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EC 2.7.7.6 Details
EC number
2.7.7.6
Accepted name
DNA-directed RNA polymerase
Reaction
nucleoside triphosphate + RNAn = diphosphate + RNAn+1
Other name(s)
RNA polymerase, RNA nucleotidyltransferase (DNA-directed), RNA polymerase I, RNA polymerase II, RNA polymerase III, C RNA formation factors, deoxyribonucleic acid-dependent ribonucleic acid polymerase, DNA-dependent ribonucleate nucleotidyltransferase, DNA-dependent RNA nucleotidyltransferase, DNA-dependent RNA polymerase, ribonucleate nucleotidyltransferase, ribonucleate polymerase, C ribonucleic acid formation factors, ribonucleic acid nucleotidyltransferase, ribonucleic acid polymerase, ribonucleic acid transcriptase, ribonucleic polymerase, ribonucleic transcriptase, RNA nucleotidyltransferase, RNA transcriptase, transcriptase, RNA nucleotidyltransferase I
Systematic name
nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
CAS registry number
9014-24-8
Comment
Catalyses DNA-template-directed extension of the 3′- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to α-amanitin, and the type of RNA synthesized. See also EC 2.7.7.19 (polynucleotide adenylyltransferase) and EC 2.7.7.48 (RNA-directed RNA polymerase).
History
created 1961, modified 1981, modified 1982, modified 1989
EC Tree
2.7.7.16 created 1961, deleted 1972, [transferred to EC 3.1.4.22, deleted 1980]
2.7.7.17 created 1965, deleted 1972, [transferred to EC 3.1.4.23, deleted 1980]
2.7.7.20 created 1965, deleted 1972
2.7.7.26 created 1961 as EC 3.1.4.8, transferred 1965 to EC 2.7.7.26, deleted 1972
2.7.7.29 created 1972, deleted 2004