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EC 6.3.3.6 Details

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EC number

6.3.3.6

Accepted name

carbapenam-3-carboxylate synthase

Reaction

ATP + (2S,5S)-5-carboxymethylproline = AMP + diphosphate + (3S,5S)-carbapenam 3-carboxylate

Other name(s)

CarA (ambiguous), CPS (ambiguous), carbapenam-3-carboxylate ligase, 6-methyl-(2S,5S)-5-carboxymethylproline cyclo-ligase (AMP-forming)

Systematic name

(2S,5S)-5-carboxymethylproline cyclo-ligase (AMP-forming)

Comment

The enzyme is involved in the biosynthesis of the carbapenem β-lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum.

History

created 2013 as 6.3.1.16, transferred 2013 to EC 6.3.3.6

EC Tree

5.1 Racemases and epimerases

5.2 cis-trans-Isomerases

5.3 Intramolecular oxidoreductases

5.4 Intramolecular transferases

5.5 Intramolecular lyases

5.5.1 Intramolecular lyases (only sub-subclass identified to date)

5.6 Isomerases altering macromolecular conformation

5.99 Other isomerases

5.99.1 Sole sub-subclass for isomerases that do not belong in the other subclasses

6 Ligases

6.1 Forming carbon-oxygen bonds

6.2 Forming carbon-sulfur bonds

6.3 Forming carbon-nitrogen bonds

6.3.1 Acid—ammonia (or amine) ligases (amide synthases)

6.3.2 Acid—amino-acid ligases (peptide synthases)

6.3.3 Cyclo-ligases

6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase

6.3.3.2 5-formyltetrahydrofolate cyclo-ligase

6.3.3.3 dethiobiotin synthase

6.3.3.4 (carboxyethyl)arginine β-lactam-synthase

6.3.3.5 O-ureido-D-serine cyclo-ligase

6.3.3.6 carbapenam-3-carboxylate synthase

6.3.3.7 Ni-sirohydrochlorin a,c-diamide reductive cyclase

6.3.4 Other carbon-nitrogen ligases

6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor

6.4 Forming carbon-carbon bonds

6.5 Forming phosphoric-ester bonds

6.6 Forming nitrogen—metal bonds

6.7 Forming nitrogen-nitrogen bonds

7 Translocases