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EC 1.14.14.18 Details
show Brenda entryEC number
1.14.14.18
Accepted name
heme oxygenase (biliverdin-producing)
Reaction
protoheme + 3 [reduced NADPH—hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH—hemoprotein reductase] + 3 H2O
Other name(s)
ORP33 proteins,
haem oxygenase (ambiguous),
heme oxygenase (decyclizing) (ambiguous),
heme oxidase (ambiguous),
haem oxidase (ambiguous),
heme oxygenase (ambiguous),
heme,hydrogen-donor:oxygen oxidoreductase (α-methene-oxidizing, hydroxylating)
Systematic name
protoheme,NADPH—hemoprotein reductase:oxygen oxidoreductase (α-methene-oxidizing, hydroxylating)
CAS registry number
9059-22-7
Comment
This mammalian enzyme participates in the degradation of heme. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules [4]. The third oxygen molecule provides the oxygen atom that converts the α-carbon to CO. The enzyme requires NAD(P)H and EC 1.6.2.4, NADPH—hemoprotein reductase. cf. EC 1.14.15.20, heme oxygenase (biliverdin-producing, ferredoxin).
History
created 1972 as EC 1.14.99.3, modified 2006, transferred 2015 to EC 1.14.14.18, modified 2016
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
