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EC 3.4.22.63 Details
EC number
3.4.22.63
Accepted name
caspase-10
Reaction
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp┼Gly
Other name(s)
FLICE2, Mch4, CASP-10, ICE-like apoptotic protease 4, apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1β-converting enzyme 2
CAS registry number
189088-85-5
Comment
Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62) [1]. Like caspase-8, caspase-10 contains two tandem death effector domains (DEDs) in its N-terminal prodomain, and these play a role in procaspase activation [1]. The enzyme has many overlapping substrates in common with caspase-8, such as RIP (the cleavage of which impairs NF-κB survival signalling and starts the cell-death process) and PAK2 (associated with some of the morphological features of apoptosis, such as cell rounding and apoptotic body formation) [2]. Bid, a Bcl2 protein, can be cleaved by caspase-3 (EC 3.4.22.56), caspase-8 and caspase-10 at Lys-Gln-Thr-Asp┼ to yield the pro-apoptotic p15 fragment. The p15 fragment is N-myristoylated and enhances the release of cytochrome c from mitochondria (which, in turn, initiatiates the intrinsic apoptosis pathway). Bid can be further cleaved by caspase-10 and granzyme B but not by caspase-3 or caspase-8 at Ile-Glu-Thr-Asp┼ to yield a p13 fragment that is not N-myristoylated [2]. Belongs in peptidase family C14.
History
created 2007
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EC Tree
1 Oxidoreductases
2 Transferases
2.1 Transferring one-carbon groups
2.2 Transferring aldehyde or ketonic groups
2.3 Acyltransferases
2.4 Glycosyltransferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
2.5.1.1 dimethylallyltranstransferase
2.5.1.2 thiamine pyridinylase
2.5.1.3 thiamine phosphate synthase
2.5.1.4 adenosylmethionine cyclotransferase
2.5.1.5 galactose-6-sulfurylase
2.5.1.6 methionine adenosyltransferase
2.5.1.7 UDP-N-acetylglucosamine 1-carboxyvinyltransferase
2.5.1.8 tRNA isopentenyltransferase
2.5.1.9 riboflavin synthase
2.5.1.10 (2E,6E)-farnesyl diphosphate synthase
2.5.1.11 trans-octaprenyltranstransferase
2.5.1.12 created 1972, deleted 1976
2.5.1.13 created 1972, deleted 1976
2.5.1.14 created 1972, deleted 1976
2.5.1.15 dihydropteroate synthase
2.5.1.16 spermidine synthase
2.5.1.17 corrinoid adenosyltransferase
2.5.1.18 glutathione transferase
2.5.1.19 3-phosphoshikimate 1-carboxyvinyltransferase
2.5.1.20 rubber cis-polyprenylcistransferase
2.5.1.21 squalene synthase
2.5.1.22 spermine synthase
2.5.1.23 sym-norspermidine synthase
2.5.1.24 discadenine synthase
2.5.1.25 tRNA-uridine aminocarboxypropyltransferase
2.5.1.26 alkylglycerone-phosphate synthase
2.5.1.27 adenylate dimethylallyltransferase (AMP-dependent)
2.5.1.28 dimethylallylcistransferase
2.5.1.29 geranylgeranyl diphosphate synthase
2.5.1.30 heptaprenyl diphosphate synthase
2.5.1.31 ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
2.5.1.32 15-cis-phytoene synthase
2.5.1.33 trans-pentaprenyltranstransferase
2.5.1.34 4-dimethylallyltryptophan synthase
2.5.1.35 aspulvinone dimethylallyltransferase
2.5.1.36 trihydroxypterocarpan dimethylallyltransferase
2.5.1.37 created 1989, deleted 2004
2.5.1.38 isonocardicin synthase
2.5.1.39 4-hydroxybenzoate polyprenyltransferase
