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EC 1.14.13.218 Details

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EC number

1.14.13.218

Accepted name

5-methylphenazine-1-carboxylate 1-monooxygenase

Reaction

5-methylphenazine-1-carboxylate + NADH + O₂ = pyocyanin + NAD⁺ + CO₂ + H₂O

Other name(s)

phzS (gene name)

Systematic name

5-methylphenazine-1-carboxylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)

Comment

The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is involved in the biosynthesis of pyocyanin, a toxin produced and secreted by the organism. It can also act on phenazine-1-carboxylate, converting it into phenazin-1-ol.

History

created 2016

EC Tree

1 Oxidoreductases

2 Transferases

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.8 Transferring sulfur-containing groups

2.8.1 Sulfurtransferases

2.8.2 Sulfotransferases

2.8.3 CoA-transferases

2.8.3.1 propionate CoA-transferase

2.8.3.2 oxalate CoA-transferase

2.8.3.3 malonate CoA-transferase

2.8.3.4 created 1961, deleted 1964

2.8.3.5 3-oxoacid CoA-transferase

2.8.3.6 3-oxoadipate CoA-transferase

2.8.3.7 succinate—citramalate CoA-transferase

2.8.3.8 acetate CoA-transferase

2.8.3.9 butyrate—acetoacetate CoA-transferase

2.8.3.10 citrate CoA-transferase

2.8.3.11 citramalate CoA-transferase

2.8.3.12 glutaconate CoA-transferase

2.8.3.13 succinate—hydroxymethylglutarate CoA-transferase

2.8.3.14 5-hydroxypentanoate CoA-transferase

2.8.3.15 succinyl-CoA:(R)-benzylsuccinate CoA-transferase

2.8.3.16 formyl-CoA transferase

2.8.3.17 3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase

2.8.3.18 succinyl-CoA:acetate CoA-transferase

2.8.3.19 CoA:oxalate CoA-transferase

2.8.3.20 succinyl-CoA—D-citramalate CoA-transferase

2.8.3.21 L-carnitine CoA-transferase

2.8.3.22 succinyl-CoA—L-malate CoA-transferase

2.8.3.23 caffeate CoA-transferase

2.8.3.24 (R)-2-hydroxy-4-methylpentanoate CoA-transferase

2.8.3.25 bile acid CoA-transferase

2.8.3.26 succinyl-CoA:mesaconate CoA transferase

2.8.3.27 propanoyl-CoA:succinate CoA transferase

2.8.3.28 phenylsuccinyl-CoA transferase

2.8.4 Transferring alkylthio groups

2.8.5 Thiosulfotransferases

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups

2.10.1 Molybdenumtransferases or tungstentransferases with sulfide groups as acceptors