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EC 2.8.3.8 Details
EC number
2.8.3.8
Accepted name
acetate CoA-transferase
Reaction
acyl-CoA + acetate = a fatty acid anion + acetyl-CoA
Other name(s)
acetate coenzyme A-transferase, butyryl CoA:acetate CoA transferase, butyryl coenzyme A transferase
Systematic name
acyl-CoA:acetate CoA-transferase
CAS registry number
37278-35-6
Comment
The enzyme belongs to family I of CoA-transferases, which operate with a ping-pong kinetic mechanism. The reaction takes place in two half-reactions and involves the formation of a CoA thioester intermediate with a glutamate residue. Unlike EC 2.8.3.9, butyrate—acetoacetate CoA-transferase, this enzyme exhibits maximal activity using acetate as the CoA acceptor. Substrate range depends on the specific enzyme. Typical substrates include butanoyl-CoA and pentanoyl-CoA.
History
created 1972
EC Tree
2.8.3.4 created 1961, deleted 1964