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EC 2.7.8.26 Details
EC number
2.7.8.26
Accepted name
adenosylcobinamide-GDP ribazoletransferase
Reaction
(1) adenosylcobinamide-GDP + α-ribazole = GMP + adenosylcobalamin;;(2) adenosylcobinamide-GDP + α-ribazole 5′-phosphate = GMP + adenosylcobalamin 5′-phosphate
Other name(s)
CobS, cobalamin synthase, cobalamin-5′-phosphate synthase, cobalamin (5′-phosphate) synthase
Systematic name
adenosylcobinamide-GDP:α-ribazole ribazoletransferase
CAS registry number
137672-85-6
Comment
In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, α-ribazole. The second branch of the nucleotide loop assembly pathway is the cobinamide activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by the bifunctional enzyme Cob U. CobS catalyses the final step in adenosylcobalamin biosynthesis, which is the condensation of AdoCbi-GDP with α-ribazole to yield adenosylcobalamin.
History
created 2004
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EC Tree
1 Oxidoreductases
2 Transferases
2.1 Transferring one-carbon groups
2.2 Transferring aldehyde or ketonic groups
2.3 Acyltransferases
2.4 Glycosyltransferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.6 Transferring nitrogenous groups
2.7 Transferring phosphorus-containing groups
2.8 Transferring sulfur-containing groups
2.8.1 Sulfurtransferases
2.8.2 Sulfotransferases
2.8.2.1 aryl sulfotransferase
2.8.2.2 alcohol sulfotransferase
2.8.2.3 amine sulfotransferase
2.8.2.4 estrone sulfotransferase
2.8.2.5 chondroitin 4-sulfotransferase
2.8.2.6 choline sulfotransferase
2.8.2.7 UDP-N-acetylgalactosamine-4-sulfate sulfotransferase
2.8.2.8 [heparan sulfate]-glucosamine N-sulfotransferase
2.8.2.9 tyrosine-ester sulfotransferase
2.8.2.10 Renilla-luciferin sulfotransferase
2.8.2.11 galactosylceramide sulfotransferase
2.8.2.12 created 1972, deleted 2001
2.8.2.13 psychosine sulfotransferase
2.8.2.14 bile-salt sulfotransferase
2.8.2.15 steroid sulfotransferase
2.8.2.16 thiol sulfotransferase
2.8.2.17 chondroitin 6-sulfotransferase
2.8.2.18 cortisol sulfotransferase
2.8.2.19 triglucosylalkylacylglycerol sulfotransferase
2.8.2.20 protein-tyrosine sulfotransferase
2.8.2.21 keratan sulfotransferase
2.8.2.22 aryl-sulfate sulfotransferase
2.8.2.23 [heparan sulfate]-glucosamine 3-sulfotransferase 1
2.8.2.24 aromatic desulfoglucosinolate sulfotransferase
2.8.2.25 flavonol 3-sulfotransferase
2.8.2.26 quercetin-3-sulfate 3′-sulfotransferase
2.8.2.27 quercetin-3-sulfate 4′-sulfotransferase
2.8.2.28 quercetin-3,3′-bissulfate 7-sulfotransferase
2.8.2.29 [heparan sulfate]-glucosamine 3-sulfotransferase 2
2.8.2.30 [heparan sulfate]-glucosamine 3-sulfotransferase 3
2.8.2.31 petromyzonol sulfotransferase
2.8.2.32 scymnol sulfotransferase
2.8.2.33 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
2.8.2.34 glycochenodeoxycholate sulfotransferase
2.8.2.35 dermatan 4-sulfotransferase
2.8.2.36 desulfo-A47934 sulfotransferase
2.8.2.37 trehalose 2-sulfotransferase
2.8.2.38 aliphatic desulfoglucosinolate sulfotransferase
2.8.2.39 hydroxyjasmonate sulfotransferase
2.8.2.40 ω-hydroxy-β-dihydromenaquinone-9 sulfotransferase
2.8.3 CoA-transferases
2.8.3.1 propionate CoA-transferase
2.8.3.2 oxalate CoA-transferase
2.8.3.3 malonate CoA-transferase
2.8.3.4 created 1961, deleted 1964
2.8.3.5 3-oxoacid CoA-transferase
2.8.3.6 3-oxoadipate CoA-transferase
2.8.3.7 succinate—citramalate CoA-transferase
2.8.3.8 acetate CoA-transferase
2.8.3.9 butyrate—acetoacetate CoA-transferase
2.8.3.10 citrate CoA-transferase
2.8.3.11 citramalate CoA-transferase
2.8.3.12 glutaconate CoA-transferase
2.8.3.13 succinate—hydroxymethylglutarate CoA-transferase
2.8.3.14 5-hydroxypentanoate CoA-transferase
2.8.3.15 succinyl-CoA:(R)-benzylsuccinate CoA-transferase
2.8.3.16 formyl-CoA transferase
2.8.3.17 3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase
2.8.3.18 succinyl-CoA:acetate CoA-transferase
2.8.3.19 CoA:oxalate CoA-transferase
2.8.3.20 succinyl-CoA—D-citramalate CoA-transferase
2.8.3.21 L-carnitine CoA-transferase
2.8.3.22 succinyl-CoA—L-malate CoA-transferase
2.8.3.23 caffeate CoA-transferase
2.8.3.24 (R)-2-hydroxy-4-methylpentanoate CoA-transferase
2.8.3.25 bile acid CoA-transferase
2.8.3.26 succinyl-CoA:mesaconate CoA transferase
2.8.3.27 propanoyl-CoA:succinate CoA transferase
2.8.3.28 phenylsuccinyl-CoA transferase
2.8.4 Transferring alkylthio groups
2.8.5 Thiosulfotransferases
2.9 Transferring selenium-containing groups
2.10 Transferring molybdenum- or tungsten-containing groups
3 Hydrolases
4 Lyases
5 Isomerases
6 Ligases
7 Translocases