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EC 3.1.21.3 Details
show Brenda entryEC number
3.1.21.3
Accepted name
type I site-specific deoxyribonuclease
Reaction
Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5′-phosphates; ATP is simultaneously hydrolysed
Other name(s)
type I restriction enzyme,
deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent),
restriction-modification system,
deoxyribonuclease (adenosine triphosphate-hydrolyzing),
adenosine triphosphate-dependent deoxyribonuclease,
ATP-dependent DNase,
type 1 site-specific deoxyribonuclease
CAS registry number
37263-09-5
Comment
This is a large group of enzymes which, together with those now listed as EC 3.1.21.4 (type II site-specific deoxyribonuclease) and EC 3.1.21.5 (type III site-specific deoxyribonuclease), were previously listed separately in sub-subclasses EC 3.1.23 and EC 3.1.24. They have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. They recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. They are multifunctional proteins that also catalyse the reactions of EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] and EC 2.1.1.37
History
created 1984 from EC 3.1.23 and EC 3.1.24
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1 Oxidoreductases
3 Hydrolases
3.1.21.1 deoxyribonuclease I
