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EC number
Accepted name
protein-Nπ-phosphohistidine—D-mannose phosphotransferase
[protein]-Nπ-phospho-L-histidine + D-mannose[side 1] = [protein]-L-histidine + D-mannose 6-phosphate[side 2]
Other name(s)
manXYZ (gene names), mannose PTS permease, EIIMan, Enzyme IIMan
Systematic name
protein-Nπ-phospho-L-histidine:D-mannose Nπ-phosphotransferase
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC (phosphoenolpyruvate—protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
created 1972 as EC, part transferred 2016 to EC
EC Browser created 1961, deleted 1965 created 1972, deleted 1984 created 1972, deleted 2004 created 1972, deleted 1976 created 1978, deleted 1978 created 1978, deleted 1992 created 1978, deleted 1984 created 1984, deleted 1992 created 1990, deleted 2002 created 1992, deleted 2002 created 2002, deleted 2003