide,ferredoxin reductase
This is an abbreviated version!
For detailed information about H2:CoB-CoM heterodisulfide,ferredoxin reductase, go to the full flat file.
Word Map on EC 1.8.98.5
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1.8.98.5
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methanococcus
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methanogenic
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hydrogenases
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archaea
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nickel
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epr
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voltae
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sulfur
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methanosarcina
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energy-conserving
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ni
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hyperfine
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methanobacterium
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selenocysteine
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f420-reducing
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fad
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heterolytic
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methane
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selenium-containing
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barkeri
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illumination
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selenium
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thermoautotrophicum
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com-s-s-cob
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methanothermobacter
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hydrogenotrophic
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non-heme
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marburgensis
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acid-labile
- 1.8.98.5
- methanococcus
-
methanogenic
- hydrogenases
- archaea
- nickel
- epr
- voltae
- sulfur
- methanosarcina
-
energy-conserving
- ni
-
hyperfine
-
methanobacterium
- selenocysteine
-
f420-reducing
- fad
-
heterolytic
- methane
-
selenium-containing
- barkeri
- illumination
- selenium
- thermoautotrophicum
- com-s-s-cob
-
methanothermobacter
-
hydrogenotrophic
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non-heme
- marburgensis
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acid-labile
Reaction
2 reduced ferredoxin [iron-sulfur] cluster + + + 2 H+ = 2 H2 + 2 oxidized ferredoxin [iron-sulfur] cluster +
Synonyms
CoB-CoM heterodisulfide reductase, F420-non-reducing hydrogenase, H2-driven FBEB, H2: CoM-S-S-CoB oxidoreductase, H2: heterodisulfide oxidoreductase complex, HdrA, hdrA1B1C1, HdrABC, HdrABC-MvhAGD, HdrB, HdrC, HdrDE, HdrDE-VhoGAC, heterodisulfide reductase, heterodisulfide reductase complex, hydrogenase, More, Mvh, MvhA, MvhADG, MvhADG/HdrABC, MvhD, MvhG, VhoGAC, Vhu
ECTree
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Subunits
Subunits on EC 1.8.98.5 - H2:CoB-CoM heterodisulfide,ferredoxin reductase
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heterododecamer
(MvhAGD-HdrABC)2 , 1 * 72000, HdrA, + 1 * 33000, HdrB, + 1 * 21000, HdrC, + 1 * 53000, MvhA, + 1 * 34000, MvhG, + 1 * 16000, MvhD, SDS-PAGE
heterohexamer
additional information
Methanobacterium thermoautotrophicus
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2 * 80000 + 2 * 51000 + 2 * 41000 + 2 * 36000 + 2 * 21000 + 2 * 17000, SDS-PAGE
heterohexamer
Methanobacterium thermoautotrophicus DSM 2133
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2 * 80000 + 2 * 51000 + 2 * 41000 + 2 * 36000 + 2 * 21000 + 2 * 17000, SDS-PAGE
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three Hdr complexes employing two Vhu domains [(Vhu)2Hdr complex], two Fdh domains [(Fdh)2Hdr complex], or one Vhu and one Fdh domain forming a heterocomplex (Fdh/Vhu/Hdr complex)
additional information
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three Hdr complexes employing two Vhu domains [(Vhu)2Hdr complex], two Fdh domains [(Fdh)2Hdr complex], or one Vhu and one Fdh domain forming a heterocomplex (Fdh/Vhu/Hdr complex)
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additional information