2.5.1.40 created 1992, deleted 1999
2.5.1.41 phosphoglycerol geranylgeranyltransferase
2.5.1.42 geranylgeranylglycerol-phosphate geranylgeranyltransferase
2.5.1.43 nicotianamine synthase
2.5.1.44 homospermidine synthase
2.5.1.45 homospermidine synthase (spermidine-specific)
2.5.1.46 deoxyhypusine synthase
2.5.1.47 cysteine synthase
2.5.1.48 cystathionine γ-synthase
2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferase
2.5.1.50 zeatin 9-aminocarboxyethyltransferase
2.5.1.51 β-pyrazolylalanine synthase
2.5.1.52 L-mimosine synthase
2.5.1.53 uracilylalanine synthase
2.5.1.54 3-deoxy-7-phosphoheptulonate synthase
2.5.1.55 3-deoxy-8-phosphooctulonate synthase
2.5.1.56 N-acetylneuraminate synthase
2.5.1.57 N-acylneuraminate-9-phosphate synthase
2.5.1.58 protein farnesyltransferase
2.5.1.59 protein geranylgeranyltransferase type I
2.5.1.60 protein geranylgeranyltransferase type II
2.5.1.61 hydroxymethylbilane synthase
2.5.1.62 chlorophyll synthase
2.5.1.63 adenosyl-fluoride synthase
2.5.1.64 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
2.5.1.65 O-phosphoserine sulfhydrylase
2.5.1.66 N2-(2-carboxyethyl)arginine synthase
2.5.1.67 chrysanthemyl diphosphate synthase
2.5.1.68 (2Z,6E)-farnesyl diphosphate synthase
2.5.1.69 lavandulyl diphosphate synthase
2.5.1.70 naringenin 8-dimethylallyltransferase
2.5.1.71 leachianone-G 2′′-dimethylallyltransferase
2.5.1.72 quinolinate synthase
2.5.1.73 O-phospho-L-seryl-tRNA:Cys-tRNA synthase
2.5.1.74 1,4-dihydroxy-2-naphthoate polyprenyltransferase
2.5.1.75 tRNA dimethylallyltransferase
2.5.1.76 cysteate synthase
2.5.1.77 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
2.5.1.78 6,7-dimethyl-8-ribityllumazine synthase
2.5.1.79 thermospermine synthase
2.5.1.80 7-dimethylallyltryptophan synthase
2.5.1.81 geranylfarnesyl diphosphate synthase
2.5.1.82 hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
2.5.1.83 hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
2.5.1.84 all-trans-nonaprenyl diphosphate synthase [geranyl-diphosphate specific]
2.5.1.85 all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
2.5.1.86 trans,polycis-decaprenyl diphosphate synthase
2.5.1.87 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]
2.5.1.88 trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]
2.5.1.89 tritrans,polycis-undecaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
2.5.1.90 all-trans-octaprenyl-diphosphate synthase
2.5.1.91 all-trans-decaprenyl-diphosphate synthase
2.5.1.92 (2Z,6Z)-farnesyl diphosphate synthase
2.5.1.93 4-hydroxybenzoate geranyltransferase
2.5.1.94 adenosyl-chloride synthase
2.5.1.95 xanthan ketal pyruvate transferase
2.5.1.96 4,4′-diapophytoene synthase
2.5.1.97 pseudaminic acid synthase
2.5.1.98 Rhizobium leguminosarum exopolysaccharide glucosyl ketal-pyruvate-transferase
2.5.1.99 all-trans-phytoene synthase
2.5.1.100 fumigaclavine A dimethylallyltransferase
2.5.1.101 N,N′-diacetyllegionaminate synthase
2.5.1.102 geranyl-pyrophosphate—olivetolic acid geranyltransferase
2.5.1.103 presqualene diphosphate synthase
2.5.1.104 N1-aminopropylagmatine synthase
2.5.1.105 7,8-dihydropterin-6-yl-methyl-4-(β-D-ribofuranosyl)aminobenzene 5′-phosphate synthase
2.5.1.106 tryprostatin B synthase
