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EC 2.1.2.10 Details

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EC number

2.1.2.10

Accepted name

aminomethyltransferase

Reaction

[protein]-S⁸-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH₃

Other name(s)

S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming), T-protein, glycine synthase, tetrahydrofolate aminomethyltransferase, [protein]-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming)

Systematic name

[protein]-S⁸-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming)

CAS registry number

37257-08-2

Comment

A component, with EC 1.4.4.2 glycine dehydrogenase (decarboxylating) and EC 1.8.1.4, dihydrolipoyl dehydrogenanse, of the glycine cleavage system, formerly known as glycine synthase. The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein [3].

History

created 1972, modified 2003, modified 2006

EC Tree

1 Oxidoreductases

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.2 Hydroxymethyl-, formyl- and related transferases

2.1.2.1 glycine hydroxymethyltransferase

2.1.2.2 phosphoribosylglycinamide formyltransferase 1

2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase

2.1.2.4 glycine formimidoyltransferase

2.1.2.5 glutamate formimidoyltransferase

2.1.2.6 created 1965, deleted 1984

2.1.2.7 D-alanine 2-hydroxymethyltransferase

2.1.2.8 deoxycytidylate 5-hydroxymethyltransferase

2.1.2.9 methionyl-tRNA formyltransferase

2.1.2.10 aminomethyltransferase

2.1.2.11 3-methyl-2-oxobutanoate hydroxymethyltransferase

2.1.2.12 created 1983, deleted 1984

2.1.2.13 UDP-4-amino-4-deoxy-L-arabinose formyltransferase

2.1.2.14 GDP-perosamine N-formyltransferase

2.1.3 Carboxy- and carbamoyltransferases

2.1.4 Amidinotransferases

2.1.5 Methylenetransferases

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups