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EC Explorer

EC 7.6.2.8 Details
EC number
7.6.2.8
Accepted name
ABC-type vitamin B12 transporter
Reaction
ATP + H2O + vitamin B12-[cobalamin-binding protein][side 1] = ADP + phosphate + vitamin B12[side 2] + [cobalamin-binding protein][side 1]
Other name(s)
BtuCDF, vitamin B12 ABC transporter, vitamin B12-transporting ATPase
Systematic name
ATP phosphohydrolase (ABC-type, vitamin B12-importing)
Comment
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of cobalamin derivatives.
History
created 2000 as EC 3.6.3.33, transferred 2018 to EC 7.6.2.8
EC Tree
2.5.1.12 created 1972, deleted 1976
2.5.1.13 created 1972, deleted 1976
2.5.1.14 created 1972, deleted 1976
2.5.1.37 created 1989, deleted 2004
2.5.1.40 created 1992, deleted 1999