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EC 2.1.1.63 Details
EC number
2.1.1.63
Accepted name
methylated-DNA—[protein]-cysteine S-methyltransferase
Reaction
(1) DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine;;(2) DNA (containing 4-O-methylthymine) + protein L-cysteine = DNA (without 4-O-methylthymine) + protein S-methyl-L-cysteine
Other name(s)
ada (gene name), ogt (gene name), MGT1 (gene name), MGMT (gene name)
Systematic name
DNA-6-O-methylguanine/DNA-4-O-methylthymine:[protein]-L-cysteine S-methyltransferase
CAS registry number
77271-19-3
Comment
This protein is involved in the repair of methylated DNA. Unlike EC 3.2.2.20, DNA-3-methyladenine glycosidase I and EC 3.2.2.21, DNA-3-methyladenine glycosidase II, which remove the methylated base leaving an apurinic/apyrimidinic site, this enzyme transfers the methyl group from the methylated DNA to an internal cysteine residue, leaving an intact nucleotide. Since the methyl transfer is irreversible, the enzyme can only catalyse a single turnover.
History
created 1982, modified 1983, modified 1999, modified 2003, modified 2017
EC Tree
2.1.1.23 created 1972, modified 1976, modified 1983, deleted 1999
2.1.1.24 created 1972, modified 1983, modified 1989, deleted 1992
2.1.1.30 created 1972, deleted 1981
2.1.1.58 created 1981, deleted 1984
2.1.1.73 created 1984, deleted 2003
2.1.1.81 created 1989, deleted 1990
2.1.1.134 created 1999, deleted 2002
2.1.1.135 created 1999, deleted 2003
2.1.1.138 created 2000, deleted 2003