domain structure of the HdrA dimer and MvhD, overview. Soluble HDR is composed of the three subunits HdrA, HdrB, and HdrC and is associated to a [NiFe] hydrogenase built up of three subunits termed MvhA, MvhG, and MvhD. Each HdrA consists of a central TrxR domain, the N-terminal domain, the C-terminal domain, and the Fd domain. HdrA is the catalytic subunit. Standard HdrC-like components consist of a Fd-like domain. It can be regarded as a linker module that electronically wires HdrA to HdrB by its two [4Fe-4S] clusters. HdrB-like components contain a conserved cysteine-rich motif, referred to as CCG domain that is involved in binding two unique non-cubane [4Fe-4S] clusters. They are directly involved in heterodisulfide reduction in the active site of HDRs. The MvhD component was originally referred to as subunit of the hydrogenase component (Mvh, methyl viologen-dependent hydrogenase) in the archetypical MvhAGD-HdrABC complex
additional information
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domain structure of the HdrA dimer and MvhD, overview. Soluble HDR is composed of the three subunits HdrA, HdrB, and HdrC and is associated to a [NiFe] hydrogenase built up of three subunits termed MvhA, MvhG, and MvhD. Each HdrA consists of a central TrxR domain, the N-terminal domain, the C-terminal domain, and the Fd domain. HdrA is the catalytic subunit. Standard HdrC-like components consist of a Fd-like domain. It can be regarded as a linker module that electronically wires HdrA to HdrB by its two [4Fe-4S] clusters. HdrB-like components contain a conserved cysteine-rich motif, referred to as CCG domain that is involved in binding two unique non-cubane [4Fe-4S] clusters. They are directly involved in heterodisulfide reduction in the active site of HDRs. The MvhD component was originally referred to as subunit of the hydrogenase component (Mvh, methyl viologen-dependent hydrogenase) in the archetypical MvhAGD-HdrABC complex
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additional information
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domain structure of the HdrA dimer and MvhD, overview. Soluble HDR is composed of the three subunits HdrA, HdrB, and HdrC and is associated to a [NiFe] hydrogenase built up of three subunits termed MvhA, MvhG, and MvhD. Each HdrA consists of a central TrxR domain, the N-terminal domain, the C-terminal domain, and the Fd domain. HdrA is the catalytic subunit. Standard HdrC-like components consist of a Fd-like domain. It can be regarded as a linker module that electronically wires HdrA to HdrB by its two [4Fe-4S] clusters. HdrB-like components contain a conserved cysteine-rich motif, referred to as CCG domain that is involved in binding two unique non-cubane [4Fe-4S] clusters. They are directly involved in heterodisulfide reduction in the active site of HDRs. The MvhD component was originally referred to as subunit of the hydrogenase component (Mvh, methyl viologen-dependent hydrogenase) in the archetypical MvhAGD-HdrABC complex
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additional information
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domain structure of the HdrA dimer and MvhD, overview. Soluble HDR is composed of the three subunits HdrA, HdrB, and HdrC and is associated to a [NiFe] hydrogenase built up of three subunits termed MvhA, MvhG, and MvhD. Each HdrA consists of a central TrxR domain, the N-terminal domain, the C-terminal domain, and the Fd domain. HdrA is the catalytic subunit. Standard HdrC-like components consist of a Fd-like domain. It can be regarded as a linker module that electronically wires HdrA to HdrB by its two [4Fe-4S] clusters. HdrB-like components contain a conserved cysteine-rich motif, referred to as CCG domain that is involved in binding two unique non-cubane [4Fe-4S] clusters. They are directly involved in heterodisulfide reduction in the active site of HDRs. The MvhD component was originally referred to as subunit of the hydrogenase component (Mvh, methyl viologen-dependent hydrogenase) in the archetypical MvhAGD-HdrABC complex
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additional information
-
