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EC 2.1.1.264 Details
EC number
2.1.1.264
Accepted name
23S rRNA (guanine2069-N7)-methyltransferase
Reaction
S-adenosyl-L-methionine + guanine2069 in 23S rRNA = S-adenosyl-L-homocysteine + N7-methylguanine2069 in 23S rRNA
Other name(s)
rlmK (gene name), 23S rRNA m7G2069 methyltransferase
Systematic name
S-adenosyl-L-methionine:23S rRNA (guanine2069-N7)-methyltransferase
Comment
The enzyme specifically methylates guanine2069 at position N7 in 23S rRNA. In γ-proteobacteria the enzyme also catalyses EC 2.1.1.173, 23S rRNA (guanine2445-N2)-methyltransferase, while in β-proteobacteria the activities are carried out by separate proteins [1]. The enzyme from the γ-proteobacterium Escherichia coli has RNA unwinding activity as well [1].
History
created 2012
EC Tree
2.5.1.12 created 1972, deleted 1976
2.5.1.13 created 1972, deleted 1976
2.5.1.14 created 1972, deleted 1976
2.5.1.37 created 1989, deleted 2004
2.5.1.40 created 1992, deleted 1999