2.5.1.107 verruculogen prenyltransferase
2.5.1.108 2-(3-amino-3-carboxypropyl)histidine synthase
2.5.1.109 brevianamide F prenyltransferase (deoxybrevianamide E-forming)
2.5.1.110 12α,13α-dihydroxyfumitremorgin C prenyltransferase
2.5.1.111 4-hydroxyphenylpyruvate 3-dimethylallyltransferase
2.5.1.112 adenylate dimethylallyltransferase (ADP/ATP-dependent)
2.5.1.113 [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase
2.5.1.114 tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase
2.5.1.115 homogentisate phytyltransferase
2.5.1.116 homogentisate geranylgeranyltransferase
2.5.1.117 homogentisate solanesyltransferase
2.5.1.118 β-(isoxazolin-5-on-2-yl)-L-alanine synthase
2.5.1.119 β-(isoxazolin-5-on-4-yl)-L-alanine synthase
2.5.1.120 aminodeoxyfutalosine synthase
2.5.1.121 5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase
2.5.1.122 4-O-dimethylallyl-L-tyrosine synthase
2.5.1.123 flaviolin linalyltransferase
2.5.1.124 6-linalyl-2-O,3-dimethylflaviolin synthase
2.5.1.125 7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase
2.5.1.126 norspermine synthase
2.5.1.127 caldopentamine synthase
2.5.1.128 N4-bis(aminopropyl)spermidine synthase
2.5.1.129 flavin prenyltransferase
2.5.1.130 2-carboxy-1,4-naphthoquinone phytyltransferase
2.5.1.131 (4-{4-[2-(γ-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase
2.5.1.132 3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase
2.5.1.133 bacteriochlorophyll a synthase
2.5.1.134 cystathionine β-synthase (O-acetyl-L-serine)
2.5.1.135 validamine 7-phosphate valienyltransferase
2.5.1.136 2-acylphloroglucinol 4-prenyltransferase
2.5.1.137 2-acyl-4-prenylphloroglucinol 6-prenyltransferase
2.5.1.138 coumarin 8-geranyltransferase
2.5.1.139 umbelliferone 6-dimethylallyltransferase
2.5.1.140 N-(2-amino-2-carboxyethyl)-L-glutamate synthase
2.5.1.141 heme o synthase
2.5.1.142 nerylneryl diphosphate synthase
2.5.1.143 pyridinium-3,5-biscarboxylic acid mononucleotide synthase
2.5.1.144 S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent)
2.5.1.145 phosphatidylglycerol—prolipoprotein diacylglyceryl transferase
2.5.1.146 3-geranyl-3-[(Z)-2-isocyanoethenyl]indole synthase
2.5.1.147 5-amino-6-(D-ribitylamino)uracil—L-tyrosine 4-hydroxyphenyl transferase
2.5.1.148 lycopaoctaene synthase
2.5.1.149 lycopene elongase/hydratase (flavuxanthin-forming)
2.5.1.150 lycopene elongase/hydratase (dihydrobisanhydrobacterioruberin-forming)
2.5.1.151 alkylcobalamin dealkylase
2.5.1.152 D-histidine 2-aminobutanoyltransferase
2.5.1.153 adenosine tuberculosinyltransferase
2.5.1.154 corrinoid adenosyltransferase EutT
2.5.1.155 phosphoglycerol geranylfarnesyltransferase
2.5.1.156 geranylfarnesylglycerol-phosphate geranylfarnesyltransferase
2.6 Transferring nitrogenous groups
2.7 Transferring phosphorus-containing groups
2.8 Transferring sulfur-containing groups
2.9 Transferring selenium-containing groups
2.10 Transferring molybdenum- or tungsten-containing groups
3 Hydrolases
4 Lyases
4.1 Carbon-carbon lyases
4.2 Carbon-oxygen lyases
4.3 Carbon-nitrogen lyases
4.4 Carbon-sulfur lyases
4.5 Carbon-halide lyases
4.6 Phosphorus-oxygen lyases
4.7 carbon-phosphorus lyases
4.8 Nitrogen-oxygen lyases
4.98 ATP-independent chelatases
4.99 Other lyases
5 Isomerases
6 Ligases
7 Translocases