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EC 3.1.4.53 Details
EC number
3.1.4.53
Accepted name
3′,5′-cyclic-AMP phosphodiesterase
Reaction
adenosine 3′,5′-cyclic phosphate + H2O = AMP
Other name(s)
cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2
Systematic name
3′,5′-cyclic-AMP 5′-nucleotidohydrolase
Comment
Requires Mg2+ or Mn2+ for activity [2]. This enzyme is specific for 3′,5′-cAMP and does not hydrolyse other nucleoside 3′,5′-cyclic phosphates such as cGMP (cf. EC 3.1.4.17, 3,5-cyclic-nucleotide phosphodiesterase and EC 3.1.4.35, 3,5-cyclic-GMP phosphodiesterase). It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation [3].
History
created 2008, modified 2011
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EC Tree
1 Oxidoreductases
2 Transferases
3 Hydrolases
3.1 Acting on ester bonds
3.1.1 Carboxylic-ester hydrolases
3.1.2 Thioester hydrolases
3.1.3 Phosphoric-monoester hydrolases
3.1.4 Phosphoric-diester hydrolases
3.1.4.1 phosphodiesterase I
3.1.4.2 glycerophosphocholine phosphodiesterase
3.1.4.3 phospholipase C
3.1.4.4 phospholipase D
3.1.4.5 created 1961, deleted 1978
3.1.4.6 created 1961, deleted 1978
3.1.4.7 created 1961, deleted 1978
3.1.4.8 created 1961, transferred 1965 to EC 2.7.7.26, reinstated 1972, deleted 1978
3.1.4.9 created 1965, deleted 1978
3.1.4.10 created 1972, modified 1976, deleted 2002
3.1.4.11 phosphoinositide phospholipase C
3.1.4.12 sphingomyelin phosphodiesterase
3.1.4.13 serine-ethanolaminephosphate phosphodiesterase
3.1.4.14 [acyl-carrier-protein] phosphodiesterase
3.1.4.15 adenylyl-[glutamate—ammonia ligase] hydrolase
3.1.4.16 2′,3′-cyclic-nucleotide 2′-phosphodiesterase
3.1.4.17 3′,5′-cyclic-nucleotide phosphodiesterase
3.1.4.18 created 1972, deleted 1978
3.1.4.19 created 1972, deleted 1978
3.1.4.20 created 1972, deleted 1978
3.1.4.21 created 1972, deleted 1978
3.1.4.22 created 1972, deleted 1978
3.1.4.23 created 1972, deleted 1978
3.1.4.24 created 1972, deleted 1978
3.1.4.25 created 1972, deleted 1978
3.1.4.26 created 1972, deleted 1978
3.1.4.27 created 1972, deleted 1978
3.1.4.28 created 1972, deleted 1978
3.1.4.29 created 1972, deleted 1978
3.1.4.30 created 1972, deleted 1978
3.1.4.31 created 1972, deleted 1978
3.1.4.32 created 1972, deleted 1978
3.1.4.33 created 1972, deleted 1978
3.1.4.34 created 1972, deleted 1978
3.1.4.35 3′,5′-cyclic-GMP phosphodiesterase
3.1.4.36 created 1976, deleted 2002
3.1.4.37 2′,3′-cyclic-nucleotide 3′-phosphodiesterase
3.1.4.38 glycerophosphocholine cholinephosphodiesterase
3.1.4.39 alkylglycerophosphoethanolamine phosphodiesterase
3.1.4.40 CMP-N-acylneuraminate phosphodiesterase
3.1.4.41 sphingomyelin phosphodiesterase D
3.1.4.42 glycerol-1,2-cyclic-phosphate 2-phosphodiesterase
3.1.4.43 glycerophosphoinositol inositolphosphodiesterase
3.1.4.44 glycerophosphoinositol glycerophosphodiesterase
3.1.4.45 N-acetylglucosamine-1-phosphodiester α-N-acetylglucosaminidase
3.1.4.46 glycerophosphodiester phosphodiesterase
3.1.4.47 created 1989, deleted 2002
3.1.4.48 dolichylphosphate-glucose phosphodiesterase
3.1.4.49 dolichylphosphate-mannose phosphodiesterase
3.1.4.50 glycosylphosphatidylinositol phospholipase D
3.1.4.51 glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase
3.1.4.52 cyclic-guanylate-specific phosphodiesterase
3.1.4.53 3′,5′-cyclic-AMP phosphodiesterase
3.1.4.54 N-acetylphosphatidylethanolamine-hydrolysing phospholipase D
3.1.4.55 phosphoribosyl 1,2-cyclic phosphate phosphodiesterase
3.1.4.56 7,8-dihydroneopterin 2′,3′-cyclic phosphate phosphodiesterase
3.1.4.57 phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase
3.1.4.58 RNA 2′,3′-cyclic 3′-phosphodiesterase
3.1.4.59 cyclic-di-AMP phosphodiesterase
3.1.4.60 pApA phosphodiesterase
3.1.4.61 cyclic 2,3-diphosphoglycerate hydrolase
3.1.5 Triphosphoric-monoester hydrolases
3.1.6 Sulfuric-ester hydrolases
3.1.7 Diphosphoric-monoester hydrolases
3.1.8 Phosphoric-triester hydrolases
3.1.11 Exodeoxyribonucleases producing 5′-phosphomonoesters
3.1.12 Exodeoxyribonucleases producing 3′-phosphomonoesters
3.1.13 Exoribonucleases producing 5′-phosphomonoesters
3.1.14 Exoribonucleases producing 3'-phosphomonoesters
3.1.15 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters
3.1.16 Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters
3.1.22 Endodeoxyribonucleases producing 3'-phosphomonoesters
3.1.23 Site-specific endodeoxyribonucleases: cleavage is sequence specific (deleted sub-subclass)
3.1.24 Site specific endodeoxyribonucleases: cleavage is not sequence specific (deleted sub-subclass)
3.1.25 Site-specific endodeoxyribonucleases that are specific for altered bases
3.1.26 Endoribonucleases producing 5'-phosphomonoesters
3.1.27 Endoribonucleases producing 3'-phosphomonoesters
3.1.30 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters
3.1.31 Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
3.2 Glycosylases
3.3 Acting on ether bonds
3.4 Acting on peptide bonds (peptidases)
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.6 Acting on acid anhydrides
3.7 Acting on carbon-carbon bonds
3.8 Acting on halide bonds
3.9 Acting on phosphorus-nitrogen bonds
3.10 Acting on sulfur-nitrogen bonds
3.11 Acting on carbon-phosphorus bonds
3.12 Acting on sulfur-sulfur bonds
3.13 Acting on carbon-sulfur bonds
4 Lyases
5 Isomerases
6 Ligases
7 Translocases