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EC 5.99.1.3 Details

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EC number

5.99.1.3

Accepted name

DNA topoisomerase (ATP-hydrolysing)

Reaction

ATP-dependent breakage, passage and rejoining of double-stranded DNA

Other name(s)

type II DNA topoisomerase, DNA-gyrase, deoxyribonucleate topoisomerase, deoxyribonucleic topoisomerase, topoisomerase, DNA topoisomerase II

Systematic name

DNA topoisomerase (ATP-hydrolysing)

CAS registry number

142805-56-9

Comment

The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC 5.99.1.2 DNA topoisomerase).

History

created 1984, deleted 2018

EC Tree

1 Oxidoreductases

2 Transferases

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups

2.10.1 Molybdenumtransferases or tungstentransferases with sulfide groups as acceptors

2.10.1.1 molybdopterin molybdotransferase

3 Hydrolases

4 Lyases

5 Isomerases

5.1 Racemases and epimerases

5.2 cis-trans-Isomerases

5.3 Intramolecular oxidoreductases

5.4 Intramolecular transferases

5.5 Intramolecular lyases

5.6 Isomerases altering macromolecular conformation

5.99 Other isomerases

5.99.1 Sole sub-subclass for isomerases that do not belong in the other subclasses

5.99.1.1 thiocyanate isomerase

5.99.1.2 DNA topoisomerase

5.99.1.3 DNA topoisomerase (ATP-hydrolysing)

5.99.1.4 2-hydroxychromene-2-carboxylate isomerase

6 Ligases

7 Translocases