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EC 1.1.1.307 Details
EC number
1.1.1.307
Accepted name
D-xylose reductase [NAD(P)H]
Reaction
xylitol + NAD(P)+ = D-xylose + NAD(P)H + H+
Other name(s)
XylR, msXR, dsXR, dual specific xylose reductase, NAD(P)H-dependent xylose reductase, xylose reductase (ambiguous), D-xylose reductase (ambiguous)
Systematic name
xylitol:NAD(P)+ oxidoreductase
Comment
Xylose reductases catalyse the reduction of xylose to xylitol, the initial reaction in the fungal D-xylose degradation pathway. Most of the enzymes exhibit a strict requirement for NADPH [cf. EC 1.1.1.431, D-xylose reductase (NADPH)]. However, a few D-xylose reductases, such as those from Neurospora crassa [5], Yamadazyma tenuis [2,3], Scheffersomyces stipitis [1], and the thermophilic fungus Chaetomium thermophilum [4,7], have dual coenzyme specificity, though they still prefer NADPH to NADH. Very rarely the enzyme prefers NADH [cf. EC 1.1.1.430, D-xylose reductase (NADH)].
History
created 2010, modified 2022
EC Tree
2.5.1.12 created 1972, deleted 1976
2.5.1.13 created 1972, deleted 1976
2.5.1.14 created 1972, deleted 1976
2.5.1.37 created 1989, deleted 2004
2.5.1.40 created 1992, deleted 1999