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EC 5.5.1.1 Details

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EC number

5.5.1.1

Accepted name

muconate cycloisomerase

Reaction

(+)-muconolactone = cis,cis-muconate

Other name(s)

muconate cycloisomerase I, cis,cis-muconate-lactonizing enzyme, cis,cis-muconate cycloisomerase, muconate lactonizing enzyme, 4-carboxymethyl-4-hydroxyisocrotonolactone lyase (decyclizing), CatB, MCI, 2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing), 2,5-dihydro-5-oxofuran-2-acetate lyase (ring-opening)

Systematic name

(+)-muconolactone lyase (ring-opening)

CAS registry number

9023-72-7

Comment

Requires Mn²⁺. Also acts (in the reverse reaction) on 3-methyl-cis,cis-muconate and, very slowly, on cis,trans-muconate. Not identical with EC 5.5.1.7 (chloromuconate cycloisomerase) or EC 5.5.1.11 (dichloromuconate cycloisomerase).

History

created 1961

EC Tree

5.1 Racemases and epimerases

5.2 cis-trans-Isomerases

5.3 Intramolecular oxidoreductases

5.4 Intramolecular transferases

5.5 Intramolecular lyases

5.5.1 Intramolecular lyases (only sub-subclass identified to date)

5.5.1.1 muconate cycloisomerase

5.5.1.2 3-carboxy-cis,cis-muconate cycloisomerase

5.5.1.3 tetrahydroxypteridine cycloisomerase

5.5.1.4 inositol-3-phosphate synthase

5.5.1.5 carboxy-cis,cis-muconate cyclase

5.5.1.6 chalcone isomerase

5.5.1.7 chloromuconate cycloisomerase

5.5.1.8 (+)-bornyl diphosphate synthase

5.5.1.9 cycloeucalenol cycloisomerase

5.5.1.10 α-pinene-oxide decyclase

5.5.1.11 dichloromuconate cycloisomerase

5.5.1.12 copalyl diphosphate synthase

5.5.1.13 ent-copalyl diphosphate synthase

5.5.1.14 syn-copalyl-diphosphate synthase

5.5.1.15 terpentedienyl-diphosphate synthase

5.5.1.16 halimadienyl-diphosphate synthase

5.5.1.17 (S)-β-macrocarpene synthase

5.5.1.18 lycopene ε-cyclase

5.5.1.19 lycopene β-cyclase

5.5.1.20 prosolanapyrone-III cycloisomerase

5.5.1.21 copal-8-ol diphosphate synthase

5.5.1.22 (–)-bornyl diphosphate synthase

5.5.1.23 aklanonic acid methyl ester cyclase

5.5.1.24 tocopherol cyclase

5.5.1.25 3,6-anhydro-L-galactonate cycloisomerase

5.5.1.26 nogalonic acid methyl ester cyclase

5.5.1.27 D-galactarolactone cycloisomerase

5.5.1.28 (–)-kolavenyl diphosphate synthase

5.5.1.29 (+)-kolavenyl diphosphate synthase

5.5.1.30 labda-7,13-dienyl diphosphate synthase

5.5.1.31 hapalindole H synthase

5.5.1.32 12-epi-hapalindole U synthase

5.5.1.33 12-epi-fischerindole U synthase

5.5.1.34 (+)-cis,trans-nepetalactol synthase

5.5.1.35 (+)-cis,cis-nepetalactol synthase

5.6 Isomerases altering macromolecular conformation

5.99 Other isomerases

6 Ligases

7 Translocases