domain structure of the HdrA dimer and MvhD, overview. Soluble HDR is composed of the three subunits HdrA, HdrB, and HdrC and is associated to a [NiFe] hydrogenase built up of three subunits termed MvhA, MvhG, and MvhD. Each HdrA consists of a central TrxR domain, the N-terminal domain, the C-terminal domain, and the Fd domain. HdrA is the catalytic subunit. Standard HdrC-like components consist of a Fd-like domain. It can be regarded as a linker module that electronically wires HdrA to HdrB by its two [4Fe-4S] clusters. HdrB-like components contain a conserved cysteine-rich motif, referred to as CCG domain that is involved in binding two unique non-cubane [4Fe-4S] clusters. They are directly involved in heterodisulfide reduction in the active site of HDRs. The MvhD component was originally referred to as subunit of the hydrogenase component (Mvh, methyl viologen-dependent hydrogenase) in the archetypical MvhAGD-HdrABC complex
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additional information
-
domain structure of the HdrA dimer and MvhD, overview. Soluble HDR is composed of the three subunits HdrA, HdrB, and HdrC and is associated to a [NiFe] hydrogenase built up of three subunits termed MvhA, MvhG, and MvhD. Each HdrA consists of a central TrxR domain, the N-terminal domain, the C-terminal domain, and the Fd domain. HdrA is the catalytic subunit. Standard HdrC-like components consist of a Fd-like domain. It can be regarded as a linker module that electronically wires HdrA to HdrB by its two [4Fe-4S] clusters. HdrB-like components contain a conserved cysteine-rich motif, referred to as CCG domain that is involved in binding two unique non-cubane [4Fe-4S] clusters. They are directly involved in heterodisulfide reduction in the active site of HDRs. The MvhD component was originally referred to as subunit of the hydrogenase component (Mvh, methyl viologen-dependent hydrogenase) in the archetypical MvhAGD-HdrABC complex
-
additional information
-
domain structure of the HdrA dimer and MvhD, overview. Soluble HDR is composed of the three subunits HdrA, HdrB, and HdrC and is associated to a [NiFe] hydrogenase built up of three subunits termed MvhA, MvhG, and MvhD. Each HdrA consists of a central TrxR domain, the N-terminal domain, the C-terminal domain, and the Fd domain. HdrA is the catalytic subunit. Standard HdrC-like components consist of a Fd-like domain. It can be regarded as a linker module that electronically wires HdrA to HdrB by its two [4Fe-4S] clusters. HdrB-like components contain a conserved cysteine-rich motif, referred to as CCG domain that is involved in binding two unique non-cubane [4Fe-4S] clusters. They are directly involved in heterodisulfide reduction in the active site of HDRs. The MvhD component was originally referred to as subunit of the hydrogenase component (Mvh, methyl viologen-dependent hydrogenase) in the archetypical MvhAGD-HdrABC complex
-
additional information
-
domain structure of the HdrA dimer and MvhD, overview. Soluble HDR is composed of the three subunits HdrA, HdrB, and HdrC and is associated to a [NiFe] hydrogenase built up of three subunits termed MvhA, MvhG, and MvhD. Each HdrA consists of a central TrxR domain, the N-terminal domain, the C-terminal domain, and the Fd domain. HdrA is the catalytic subunit. Standard HdrC-like components consist of a Fd-like domain. It can be regarded as a linker module that electronically wires HdrA to HdrB by its two [4Fe-4S] clusters. HdrB-like components contain a conserved cysteine-rich motif, referred to as CCG domain that is involved in binding two unique non-cubane [4Fe-4S] clusters. They are directly involved in heterodisulfide reduction in the active site of HDRs. The MvhD component was originally referred to as subunit of the hydrogenase component (Mvh, methyl viologen-dependent hydrogenase) in the archetypical MvhAGD-HdrABC complex
additional information
domain structure of the HdrA dimer and MvhD, overview. Soluble HDR is composed of the three subunits HdrA (72 kDa), HdrB (33 kDa) and HdrC (21 kDa) and is associated to a [NiFe] hydrogenase built up of three subunits termed MvhA (53 kDa), MvhG (34 kDa) and MvhD (16 kDa). Each HdrA consists of a central TrxR domain, the N-terminal domain, the C-terminal domain, and the Fd domain. HdrA is the catalytic subunit. Standard HdrC-like components consist of a Fd-like domain. It can be regarded as a linker module that electronically wires HdrA to HdrB by its two [4Fe-4S] clusters. HdrB-like components contain a conserved cysteine-rich motif, referred to as CCG domain that is involved in binding two unique non-cubane [4Fe-4S] clusters. They are directly involved in heterodisulfide reduction in the active site of HDRs. The MvhD component was originally referred to as subunit of the hydrogenase component (Mvh, methyl viologen-dependent hydrogenase) in the archetypical MvhAGD-HdrABC complex