dissimilatory sulfite reductase

This is an abbreviated version!
For detailed information about dissimilatory sulfite reductase, go to the full flat file.

Word Map on EC


a [DsrC protein]-S-sulfanyl-L-cysteine
+ 2 acceptor + 3 H2O =
a [DsrC protein]-dithiol
+ 2 reduced acceptor + 2 H+


dSiR, DsrA, DsrAB, DsrC, DsvA, DsvB, hydrogen-sulfide:(acceptor) oxidoreductase, octahaemcytochrome c MccA, PAE2566, SiRA, siroheme sulfite reductase, sulfite reductase


     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.99 With unknown physiological acceptors
       dissimilatory sulfite reductase

Systematic Name

Systematic Name on EC - dissimilatory sulfite reductase

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IUBMB Comments
hydrogen-sulfide:[DsrC sulfur-carrier protein],acceptor oxidoreductase
Contain siroheme. The enzyme is essential in prokaryotic sulfur-based energy metabolism, including sulfate/sulfite reducing organisms, sulfur-oxidizing bacteria, and organosulfonate reducers. In sulfur reducers it catalyses the reduction of sulfite to sulfide (reaction 1 in the right to left direction), while in sulfur oxidizers it catalyses the opposite reaction (reaction 2 in the left to right direction) [1]. The reaction involves the small protein DsrC, which is present in all the organisms that contain dissimilatory sulfite reductase. During the process an intramolecular disulfide bond is formed between two L-cysteine residues of DsrC. This disulfide can be reduced by a number of proteins including DsrK and TcmB [5]. This enzyme is different from EC, assimilatory sulfite reductase (NADPH), and EC, assimilatory sulfite reductase (ferredoxin), which are involved in sulfate assimilation.