EC Explorer

[browse EC tree] - [search]

EC 2.7.4.22 Details

show Brenda entry

EC number

2.7.4.22

Accepted name

UMP kinase

Reaction

ATP + UMP = ADP + UDP

Other name(s)

uridylate kinase, UMPK, uridine monophosphate kinase, PyrH, UMP-kinase, SmbA

Systematic name

ATP:UMP phosphotransferase

CAS registry number

9036-23-1

Comment

This enzyme is strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme UMP/CMP kinase (EC 2.7.4.14) for the same purpose [2]. This enzyme is the subject of feedback regulation, being inhibited by UTP and activated by GTP [1].

History

created 2006

EC Tree

1 Oxidoreductases

2 Transferases

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.2 Phosphotransferases with a carboxy group as acceptor

2.7.3 Phosphotransferases with a nitrogenous group as acceptor

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.4.1 ATP-polyphosphate phosphotransferase

2.7.4.2 phosphomevalonate kinase

2.7.4.3 adenylate kinase

2.7.4.4 nucleoside-phosphate kinase

2.7.4.5 created 1961, deleted 1972

2.7.4.6 nucleoside-diphosphate kinase

2.7.4.7 phosphooxymethylpyrimidine kinase

2.7.4.8 guanylate kinase

2.7.4.9 dTMP kinase

2.7.4.10 nucleoside-triphosphate—adenylate kinase

2.7.4.11 (deoxy)adenylate kinase

2.7.4.12 T₂-induced deoxynucleotide kinase

2.7.4.13 (deoxy)nucleoside-phosphate kinase

2.7.4.14 UMP/CMP kinase

2.7.4.15 thiamine-diphosphate kinase

2.7.4.16 thiamine-phosphate kinase

2.7.4.17 3-phosphoglyceroyl-phosphate—polyphosphate phosphotransferase

2.7.4.18 farnesyl-diphosphate kinase

2.7.4.19 5-methyldeoxycytidine-5′-phosphate kinase

2.7.4.20 dolichyl-diphosphate—polyphosphate phosphotransferase

2.7.4.21 inositol-hexakisphosphate 5-kinase

2.7.4.22 UMP kinase

2.7.4.23 ribose 1,5-bisphosphate phosphokinase

2.7.4.24 diphosphoinositol-pentakisphosphate 1-kinase

2.7.4.25 (d)CMP kinase

2.7.4.26 isopentenyl phosphate kinase

2.7.4.27 [pyruvate, phosphate dikinase]-phosphate phosphotransferase

2.7.4.28 [pyruvate, water dikinase]-phosphate phosphotransferase

2.7.4.29 Kdo₂-lipid A phosphotransferase

2.7.4.30 lipid A phosphoethanolamine transferase

2.7.4.31 [5-(aminomethyl)furan-3-yl]methyl phosphate kinase

2.7.4.32 farnesyl phosphate kinase

2.7.4.33 AMP-polyphosphate phosphotransferase

2.7.4.34 GDP-polyphosphate phosphotransferase

2.7.5 Phosphotransferases with regeneration of donors, apparently catalysing intramolecular transfers (deleted sub-subclass)

2.7.6 Diphosphotransferases

2.7.7 Nucleotidyltransferases

2.7.8 Transferases for other substituted phosphate groups

2.7.9 Phosphotransferases with paired acceptors

2.7.10 Protein-tyrosine kinases

2.7.11 Protein-serine/threonine kinases

2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)

2.7.13 Protein-histidine kinases

2.7.14 Protein-arginine kinases

2.7.99 Other protein kinases

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups