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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
4 Lyases
5 Isomerases
5.1 Racemases and epimerases
5.2
cis-trans-
Isomerases
5.3 Intramolecular oxidoreductases
5.4 Intramolecular transferases
5.5 Intramolecular lyases
5.5.1 Intramolecular lyases (only sub-subclass identified to date)
5.6 Isomerases altering macromolecular conformation
5.99 Other isomerases
5.99.1 Sole sub-subclass for isomerases that do not belong in the other subclasses
6 Ligases
6.1 Forming carbon-oxygen bonds
6.2 Forming carbon-sulfur bonds
6.2.1 Acid-thiol ligases
6.2.2 Amide---thiol ligases
6.3 Forming carbon-nitrogen bonds
6.3.1 Acidammonia (or amine) ligases (amide synthases)
6.3.2 Acidamino-acid ligases (peptide synthases)
6.3.2.1 pantoate—β-alanine ligase (AMP-forming)
6.3.2.2 glutamate—cysteine ligase
6.3.2.3 glutathione synthase
6.3.2.4
D
-alanine—
D
-alanine ligase
6.3.2.5 phosphopantothenate—cysteine ligase (CTP)
6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase
6.3.2.7 UDP-
N
-acetylmuramoyl-
L
-alanyl-
D
-glutamate—
L
-lysine ligase
6.3.2.8 UDP-
N
-acetylmuramate—
L
-alanine ligase
6.3.2.9 UDP-
N
-acetylmuramoyl-
L
-alanine—
D
-glutamate ligase
6.3.2.10 UDP-
N
-acetylmuramoyl-tripeptide—
D
-alanyl-
D
-alanine ligase
6.3.2.11 carnosine synthase
6.3.2.12 dihydrofolate synthase
6.3.2.13 UDP-
N
-acetylmuramoyl-
L
-alanyl-
D
-glutamate—2,6-diaminopimelate ligase
6.3.2.14 enterobactin synthase
6.3.2.15 created 1976, deleted 2002
6.3.2.16
D
-alanine—alanyl-poly(glycerolphosphate) ligase
6.3.2.17 tetrahydrofolate synthase
6.3.2.18 γ-glutamylhistamine synthase
6.3.2.19 ubiquitin—protein ligase
6.3.2.20 indoleacetate—lysine synthetase
6.3.2.21 ubiquitin—calmodulin ligase
6.3.2.22 diphthine—ammonia ligase
6.3.2.23 homoglutathione synthase
6.3.2.24 tyrosine—arginine ligase
6.3.2.25 tubulin—tyrosine ligase
6.3.2.26
N
-(5-amino-5-carboxypentanoyl)-
L
-cysteinyl-
D
-valine synthase
6.3.2.27 aerobactin synthase
6.3.2.28
L
-amino-acid α-ligase
6.3.2.29 cyanophycin synthase (
L
-aspartate-adding)
6.3.2.30 cyanophycin synthase (
L
-arginine-adding)
6.3.2.31 coenzyme F
420
-0:
L
-glutamate ligase
6.3.2.32 coenzyme γ-F
420
-2:α-
L
-glutamate ligase
6.3.2.33 tetrahydrosarcinapterin synthase
6.3.2.34 coenzyme F
420
-1:γ-
L
-glutamate ligase
6.3.2.35
D
-alanine—
D
-serine ligase
6.3.2.36 4-phosphopantoate—β-alanine ligase
6.3.2.37 UDP-
N
-acetylmuramoyl-
L
-alanyl-
D
-glutamate—
D
-lysine ligase
6.3.2.38
N
2
-citryl-
N
6
-acetyl-
N
6
-hydroxylysine synthase
6.3.2.39 aerobactin synthase
6.3.2.40 cyclopeptine synthase
6.3.2.41
N
-acetylaspartylglutamate synthase
6.3.2.42
N
-acetylaspartylglutamylglutamate synthase
6.3.2.43 [amino-group carrier protein]—
L
-2-aminoadipate ligase
6.3.2.44 pantoate—β-alanine ligase (ADP-forming)
6.3.2.45 UDP-
N
-acetylmuramate—
L
-alanyl-γ-
D
-glutamyl-
meso
-2,6-diaminoheptanedioate ligase
6.3.2.46 fumarate—(
S
)-2,3-diaminopropanoate ligase
6.3.2.47 dapdiamide synthase
6.3.2.48
L
-arginine-specific
L
-amino acid ligase
6.3.2.49
L
-alanine—
L
-anticapsin ligase
6.3.2.50 tenuazonic acid synthetase
6.3.2.51 phosphopantothenate—cysteine ligase (ATP)
6.3.2.52 jasmonoyl—
L
-amino acid ligase
6.3.2.53 UDP-
N
-acetylmuramoyl-
L
-alanine—
L
-glutamate ligase
6.3.2.54
L
-2,3-diaminopropanoate—citrate ligase
6.3.2.55 2-[(
L
-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase
6.3.2.56 staphyloferrin B synthase
6.3.2.57 staphyloferrin A synthase
6.3.2.58
D
-ornithine—citrate ligase
6.3.2.59 3-methyl-
D
-ornithine—
L
-lysine ligase
6.3.2.60 glutamate—[amino group carrier protein] ligase
6.3.2.61 tubulin-glutamate ligase
6.3.2.62 β-tubulin-glutamate ligase
6.3.3 Cyclo-ligases
6.3.4 Other carbon-nitrogen ligases
6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
6.4 Forming carbon-carbon bonds
6.5 Forming phosphoric-ester bonds
6.6 Forming nitrogenmetal bonds
6.7 Forming nitrogen-nitrogen bonds
7 Translocases