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EC 1.14.13.225 Details
EC number
1.14.13.225
Accepted name
F-actin monooxygenase
Reaction
[F-actin]-L-methionine + NADPH + O2 + H+ = [F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O
Other name(s)
MICAL (gene name)
Systematic name
[F-actin]-L-methionine,NADPH:O2 S-oxidoreductase
Comment
The enzyme, characterized from the fruit fly Drosophila melanogaster, is a multi-domain oxidoreductase that acts as an F-actin disassembly factor. The enzyme selectively reduces two L-Met residues of F-actin, causing fragmentation of the filaments and preventing repolymerization [1]. Free methionine is not a substrate [2]. The reaction is stereospecific and generates the (R)-sulfoxide [3]. In the absence of substrate, the enzyme can act as an NAD(P)H oxidase (EC 1.6.3.1) [4,5].
History
created 2016
EC Tree
2.8.2.12 created 1972, deleted 2001
2.8.3.4 created 1961, deleted 1964